The Science behind the Tip
The identification of an individual´s genetic risk of a disease is increasingly recognized as
a tool in disease risk prediction. In glaucoma terms, patients with high genetic risk are
those individuals with the presence of a high polygenic risk score which has been shown
to confer a risk of developing glaucoma similar for carriers of common genes associated
with primary open angle glaucoma such as MYOC gene.
High polygenic risk individuals have a greater likelihood of glaucoma progression (rapid
visual field worsening and a higher rate of retinal nerve fiber layer thinning) compared
with low-genetic risk individuals (2,3).
Incorporating these findings in clinical practice is currently challenging but will allow
glaucoma specialists to identify individuals who are more susceptible to progression and
who may benefit from earlier or more intensive treatments, lower target IOP and more
frequent monitoring (3).
Tip of the Month manager: Frances Meier-Gibbons
Tip of the Month editorial board: Francisco Goni, Karl Mercieca, Humma Shahid
Tip of the Month editors in chief: Manuele Michelessi, Francesco Oddone