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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

    Learn more...
  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

    Learn more...
    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

    Learn more...
  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

    Learn more...
  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

    Learn more...
    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

    Learn more...
  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Experimental Paper of the Month

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Author(s): Xikun Han 1,2,37 , Puya Gharahkhani 1,2,3,37, Andrew R. Hamel 4,5, Jue Sheng Ong 1, Miguel E. Rentería 2,3,6, Puja Mehta 4,5, Xianjun...

October 15, 2023

MERCURY‑3: a randomized comparison of netarsudil/latanoprost and bimatoprost/timolol in open‑angle glaucoma and ocular hypertension

Clinical paper of the month

MERCURY‑3: a randomized comparison of netarsudil/latanoprost and bimatoprost/timolol in open‑angle glaucoma and ocular hypertension

Author(s): Ingeborg Stalmans1,2 · Kin Sheng Lim3 · Francesco Oddone4 · Marek Fichtl5,6 · Jose I. Belda7,8 · Anton Hommer9 · Guna Laganovska10 ·...

October 15, 2023

Consider sources of bias when using OCT angiography

Tip of the month

Consider sources of bias when using OCT angiography

The Science behind the Tip OCT angiography (OCTA) has gained great interest in glaucoma diagnosis (1, 2) and follow up(3). However, several...

October 15, 2023

Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer

Experimental Paper of the Month

Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer

Author(s): Ronen E Mukamel (1), Robert E Handsaker (2), Maxwell A Sherman (3), Alison R Barton (4), Margaux L A Hujoel (5), Steven A McCarroll (6),...

September 15, 2023

Long-term Impact of Immediate Versus Delayed Treatment of Early Glaucoma: Results From the Early Manifest Glaucoma Trial

NGP Paper

Long-term Impact of Immediate Versus Delayed Treatment of Early Glaucoma: Results From the Early Manifest Glaucoma Trial

PURPOSE: To compare long-term visual outcomes in the 2 arms of the Early Manifest Glaucoma Trial (EMGT) and determine if delayed treatment was...

September 15, 2023

OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing

Tip of the month

OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing

The Science behind the Tip Thanks to its high reproducibility,1-3 OCT has become widely used for monitoring structural optic nerve changes in...

September 15, 2023

Intravitreal bevacizumab improves trabeculectomy survival at 12 months: the bevacizumab in trabeculectomy study-a randomised clinical trial

Clinical paper of the month

Intravitreal bevacizumab improves trabeculectomy survival at 12 months: the bevacizumab in trabeculectomy study-a randomised clinical trial

Author(s): John A Landers, Sean Mullany, Jamie E Craig 1 Ophthalmology, Flinders University of South Australia, Adelaide, South Australia,...

September 15, 2023

Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema

Tip of the month

Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema

The Science behind the Tip Patients undergoing anti-VEGF (vascular endothelial growth factor) therapy for age-related macular degeneration or...

August 31, 2023

Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

Tip of the month

Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

July 30, 2023

Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

Clinical paper of the month

Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

July 30, 2023

Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Experimental Paper of the Month

Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

July 30, 2023

Angle Closure SIG

SIG Corner

Angle Closure SIG

SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

July 30, 2023

Ligand-induced activation and G protein coupling of prostaglandin F2α receptor

Experimental Paper of the Month

Ligand-induced activation and G protein coupling of prostaglandin F2α receptor

Author(s): Canrong Wu (1), Youwei Xu (2), Qian He (2), Dianrong Li (3), Jia Duan (2), Changyao Li (4,5), Chongzhao You (2), Han Chen (6), Weiliang...

June 30, 2023

Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss

Clinical paper of the month

Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss

Author(s): Aidan B Jackson (1), Keith R Martin (2), Michael A Coote (1), Felipe A Medeiros (3), Christopher A Girkin (4), Massimo A Fazio (4),...

June 30, 2023

Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

NGP Paper

Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

June 30, 2023

When interpreting RNFL OCT scans, attention should be paid to the presence of peripapillary retinoschisis

Tip of the month

When interpreting RNFL OCT scans, attention should be paid to the presence of peripapillary retinoschisis

Peripapillary retinoschisis (PPRS) occurs significantly more frequently in glaucoma patients (1%-6%) compared to healthy subjects (0.5%) (1). The...

June 30, 2023

Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia

Experimental Paper of the Month

Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia

Author(s): Mahmoud T KhalafAllah (1,2), Preston A Fuchs (3), Fred Nugen (3), Mustapha El Hamdaoui (3), Alexander Levy (4), David T Redden (5),...

May 31, 2023

Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression

Clinical paper of the month

Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression

Author(s): Felipe A Medeiros (1), Alessandro A Jammal (2) 1 Vision, Imaging and Performance Laboratory, Duke Eye Center, Duke University, Durham,...

May 31, 2023

OCT can be a helpful additional tool to differentiate glaucoma from other optic neuropathi

Tip of the month

OCT can be a helpful additional tool to differentiate glaucoma from other optic neuropathi

Differentiating between glaucomatous and non-glaucomatous optic neuropathies can be quite challenging. In addition to a thorough clinical history...

May 31, 2023

MIND diet lowers risk of open-angle glaucoma: the Rotterdam Study

Clinical paper of the month

MIND diet lowers risk of open-angle glaucoma: the Rotterdam Study

Author(s): Joëlle E Vergroesen (1,2), Tosca O E de Crom (2), Cornelia M van Duijn (3), Trudy Voortman (2,4), Caroline C W Klaver (1,2,5,6), Wishal...

April 30, 2023

Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

Tip of the month

Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

April 21, 2023

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma

Experimental Paper of the Month

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma

Author(s): Jae H Kang (1), Oana Zeleznik (1), Lisa Frueh (1), Jessica Lasky-Su (1), A Heather Eliassen (1,2), Clary Clish (3), Bernard A Rosner...

April 01, 2023

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

Experimental Paper of the Month

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

Author(s): W Daniel Stamer (1), Kristin M Perkumas (1), Min H Kang (2), Mohammed Dibas (3), Michael R Robinson (3), Douglas J Rhee (2) 1 Department...

March 31, 2023

Use corneal hysteresis to identify high-risk glaucoma patients

Tip of the month

Use corneal hysteresis to identify high-risk glaucoma patients

Identifying those patients at greater risk of disease progression is a key step in glaucoma management algorithms. Several variables have been...

March 31, 2023

The relationship between multiple deprivation and severity of glaucoma at diagnosis

NGP Paper

The relationship between multiple deprivation and severity of glaucoma at diagnosis

Author(s): Thai Ling Wong (1), Juan Lyn Ang (2), Sundeep Deol (2), Fiona Buckmaster (1), Alice D. McTrusty (1) and Andrew J. Tatham (1,2) 1 Centre...

March 30, 2023