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  • Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

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    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate...

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  • A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

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    A foundation model for generalizable disease detection from retinal images

    A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health...

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  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

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    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation...

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  • Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

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    Beware of acute corneal oedema after SLT in selected patients

    Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT)...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Be aware of obstructive sleep apnoea as a risk factor for the development or progression of glaucoma

Tip of the month

Be aware of obstructive sleep apnoea as a risk factor for the development or progression of glaucoma

Obstructive sleep apnoea (OSA) affects almost 1 billion people aged 30-69 years worldwide, of which 425 million have a moderate to severe OSA (1)....

January 31, 2023

Consider glaucoma drainage implant in patients with iridocorneal endothelial syndrome

Tip of the month

Consider glaucoma drainage implant in patients with iridocorneal endothelial syndrome

Glaucoma occurs in up to 70% of patients with iridocorneal endothelial syndrome (ICE) (1). Given the high failure rate of medical treatment,...

December 30, 2022

Estimating the Length of the Preclinical Detectable Phase for Open-Angle Glaucoma

Clinical paper of the month

Estimating the Length of the Preclinical Detectable Phase for Open-Angle Glaucoma

Author(s): Johan Aspberg (1,2), Anders Heijl (1,2), Boel Bengtsson (1) 1 Department of Clinical Sciences in Malmö, Ophthalmology, Lund University,...

December 29, 2022

Effect of trabeculectomy on the rate of progression of visual field damage

NGP Paper

Effect of trabeculectomy on the rate of progression of visual field damage

Author(s): Susanna Friederike Koenig (1,2), Giovanni Montesano (3,4), Clarissa Ern Hui Fang (5), David Paul Crabb (3), Hari Jayaram (5,4), Jonathan...

December 29, 2022

Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma

Experimental Paper of the Month

Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma

Author(s): Haojie Fu (1,2), Owen M Siggs (3,4), Lachlan Sw Knight (3), Sandra E Staffieri (5,6,7), Jonathan B Ruddle (7), Amy E Birsner (1), Edward...

December 29, 2022

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Tip of the month

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Publishing date: November 2022 Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia...

December 19, 2022

Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma

Clinical paper of the month

Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma

Author(s): Owen M Siggs (1,2), Ayub Qassim (1), Xikun Han (3), Henry N Marshall (1), Sean Mullany (1), Weixiong He (3), Emmanuelle Souzeau (1),...

November 30, 2022

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

Experimental Paper of the Month

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

Author(s): Alireza Karimi (1), Reza Razaghi (1), Seyed Mohammadali Rahmati (2), Christopher A Girkin (1), J Crawford Downs (1) 1 Department of...

November 30, 2022

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Tip of the month

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia and blepharospasm. The elevated...

November 30, 2022

Long-Term Alcohol Consumption and Risk of Exfoliation Glaucoma/Glaucoma Suspect among US Health Professionals

Clinical paper of the month

Long-Term Alcohol Consumption and Risk of Exfoliation Glaucoma/Glaucoma Suspect among US Health Professionals

Author(s): Akiko Hanyuda (1), Bernard A Rosner (2), Janey L Wiggs (3), Kazuno Negishi (4), Louis R Pasquale (5), Jae H Kang (6) 1 Department of...

October 31, 2022

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Experimental Paper of the Month

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Author(s): Yang Pan (1), Akiko Suga (1), Itaru Kimura (2), Chojiro Kimura (3), Yuriko Minegishi (1), Mao Nakayama (1), Kazutoshi Yoshitake (1),...

October 31, 2022

Consider evaluation of corneal endothelial cell count in pseudoexfoliation patients undergoing surgery

Tip of the month

Consider evaluation of corneal endothelial cell count in pseudoexfoliation patients undergoing surgery

Corneal endothelial cell loss may lead to corneal decompensation with loss of vision, which may necessitate future endothelial transplantation for...

October 31, 2022

Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change

Clinical paper of the month

Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change

Author(s): Fengbin Lin (1), Shida Chen (1), Yunhe Song (1), Fei Li (1), Wei Wang (1), Zhenni Zhao (2), Xinbo Gao (1), Peiyuan Wang (1), Ling Jin...

September 30, 2022

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

Experimental Paper of the Month

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

Author(s): Liang Li (1), Fang Fang (2), Xue Feng (1), Pei Zhuang (1), Haoliang Huang (1), Pingting Liu (1), Liang Liu (1), Adam Z Xu (3), Lei S Qi...

September 30, 2022

When glaucoma is not glaucoma

Tip of the month

When glaucoma is not glaucoma

An increased excavation of the optic nerve head is usually associated to glaucoma, but other optic neuropathies may also display an increased...

September 30, 2022

External Validation and Clinical Applicability of Two Optical Coherence Tomography-Based Risk Calculators for Detecting Glaucoma

NGP Paper

External Validation and Clinical Applicability of Two Optical Coherence Tomography-Based Risk Calculators for Detecting Glaucoma

Author(s): Néstor Ventura-Abreu (1), Marc Biarnés (2), Sofia Batlle-Ferrando (1), María Teresa Carrión-Donderis (1), Rafael Castro-Domínguez (1),...

September 30, 2022

Next Generation Partnership SIG

SIG Corner

Next Generation Partnership SIG

SIG Corner Editor: Hana Abouzeid Chair: Gauti Johannesson Co-chairs: Esther Hoffmann, Anthony Khawaja, Francesco Oddone The goal of this SIG is to...

July 31, 2022

Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial

Clinical paper of the month

Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial

Author(s): Nevin W El-Nimri (1), Sasan Moghimi (1), Rafaella C Penteado (1), Elham Ghahari (1), Diya Yang (2), Nicole Brye (1), James Proudfoot...

July 31, 2022

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

Experimental Paper of the Month

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

Author(s): Feng Tian (1), Yuyan Cheng (2), Songlin Zhou (1), Qianbin Wang (1), Aboozar Monavarfeshani (3), Kun Gao (2), Weiqian Jiang (1), Riki...

July 30, 2022

Be aware of IOP elevation in children treated with systemic glucocorticoids

Tip of the month

Be aware of IOP elevation in children treated with systemic glucocorticoids

Children have a high risk of developing IOP elevation with topical steroid-treatment, but may also develop it after systemic treatment (1–3). The...

July 30, 2022

Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Clinical paper of the month

Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Author(s): Roger Chou (1), Shelley Selph (1,2), Ian Blazina (1), Christina Bougatsos (1), Rebecca Jungbauer (1), Rongwei Fu (1,3), Sara Grusing...

June 30, 2022

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Experimental Paper of the Month

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Author(s): Cheng Yang (1), Qianni Wu (2), Junqing Liu (3), Jingshan Mo (1), Xiangling Li (1,4), Chengduan Yang (1,5), Ziqi Liu (1), Jingbo Yang...

June 30, 2022

UGH syndrome should be considered in every pseudophakic patient, with active unilateral inflammation and elevated intraocular pressure

Tip of the month

UGH syndrome should be considered in every pseudophakic patient, with active unilateral inflammation and elevated intraocular pressure

Uveitis-Glaucoma-Hyphaema (UGH) Syndrome is a rare syndrome characterized by iris transillumination defects, microhyphaemas and pigmentary...

June 30, 2022

Intravenous hypertonic saline to reduce intraocular pressure: the effect of splitting the bolus

NGP Paper

Intravenous hypertonic saline to reduce intraocular pressure: the effect of splitting the bolus

Author(s): Pia Inborr (1), Mika Harju (1), Tero T Kivelä (1) 1 Department of Ophthalmology, University of Helsinki and Helsinki University...

June 30, 2022

Hypotony-related complications, not numerical hypotony, should alarm the clinician

Tip of the month

Hypotony-related complications, not numerical hypotony, should alarm the clinician

Chronic hypotony, defined as a pressure of ≤5 mmHg for >3 months, may occur after glaucoma surgery (1,2). Despite being traditionally regarded...

May 31, 2022