What have we learned about exfoliation syndrome since its discovery by John Lindberg 100 years ago?

Author(s): Nazarali S (1), Damji F (2), Damji KF (3)

1 Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
2 School of Kinesiology, Faculty of Education, University of British Columbia, Vancouver, British Columbia, Canada.
3 Department of Ophthalmology and Visual Sciences, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Exfoliation syndrome (XFS) is a systemic disease with significant ocular manifestations, including glaucoma and cataract. The disease impacts close to 70 million people globally and is now recognised as the most common identifiable cause of open-angle glaucoma. Since the discovery of XFS 100 years ago by Dr John G. Lindberg, there has been considerable advancement in understanding its pathogenesis and resulting clinical implications.

The purpose of this paper is to summarise information regarding the epidemiology, pathophysiology, ocular manifestations and systemic associations of XFS with the objective of sharing clinical pearls to assist in early detection and enhanced management of patients.

Br J Ophthalmol. 2018 Mar 22. pii: bjophthalmol-2017-311321. doi: 10.1136/bjophthalmol-2017-311321.

http://www.ncbi.nlm.nih.gov/pubmed/29567789

Keywords: Exfoliation Syndrome; Exfoliative Glaucoma; Glaucoma

Clinical Paper of the Month manager: Andreas Boehm