TRPV4 and Glaucoma

The TRPV4 ion channel plays a role in several retinal functions. TRPV4 may participate in the response to mechanical and osmotic stimuli within the retina, as has been suggested in other ocular tissues implicated in glaucoma. At the cellular level, this channel is present in Müller cells, where it activates processes involved in RGC death. It also functions in trabecular meshwork cells, inducing pore formation in the Schlemm’s canal. The involvement of this channel in glaucoma is noteworthy, as it could represent a future therapeutic target. Our research group (www.ehu.eus/gobe) has discovered that the response of this receptor differs between central and peripheral Müller cells, and that it plays a role in the neuroprotection of RGCs in glaucoma.

Histological section of a glaucomatous retina immunostained for the pressure-sensitive receptor TRPV4. Lower expression is observed in the central retina compared to the periphery, suggesting higher pressure sensitivity in peripheral regions. These differences indicate that future therapies could target region-specific modulation of pressure sensitivity to prevent retinal damage.

References

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC10770903/pdf/13578_2023_Article_1186.pdf

Contributor: Elena Vecino
EduP Manager: Aritz Urcola