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Consider a concomitant neurological disease in a glaucoma patient when there is only partial topographic agreement between structure and function.
The Science behind the Tip One of the key elements in the diagnosis and monitoring of glaucoma is...
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Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition
Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with...
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Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss
Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction
The Science behind the Tip The enzyme carbonic anhydrase is present in the corneal endothelium where it is involved in fluid transport (1). It thus...
September 30, 2012
Practical landmarks for visual field disability in glaucoma
Author(s): Saunders LJ, Russell RA, Crabb DP. City University London, London, UK. BACKGROUND/AIMS: To assess whether mean deviation (MD) from...
September 30, 2012
siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice
Author(s): Liu Q, Wu K, Qiu X, Yang Y, Lin X, Yu M Few reports described efficient transfection in the trabecular meshwork (TM) in vivo. In the...
September 30, 2012
The Relationship Between Statin Use and Open-Angle Glaucoma
Author(s): Stein JD, Newman-Casey PA, Talwar N, Nan B, Richards JE, Musch DC. Department of Ophthalmology and Visual Sciences, University of...
July 31, 2012
Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma
Author(s): Fortune B, Burgoyne CF, Cull GA, Reynaud J, Wang L. Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research...
July 31, 2012
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In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function
The Science behind the Tip A recent study has shown that visual function is more likely to be preserved with brimonidine 2% than with timolol 0.5%...
June 30, 2012
Do patients with glaucoma have difficulty recognising faces?
Author(s): Glen FC, Crabb DP, Smith ND, Burton R, Garway-Heath DF. Department of Optometry and Visual Science, City University London, Northampton...
June 30, 2012
IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma
Author(s): Gallego BI, Salazar JJ, de Hoz R, Rojas B, Ramírez AI, Salinas-Navarro M, Ortín-Martínez A, Valiente-Soriano FJ, Avilés-Trigueros M,...
June 30, 2012
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A dry eye can hamper visual field test interpretation
The Science behind the Tip During visual field (VF) testing the cornea of patients with severe dry eye condition can get dry to such an extent as...
May 31, 2012
Prevalence of cognitive impairment, depression, and anxiety symptoms among older adults with glaucoma
Author(s): Yochim BP, Mueller AE, Kane KD, Kahook MY. Department of Psychology, University of Colorado at Colorado Springs, Colorado Springs...
May 31, 2012
JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death
Author(s): Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT. Flaum Eye Institute, University of Rochester...
May 31, 2012
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Laser peripheral iridotomy can reduce the intraocular pressure in pigment dispersion syndrome, but may not prevent glaucoma
The Science behind the Tip Nd-YAG laser peripheral iridotomy (PI) eliminates the reverse pressure gradient and intermittent posterior bowing of the...
April 30, 2012
The effect of thin, thick, and normal corneas on Goldmann intraocular pressure measurements and correction formulae in individual eyes
Author(s): Park SJ, Ang GS, Nicholas S, Wells AP. Eye Department, Wellington Hospital, Capital and Coast District Health Board, Wellington, New...
April 30, 2012
Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma
Author(s): Killer HE, Miller NR, Flammer J, Meyer P, Weinreb RN, Remonda L, Jaggi GP. Kantonsspital Aarau, CH-5001 Aarau, Switzerland;...
April 30, 2012
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Gonioscopy should be performed using the minimal possible levels of illumination in order to reliably detect appositional angle closure
The Science behind the Tip Anterior chamber angle width varies dramatically with illumination (figure and video in ref. 1) (1,2). Visible...
March 31, 2012
Cataract surgery after trabeculectomy: the effect on trabeculectomy function
Author(s): Husain R, Liang S, Foster PJ, Gazzard G, Bunce C, Chew PT, Oen FT, Khaw PT, Seah SK, Aung T FRCS(Edin), Singapore National Eye Center,...
March 31, 2012
Multipotent Stem Cells from Trabecular Meshwork Become Phagocytic TM cells
Author(s): Du Y, Roh DS, Mann MM, Funderburgh ML, Funderburgh JL, Schuman JS. UPMC Eye Center, Ophthalmology and Visual Science Research Center,...
March 31, 2012
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Laser peripheral iridotomy does not usually result in long-term intraocular pressure control in patients with chronic angle-closure glaucoma
The Science behind the Tip The initial treatment of chronic angle-closure glaucoma is to undertake a laser peripheral iridotomy (PI) to prevent...
February 29, 2012
Outcomes of different management options for malignant glaucoma: a retrospective study
Author(s): Debrouwere V, Stalmans P, Van Calster J, Spileers W, Zeyen T, Stalmans I. Department of Ophthalmology, Kapucijnenvoer 33, 3000, Leuven,...
February 29, 2012
A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients Changes of Fractional Anisotropy Detected by 3T Diffusion Tensor Imaging
Author(s): Engelhorn T, Michelson G, Waerntges S, Hempel S, El-Rafei A, Struffert T, Doerfler A. Department of Neuroradiology, University of...
February 29, 2012
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Trial lens artifacts can be easily distinguished from glaucomatous field defects
The Science behind the Tip False depressions due to a misaligned trial lens or a lens holder which was placed too far from the patient's eye are...
January 31, 2012
Optic nerve sheath diameter in normal-tension glaucoma patients
Author(s): Jaggi GP, Miller NR, Flammer J, Weinreb RN, Remonda L, Killer HE. Kantonsspital Aarau, Buchserstrasse, CH-5001 Aarau, Switzerland;...
January 31, 2012
Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration
Author(s): Laliberté AM, Macpherson TC, Micks T, Yan A, Hill KA Department of Biology, The University of Western Ontario, London, Ontario N6A 5B7,...
January 31, 2012
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In neovascular glaucoma, the immediate injection of intravitreal bevacizumab (Avastin®) usually results in rapid regression of iris new vessels and pain relief
The Science behind the Tip Neovascular glaucoma is a devastating consequence of diseases like proliferative diabetic retinopathy and ischaemic...
December 31, 2011
The Association between Glaucomatous and Other Causes of Optic Neuropathy and Sleep Apnea.
Author(s): Stein JD, Kim DS, Mundy KM, Talwar N, Nan B, Chervin RD, Musch DC. Department of Ophthalmology and Visual Sciences, University of...
December 31, 2011