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Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma
Purpose: To investigate the relationship between optic disc vessel density (ODVD) reduction and...
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Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects
It may be tempting to make a glaucoma diagnosis in the presence of a nerve fibre bundle defect...
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Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition
Purpose: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence...
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Not every ring scotoma is due to glaucoma
In advanced stages of glaucoma, patients may present with an annular scotoma, also known as ring...
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Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression
Purpose: To examine the relationship between systemic arterial blood pressure (BP) and the rate...
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Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study
Prcis: Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control...
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Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study
Purpose: A cross-sectional pilot study to compare macular oxygen saturation (sO2) and associated...
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Childhood Glaucoma
SIG Corner Editor: Hana Abouzeid Chair: Esther Hoffmann Co-chair: Zeynep Aktas Childhood glaucoma...
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Avoid premature removal of the intraluminal suture in glaucoma drainage devices to minimize the risk of hypotony
While prolene suture removal is an effective method for reducing IOP at the slit-lamp, removing...
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Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains
Purpose: (1) To assess whether neural tissue structure and biomechanics could predict functional...
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Validation of a Visual Field Prediction Tool for Glaucoma: A Multicenter Study Involving Patients With Glaucoma in the United Kingdom
Purpose: A previously developed machine-learning approach with Kalman filtering technology...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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When intraocular pressure lowering does not halt visual field progression in an eye which has classic features of glaucoma (glaucoma cupping, retinal nerve fiber loss and normal visual acuity and colour vision), a diagnosis of compressive optic neuropathy should be considered. While disc pallor is recognised to be a sign of potential ominous disease, it should be appreciated that in the early stages of compressive optic neuropathy, the disc may maintain its normal colour
The Science behind the Tip Axonal loss decreases the volume of the disc, and if loss is concentrated in one area without significant gliosis,...
December 31, 2019
Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs
Author(s): Jammal AA (1), Thompson AC (2), Mariottoni EB (2), Berchuck SI (3), Urata CN (2), Estrela T (2), Wakil SM (2), Costa VP (4), Medeiros FA...
December 31, 2019
Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma
Author(s): Fischer RA (1), Risner ML (2,3), Roux AL (2), Wareham LK (2), Sappington RM (1,2,3) 1 Department of Pharmacology, Vanderbilt University,...
December 31, 2019
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Intravenous Hypertonic Saline to Lower Intraocular Pressure in Ocular Hypertension and Primary Open-angle and Exfoliation Glaucoma
Author(s): Pia Katriina Inborr (1), Mika Harju, Tero T Kivelä Department of Ophthalmology, Helsinki University Hospital and University of Helsinki,...
December 30, 2019
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The Ocular Hypertension Treatment Study (OHTS)
Pearls Manager: Andrew Tatham The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...
December 20, 2019
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How should we define target intraocular pressure?
Pearls Manager: Andrew Tatham Target IOP is the upper limit of IOP estimated to be compatible with a rate of progression sufficiently slow to...
December 02, 2019
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While adherence to therapy is undoubtedly important, at least equally important is the patient’s adherence to a prescribed follow up schedule. Therapies can fail over time and missing follow up appointments can be particularly hazardous for fast progressors-practitioners should stress the importance of good follow up
The Science behind the Tip Clinical trials have shown us average rates of progression and average ideal IOP readings for populations of patients...
November 30, 2019
Glaucoma management in the era of artificial intelligence
Author(s): Devalla SK (1), Liang Z (1), Pham TH (1,2), Boote C (1,3,4), Strouthidis NG (2,5,6), Thiery AH (7), Girard MJA (8,2) 1 Department of...
November 30, 2019
Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine
Author(s): Khatib TZ (1,2,3), Martin KR (1,2,4,5,6,7) 1 John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of...
November 30, 2019
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Glaucoma following childhood cataract surgery
Pearls Manager: Andrew Tatham Secondary glaucoma is a frequent serious complication after cataract surgery in early infancy. The incidence may...
November 30, 2019
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Consider using a topical NSAID, or steroid, post SLT laser
The Science behind the Tip There is widespread variation in post laser treatment regimes. In a recent randomized, double-masked, multi-center...
October 31, 2019
Exogenous influences on intraocular pressure
Author(s): Kim YW (1), Park KH (2) 1 Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. 2 Ophthalmology, Seoul National...
October 31, 2019
Cholinergic nervous system and glaucoma: From basic science to clinical applications
Author(s): Faiq MA (1), Wollstein G (1), Schuman JS (1), Chan KC (2) 1 Department of Ophthalmology, New York University (NYU) School of Medicine,...
October 31, 2019
Ocular Blood Flow SIG
SIG Corner Editor: João Barbosa Breda Chair: Leopold Schmetterer Co-chair: Luis Abegão Pinto 1. Ongoing projects The Ocular Blood Flow SIG and its...
October 24, 2019
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Gonioscopy is essential for evaluating patients with a suspected or confirmed diagnosis of glaucoma
Pearls Manager: Andrew Tatham The corneal wedge method is helpful for identifying Schwalbe’s line, a collagen condensation of the Descemet’s...
October 22, 2019
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Consider additional 10-2 visual field testing for diagnosing glaucoma, as limiting to 24-2 or 30-2 tests will frequently miss or underestimate paracentral field defects
The Science behind the Tip (1,2) It is well-established that damage to macular retinal ganglion cells (RGCs) occurs early in glaucoma (1). Not...
September 30, 2019
Predictors of Neovascular Glaucoma in Central Retinal Vein Occlusion
Author(s): Rong AJ (1), Swaminathan SS (2), Vanner EA (3), Parrish RK 2nd (3) 1 Department of Ophthalmology, Bascom Palmer Eye Institute,...
September 30, 2019
microRNA dysregulation in neurodegenerative diseases: A systematic review
Author(s): Juźwik CA (1), Sage-Drake S (2), Zhang Y (3), Paradis-Isler N (4), Sylvester A (5), Amar-Zifkin A (6), Douglas C (7), Morquette B (8),...
September 30, 2019
Genetic Epidemiology SIG
SIG Corner Editor: João Barbosa Breda Chair: Ananth Viswanathan Co-chair: Fotis Topouzis NGP Co-chair: Anthony Khawaja NGP Co-chair: Panayiota...
September 30, 2019
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Clinical examination of the optic nerve head
Pearls Manager: Andrew Tatham Cup/disc ratio (CDR) depends on optic disc size. A large CDR in an eye with a normal large disc may be erroneously...
September 30, 2019
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When performing a laser peripheral iridotomy (LPI) for primary angle closure the position of the iridotomy in relation to the eyelid should always be considered
The Science behind the Tip (1,2,3) The incidence of reported dysphotopsias after an LPI varies from 2% to 11% with linear dysphotopsia and...
July 31, 2019
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Avoid the use of monocular prostaglandin analogue medication
The Science behind the Tip Where glaucoma predominantly affects one eye, monocular therapy may be used. Prostaglandin analogues are widely used as...
July 31, 2019
Effect of trabeculectomy on corneal endothelial cell loss
Author(s): Hirooka K (1), Nitta E (2), Ukegawa K (2), Sato S (2), Kiuchi Y (3) 1 Ophthalmology and Visual Science, Hiroshima University, Hiroshima,...
July 31, 2019
Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma
Author(s): Pérez de Lara MJ (1), Avilés-Trigueros M (2), Guzmán-Aránguez A (1), Valiente-Soriano FJ (2), de la Villa P (3), Vidal-Sanz M (4),...
July 31, 2019
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Adherence to glaucoma medication
Pearls Manager: Andrew Tatham Obstacles to glaucoma medication adherence include; 1) situational and environmental factors such as major life...
July 30, 2019