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Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life
The Science behind the Tip In contrast to underdiagnosis, which has been described in...
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Peripapillary Retinoschisis in Glaucoma: A Systematic Review
PURPOSE: The frequent use of optical coherence tomography increased the detection of...
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Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Purpose: To determine whether primary trabeculectomy or medical treatment produces better...
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Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension
Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...
September 01, 2021
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In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked
Angle recession (AR) is a common complication after a blunt ocular trauma, and it is related to a higher risk of developing late-onset glaucoma...
July 31, 2021
Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma
Author(s): Erin A Boese (1), Wallace L M Alward (2), John H Fingert (2) Department Ophthalmology and Visual Sciences, Carver College of Medicine,...
July 31, 2021
A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure
Author(s): Guorong Li (1), Astrid F Nottebaum (2), Mitchell Brigell (3), Iris D Navarro (1), Ute Ipe (2), Sarthak Mishra (2), Maria Gomez-Caraballo...
July 31, 2021
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Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial
Pearls Manager: Hari Jayaram Patients newly diagnosed with Primary Angle Closure Glaucoma without advanced damage or Primary Angle Closure with IOP...
July 30, 2021
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Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good
Charles Bonnet syndrome (CBS) describes the presence of complex visual hallucinations with retained insight in the unreal nature of the phenomenon...
June 30, 2021
Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study
Author(s): N Douglas Baker (1), Howard S Barnebey (2), Marlene R Moster (3), Michael C Stiles (4), Steven D Vold (5), Anup K Khatana (6), Brian E...
June 30, 2021
Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma
Author(s): Pinkal D Patel (1), Yen-Lin Chen (2), Ramesh B Kasetti (1), Prabhavathi Maddineni (1), William Mayhew (1), J Cameron Millar (1), Dorette...
June 30, 2021
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Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data
Author(s): Giovanni Montesano (1), Harry A Quigley (2), David P Crabb (3) 1 City, University of London Optometry and Visual Sciences (G.M.,...
June 30, 2021
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Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial
Pearls Manager: Hari Jayaram Newly diagnosed patients with Ocular Hypertension or Open Angle Glaucoma were randomised to one of two treatment...
June 30, 2021
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Consider focal pressure in case of poor filtration shortly after trabeculectomy
Achieving a good filtration in the early postoperative period after trabeculectomy is associated with the procedure's long-term success (1)....
May 31, 2021
Ten-Year Clinical Outcomes of Acute Primary Angle Closure Randomized to Receive Early Phacoemulsification Versus Laser Peripheral Iridotomy
Author(s): Poemen P Chan (1,2), Fang Y Tang (1), Dexter Y Leung (1,3), Thomas C Lam (1,2), Nafees Baig (1,4,3), Clement C Tham (1,2,5) 1 Department...
May 31, 2021
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Author(s): Puya Gharahkhani (1), Eric Jorgenson (2), Pirro Hysi (3), Anthony P Khawaja (4,5), Sarah Pendergrass (6) et al. 1 QIMR Berghofer Medical...
May 31, 2021
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Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial
Pearls Manager: Hari Jayaram The ZAP study was a single-centre randomised clinical trial performed in China to compare Laser Peripheral Iridotomy...
May 30, 2021
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Ganglion cell-inner plexiform layer examination can help diagnose glaucoma in high myopia
Myopia can be associated with significant structural changes in the eye, including peripapillary atrophy, myopic macular degeneration and the...
April 30, 2021
Quality of Life in Primary Open-Angle Glaucoma and Cataract: An Analysis of VFQ-25 and OSDI from the iStent inject® Pivotal Trial
Author(s): Thomas W Samuelson (1), Inder Paul Singh (2), Blake K Williamson (3), Heather Falvey (4), Won Chan Lee (5), Dawn Odom (6), David...
April 30, 2021
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye
Author(s): Genetics of Exfoliation Syndrome Partnership For a full list of authors and affiliations please visit...
April 30, 2021
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Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study
Pearls Manager: Hari Jayaram The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...
April 30, 2021
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My personal way to estimate whether a patient is at risk for wipeout following glaucoma surgery, is to perform a confrontation visual field with a red-topped bottle
This should be done monocularly with the bottle moved from the area of scotoma towards fixation. One must ensure that the patient is constantly...
March 31, 2021
Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS
Author(s): Veselina Petrova (1), Craig S Pearson (2), Jared Ching (3,4,5), James R Tribble (6), Andrea G Solano (2), Yunfei Yang (5), Fiona M Love...
March 31, 2021
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Correlations Between Subjective Evaluation of Quality of Life, Visual Field Loss, and Performance in Simulated Activities of Daily Living in Glaucoma Patients
Author(s): Line Azoulay-Sebban (1), Zhanlin Zhao (2,3), Ariel Zenouda (1), Marco Lombardi (1,4), Emmanuel Gutman (1), Emmanuelle Brasnu (4),...
March 30, 2021
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Patient Co-operation is Essential to Achieve IOP-Lowering and Successful Outcomes
Pearls Manager: Hari Jayaram Adherence and continued usage of (“persistence”) prescribed glaucoma management is necessary to achieve sustained IOP...
March 30, 2021
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Glaucoma associated with retinal detachment
Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...
March 20, 2021
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Consider IOP monitoring and prophylactic treatment in patients undergoing repeat intravitreal anti-VEGF injections
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections are now in widespread use for a plethora of retinal diseases. It is...
February 28, 2021
Anatomical Changes and Predictors of Angle Widening After Laser Peripheral Iridotomy: The Zhongshan Angle Closure Prevention Trial
Author(s): Benjamin Y Xu (1), David S Friedman (2), Paul J Foster (3), Yu Jiang (4), Anmol A Pardeshi (5), Yuzhen Jiang (4), Beatriz Munoz (6), Tin...
February 28, 2021