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Tip: Not every peripapillary hemorrhage is a sign for glaucoma
The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are...
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The Factors Affecting the Stability of IOP Homeostasis
Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells...
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Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study
Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice
Author(s): Liu Q, Wu K, Qiu X, Yang Y, Lin X, Yu M Few reports described efficient transfection in the trabecular meshwork (TM) in vivo. In the...
September 30, 2012
Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma
Author(s): Fortune B, Burgoyne CF, Cull GA, Reynaud J, Wang L. Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research...
July 31, 2012
IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma
Author(s): Gallego BI, Salazar JJ, de Hoz R, Rojas B, Ramírez AI, Salinas-Navarro M, Ortín-Martínez A, Valiente-Soriano FJ, Avilés-Trigueros M,...
June 30, 2012
JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death
Author(s): Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT. Flaum Eye Institute, University of Rochester...
May 31, 2012
Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma
Author(s): Killer HE, Miller NR, Flammer J, Meyer P, Weinreb RN, Remonda L, Jaggi GP. Kantonsspital Aarau, CH-5001 Aarau, Switzerland;...
April 30, 2012
Multipotent Stem Cells from Trabecular Meshwork Become Phagocytic TM cells
Author(s): Du Y, Roh DS, Mann MM, Funderburgh ML, Funderburgh JL, Schuman JS. UPMC Eye Center, Ophthalmology and Visual Science Research Center,...
March 31, 2012
A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients Changes of Fractional Anisotropy Detected by 3T Diffusion Tensor Imaging
Author(s): Engelhorn T, Michelson G, Waerntges S, Hempel S, El-Rafei A, Struffert T, Doerfler A. Department of Neuroradiology, University of...
February 29, 2012
Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration
Author(s): Laliberté AM, Macpherson TC, Micks T, Yan A, Hill KA Department of Biology, The University of Western Ontario, London, Ontario N6A 5B7,...
January 31, 2012
IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?
Author(s): Sigal IA, Yang H, Roberts MD, Grimm JL, Burgoyne CF, Demirel S, Downs JC. Ocular Biomechanics Laboratory. PURPOSE: To study the...
December 31, 2011
Genetic architecture of open angle glaucoma and related determinants
Author(s): Ramdas WD, Amin N, van Koolwijk LM, Janssens AC, Demirkan A, de Jong PT, Aulchenko YS, Wolfs RC, Hofman A, Rivadeneira F, Uitterlinden...
December 31, 2011
Identification of a Novel Locus for Autosomal Dominant Primary Open Angle Glaucoma on 4q35.1-q35.2.
Author(s): Porter LF, Urquhart JE, O'Donoghue E, Spencer AF, Wade EM, Manson FD, Black GC. School of Biomedicine, The University of Manchester,...
November 30, 2011
24-Hour IOP Telemetry in the Non-human Primate: Implant System Performance and Initial Characterization of IOP At Multiple Timescales
Author(s): Downs JC, Burgoyne CF, Seigfreid WP, Reynaud JF, Strouthidis NG, Sallee V. Ocular Biomechanics Laboratory, Devers Eye Institute,...
October 31, 2011
Activated retinal glia mediated axon regeneration in experimental glaucoma
Author(s): Lorber B, Guidi A, Fawcett JW, Martin KR. Centre for Brain Repair, University of Cambridge, Cambridge, UK. Glaucoma, a leading cause of...
September 30, 2011
During Glaucoma, {alpha}2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection
Author(s): Bai Y, Sivori D, Woo SB, Neet KE, Lerner SF, Saragovi HU Lady Davis Institute-Jewish General Hospital PURPOSE: Glaucoma is an optic...
August 31, 2011
Ex vivo optical coherence tomography imaging of collector channels with a scanning endoscopic probe
Author(s): Ren J, Gille HK, Wu J, Yang C. Departments of Electrical Engineering and. PURPOSE: To achieve high-fidelity optical coherence tomography...
July 31, 2011
Distortion of axonal cytoskeleton: an early sign of glaucomatous damage
Author(s): Huang X, Kong W, Zhou Y, Gregori G. PURPOSE: Glaucoma damages the retinal nerve fiber layer (RNFL). The purpose of this study was to...
June 30, 2011
Elastic modulus determination of normal and glaucomatous human trabecular meshwork
Author(s): Last JA, Pan T, Ding Y, Reilly CM, Keller K, Acott TS, Fautsch MP, Murphy CJ, Russell P. Department of Chemical and Biological...
May 31, 2011
Early Gene Expression Changes in the Retinal Ganglion Cell Layer of a Rat Glaucoma Model
Author(s): Guo Y, Johnson EC, Cepurna WO, Dyck J, Doser T, Morrison JC. Ophthalmology, Oregon Health & Sciences University, Portland, United...
April 30, 2011
Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT)
Author(s): Hann CR, Bentley MD, Vercnocke A, Ritman EL, Fautsch MP Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN...
March 31, 2011
Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma
Author(s): Comes N, Buie LK, Borrás T. Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. The...
February 28, 2011
Reversal of retinal ganglion cell dysfunction after surgical reduction of intraocular pressure
Author(s): Sehi M, Grewal DS, Goodkin ML, Greenfield DS. Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller...
January 31, 2011
Qualitative and quantitative morphologic changes in the vasculature and extracellular matrix of the prelaminar optic nerve head in eyes with POAG
Author(s): Tektas OY, Lütjen-Drecoll E, Scholz M Institute of Anatomy II, University of Erlangen-Nuremberg, Erlangen, Germany....
November 30, 2010
Functional MRI signal changes in primary visual cortex corresponding to the central normal visual field of patients with primary open-angle glaucoma
Author(s): Qing G, Zhang S, Wang B, Wang N Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology...
October 31, 2010
Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve
Author(s): Dahlmann-Noor A, Vijay S, Jayaram H, Limb A, Khaw PT. The 3 most common causes of visual impairment and legal blindness in developed...
September 30, 2010
Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility
Author(s): Writing Committee fot the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society, Meguro A, Inoko H, Ota M, Mizuki N,...
August 31, 2010