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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Artificial intelligence and deep learning in ophthalmology
Author(s): Ting DSW (1), Pasquale LR (2), Peng L (3), Campbell JP (4), Lee AY (5), Raman R (6), Tan GSW (7), Schmetterer L (7,8,9,10), Keane PA...
March 31, 2019
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Pigmentary glaucoma
Pearls Manager: Andrew Tatham Pigmentary glaucoma represents 1 to 1.5% of all glaucoma cases. It is more common in Caucasian myopic men and is...
March 30, 2019
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Depression may follow a diagnosis of chronic glaucoma, but depressive symptoms are less likely to be present one year later
The Science behind the Tip It is common for a newly-diagnosed patient with glaucoma to experience symptoms of depression (1,2). Patients who are...
March 01, 2019
The Effects of Optic Nerve Head Tilt on Visual Field Defects in Myopic Normal Tension Glaucoma: The Inter-eye Comparison Study
Author(s): Choi JH (1), Han JC, Kee C 1 Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,...
February 28, 2019
Identification of Candidate miRNA Biomarkers for Glaucoma
Author(s): Hindle AG1, Thoonen R2, Jasien JV (3), Grange RMH (1), Amin K (4), Wise J (4), Ozaki M (5), Ritch R (3), Malhotra R (2), Buys ES (1) 1...
February 28, 2019
Care Delivery SIG
SIG Corner Editor: João Barbosa Breda Chair: Anton B. Hommer Co-chair: Gabor Holló Update on ongoing projects The goal of this SIG is to get a...
February 28, 2019
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How to perform Goldmann applanation tonometry in patients with significant regular corneal astigmatism
Pearls Manager: Andrew Tatham When performing Goldmann applanation tonometry in patients with significant regular corneal astigmatism (>3...
February 20, 2019
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Early bleb revision usually results in successful resolution of hypotony maculopathy after trabeculectomy with mitomycin C
The Science behind the Tip Hypotony maculopathy is characterized by painless loss of vision usually more than three months after glaucoma...
January 31, 2019
Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review
Author(s): Patel P (1), Harris A (1), Toris C (2), Tobe L (1), Lang M (1), Belamkar A (1), Ng A (1), Verticchio Vercellin AC (3,4), Mathew S (1),...
January 31, 2019
Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma
Author(s): Mathieu E (1,2,3), Gupta N (1,2,3,4,5), Paczka-Giorgi LA (1,2), Zhou X (1,2), Ahari A (1,2), Lani R (1), Hanna J (1,2,3), Yücel YH...
January 31, 2019
Next Generation Partnership SIG
IG Corner Editor: João Barbosa Breda Chair: Gauti Jóhannesson Co-chairs: Esther Hoffmann, Francesco Oddone, Anthony Khawaja 1. Update on ongoing...
January 24, 2019
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Children using topical corticosteroids for the treatment of allergic conjunctivitis must have their intraocular pressure regularly checked
The Science behind the Tip 30-40% of the population respond to topical steroids by increasing their IOP (1). A steroid response is commonly found...
December 31, 2018
Artificial intelligence and deep learning in ophthalmology
Author(s): Ting DSW (1), Pasquale LR (2), Peng L (3), Campbell JP (4), Lee AY (5), Raman R (6), Tan GSW (7), Schmetterer L (7,8,9,10), Keane PA...
December 31, 2018
Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review
Author(s): Sabel BA (1), Flammer J (2), Merabet LB (3) 1 Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University of...
December 31, 2018
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Exfoliative glaucoma is the most common type of secondary open angle glaucoma
Pearls Manager: Andrew Tatham It develops in approximately 15 to 26% of eyes with exfoliation syndrome within 5 years and frequently causes severe...
December 30, 2018
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The results of trabeculectomy with mitomycin C are significantly improved in children with glaucoma secondary to juvenile idiopathic arthritis if they are on immune-modulatory treatment
The Science behind the Tip Juvenile idiopathic arthritis (JIA) is the most common systemic disease associated with childhood anterior uveitis....
November 30, 2018
Familial Risks of Glaucoma in the Population of Sweden
Author(s): Li X (1), Sundquist J (1,2,3), Zöller B (1), Sundquist K (1,2,3) 1 Center for Primary Health Care Research, Lund University, Sweden. 2...
November 30, 2018
Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma
Author(s): Singh LN (1), Crowston JG (2), Lopez Sanchez MIG (2), Van Bergen NJ (2), Kearns LS (2), Hewitt AW (2,3), Yazar S (4,5), Mackey DA (4),...
November 30, 2018
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Do you know how to stage an angle closure?
Pearls Manager: Andrew Tatham Primary Angle-Closure Suspect (PACS) - Two or more quadrants of iridotrabecular contact (lTC), normal IOP, no PAS, no...
November 23, 2018
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Microperimetry may be a more sensitive method of detecting a small glaucomatous defect close to fixation, than standard automated perimetry and OCT analysis of the retinal nerve fibre layer (RNFL)
The Science behind the Tip Microperimetry is a form of fundus-tracking perimetry that can detect reduced retinal sensitivity close to fixation more...
October 31, 2018
The Magnitude of IOP Elevation Associated with Eye Rubbing
Author(s): Turner DC (1), Girkin CA (2), Downs JC (3) 1 Department of Vision Sciences, School of Optometry, University of Alabama at Birmingham,...
October 31, 2018
Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma
Author(s): Bosco A(1), Anderson SR(2), Breen KT(2), Romero CO(2), Steele MR(2), Chiodo VA(3), Boye SL(3), Hauswirth WW(3), Tomlinson S(4), Vetter...
October 31, 2018
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When to perform a prophylactic iridotomy?
Pearls Manager: Andrew Tatham An international group of experts reached a consensus that 2 quadrants or more of ITC is an indication for...
October 22, 2018
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A glaucoma drainage device may be more effective than trabeculectomy in lowering IOP after keratoplasty, but is more likely to result in graft failure
The Science behind the Tip A well-controlled intraocular pressure (IOP) after penetrating keratoplasty (PK) is essential for graft survival and to...
September 30, 2018
Structural reversal of disc cupping after trabeculectomy alters Bruch's membrane opening-based parameters to assess neuroretinal rim
Author(s): Gietzelt C (1), Lemke J (1), Schaub F (1), Hermann MM (1), Dietlein TS (1), Cursiefen C (1), Enders P (2), Heindl LM (1) 1 Department of...
September 30, 2018