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  • Tip: Not every peripapillary hemorrhage is a sign for glaucoma

    The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are related to the disease itself. Although the strong...

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    Tip: Not every peripapillary hemorrhage is a sign for glaucoma

    Tip: Not every peripapillary hemorrhage is a sign for glaucoma

    The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are...

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  • The Factors Affecting the Stability of IOP Homeostasis

    Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells provides a fast, IOP-sensitive feedback signal that...

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    The Factors Affecting the Stability of IOP Homeostasis

    The Factors Affecting the Stability of IOP Homeostasis

    Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells...

    Learn more...
  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

    Learn more...
  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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The Factors Affecting the Stability of IOP Homeostasis

Experimental Paper of the Month

The Factors Affecting the Stability of IOP Homeostasis

Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells provides a fast, IOP-sensitive feedback signal that...

June 16, 2024

TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

Experimental Paper of the Month

TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

May 15, 2024

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Experimental Paper of the Month

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how...

April 15, 2024

A foundation model for generalizable disease detection from retinal images

Experimental Paper of the Month

A foundation model for generalizable disease detection from retinal images

Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

March 14, 2024

Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

Experimental Paper of the Month

Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide....

February 12, 2024

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

Experimental Paper of the Month

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...

January 15, 2024

Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering

Experimental Paper of the Month

Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering

Significance The “in silico–in vitro–in vivo” funnel holds significant potential for identifying targets to control cellular processes in research...

December 17, 2023

How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head

Experimental Paper of the Month

How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head

​ 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2Ophthalmic Engineering & Innovation Laboratory, Singapore Eye...

November 15, 2023

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Experimental Paper of the Month

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Author(s): Xikun Han 1,2,37 , Puya Gharahkhani 1,2,3,37, Andrew R. Hamel 4,5, Jue Sheng Ong 1, Miguel E. Rentería 2,3,6, Puja Mehta 4,5, Xianjun...

October 15, 2023

Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer

Experimental Paper of the Month

Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer

Author(s): Ronen E Mukamel (1), Robert E Handsaker (2), Maxwell A Sherman (3), Alison R Barton (4), Margaux L A Hujoel (5), Steven A McCarroll (6),...

September 15, 2023

Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Experimental Paper of the Month

Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

July 30, 2023

Ligand-induced activation and G protein coupling of prostaglandin F2α receptor

Experimental Paper of the Month

Ligand-induced activation and G protein coupling of prostaglandin F2α receptor

Author(s): Canrong Wu (1), Youwei Xu (2), Qian He (2), Dianrong Li (3), Jia Duan (2), Changyao Li (4,5), Chongzhao You (2), Han Chen (6), Weiliang...

June 30, 2023

Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia

Experimental Paper of the Month

Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia

Author(s): Mahmoud T KhalafAllah (1,2), Preston A Fuchs (3), Fred Nugen (3), Mustapha El Hamdaoui (3), Alexander Levy (4), David T Redden (5),...

May 31, 2023

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma

Experimental Paper of the Month

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma

Author(s): Jae H Kang (1), Oana Zeleznik (1), Lisa Frueh (1), Jessica Lasky-Su (1), A Heather Eliassen (1,2), Clary Clish (3), Bernard A Rosner...

April 01, 2023

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

Experimental Paper of the Month

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

Author(s): W Daniel Stamer (1), Kristin M Perkumas (1), Min H Kang (2), Mohammed Dibas (3), Michael R Robinson (3), Douglas J Rhee (2) 1 Department...

March 31, 2023

Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway

Experimental Paper of the Month

Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway

Author(s): Yunsheng Qiao (1), Zhongmou Sun (2), Chen Tan (1), Junyi Lai (1), Xinghuai Sun (1,3,4), Junyi Chen (1,3,4) 1 Department of Ophthalmology...

February 28, 2023

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance

Experimental Paper of the Month

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance

Author(s): Emmi Kapiainen (1,2,3), Harri Elamaa (1,2,3), Ilkka Miinalainen (2,3), Valerio Izzi (1,2,4,5), Lauri Eklund (1,2,3) 1 Oulu Center for...

January 31, 2023

Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma

Experimental Paper of the Month

Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma

Author(s): Haojie Fu (1,2), Owen M Siggs (3,4), Lachlan Sw Knight (3), Sandra E Staffieri (5,6,7), Jonathan B Ruddle (7), Amy E Birsner (1), Edward...

December 29, 2022

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

Experimental Paper of the Month

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

Author(s): Alireza Karimi (1), Reza Razaghi (1), Seyed Mohammadali Rahmati (2), Christopher A Girkin (1), J Crawford Downs (1) 1 Department of...

November 30, 2022

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Experimental Paper of the Month

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Author(s): Yang Pan (1), Akiko Suga (1), Itaru Kimura (2), Chojiro Kimura (3), Yuriko Minegishi (1), Mao Nakayama (1), Kazutoshi Yoshitake (1),...

October 31, 2022

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

Experimental Paper of the Month

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

Author(s): Liang Li (1), Fang Fang (2), Xue Feng (1), Pei Zhuang (1), Haoliang Huang (1), Pingting Liu (1), Liang Liu (1), Adam Z Xu (3), Lei S Qi...

September 30, 2022

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

Experimental Paper of the Month

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

Author(s): Feng Tian (1), Yuyan Cheng (2), Songlin Zhou (1), Qianbin Wang (1), Aboozar Monavarfeshani (3), Kun Gao (2), Weiqian Jiang (1), Riki...

July 30, 2022

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Experimental Paper of the Month

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Author(s): Cheng Yang (1), Qianni Wu (2), Junqing Liu (3), Jingshan Mo (1), Xiangling Li (1,4), Chengduan Yang (1,5), Ziqi Liu (1), Jingbo Yang...

June 30, 2022

Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion

Experimental Paper of the Month

Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion

Author(s): Lili Xie (1,2), Ling-Ping Cen (1,2 3), Yiqing Li (1,2,4), Hui-Ya Gilbert (1,2), Oleksandr Strelko (1,2), Cynthia Berlinicke (5,6,7,8),...

May 31, 2022

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Experimental Paper of the Month

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Author(s): Nathan Ingold (1,2), Adrian I Campos (1,3), Xikun Han (1,3), Jue-Sheng Ong (1), Puya Gharahkhani (1), David A Mackey (4), Miguel E...

April 30, 2022