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  • Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible...

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    Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with...

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  • Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all licensed treatments lower IOP. However, many patients...

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    Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Glaucoma management in the era of artificial intelligence

Clinical paper of the month

Glaucoma management in the era of artificial intelligence

Author(s): Devalla SK (1), Liang Z (1), Pham TH (1,2), Boote C (1,3,4), Strouthidis NG (2,5,6), Thiery AH (7), Girard MJA (8,2) 1 Department of...

November 30, 2019

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Experimental Paper of the Month

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Author(s): Khatib TZ (1,2,3), Martin KR (1,2,4,5,6,7) 1 John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of...

November 30, 2019

Glaucoma following childhood cataract surgery

Pearl

Glaucoma following childhood cataract surgery

Pearls Manager: Andrew Tatham Secondary glaucoma is a frequent serious complication after cataract surgery in early infancy. The incidence may...

November 30, 2019

Consider using a topical NSAID, or steroid, post SLT laser

Tip of the month

Consider using a topical NSAID, or steroid, post SLT laser

The Science behind the Tip There is widespread variation in post laser treatment regimes. In a recent randomized, double-masked, multi-center...

October 31, 2019

Exogenous influences on intraocular pressure

Clinical paper of the month

Exogenous influences on intraocular pressure

Author(s): Kim YW (1), Park KH (2) 1 Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. 2 Ophthalmology, Seoul National...

October 31, 2019

Cholinergic nervous system and glaucoma: From basic science to clinical applications

Experimental Paper of the Month

Cholinergic nervous system and glaucoma: From basic science to clinical applications

Author(s): Faiq MA (1), Wollstein G (1), Schuman JS (1), Chan KC (2) 1 Department of Ophthalmology, New York University (NYU) School of Medicine,...

October 31, 2019

Ocular Blood Flow SIG

SIG Corner

Ocular Blood Flow SIG

SIG Corner Editor: João Barbosa Breda Chair: Leopold Schmetterer Co-chair: Luis Abegão Pinto 1. Ongoing projects The Ocular Blood Flow SIG and its...

October 24, 2019

Gonioscopy is essential for evaluating patients with a suspected or confirmed diagnosis of glaucoma

Pearl

Gonioscopy is essential for evaluating patients with a suspected or confirmed diagnosis of glaucoma

Pearls Manager: Andrew Tatham The corneal wedge method is helpful for identifying Schwalbe’s line, a collagen condensation of the Descemet’s...

October 22, 2019

Consider additional 10-2 visual field testing for diagnosing glaucoma, as limiting to 24-2 or 30-2 tests will frequently miss or underestimate paracentral field defects

Tip of the month

Consider additional 10-2 visual field testing for diagnosing glaucoma, as limiting to 24-2 or 30-2 tests will frequently miss or underestimate paracentral field defects

The Science behind the Tip (1,2) It is well-established that damage to macular retinal ganglion cells (RGCs) occurs early in glaucoma (1). Not...

September 30, 2019

Predictors of Neovascular Glaucoma in Central Retinal Vein Occlusion

Clinical paper of the month

Predictors of Neovascular Glaucoma in Central Retinal Vein Occlusion

Author(s): Rong AJ (1), Swaminathan SS (2), Vanner EA (3), Parrish RK 2nd (3) 1 Department of Ophthalmology, Bascom Palmer Eye Institute,...

September 30, 2019

microRNA dysregulation in neurodegenerative diseases: A systematic review

Experimental Paper of the Month

microRNA dysregulation in neurodegenerative diseases: A systematic review

Author(s): Juźwik CA (1), Sage-Drake S (2), Zhang Y (3), Paradis-Isler N (4), Sylvester A (5), Amar-Zifkin A (6), Douglas C (7), Morquette B (8),...

September 30, 2019

Genetic Epidemiology SIG

SIG Corner

Genetic Epidemiology SIG

SIG Corner Editor: João Barbosa Breda Chair: Ananth Viswanathan Co-chair: Fotis Topouzis NGP Co-chair: Anthony Khawaja NGP Co-chair: Panayiota...

September 30, 2019

Clinical examination of the optic nerve head

Pearl

Clinical examination of the optic nerve head

Pearls Manager: Andrew Tatham Cup/disc ratio (CDR) depends on optic disc size. A large CDR in an eye with a normal large disc may be erroneously...

September 30, 2019

When performing a laser peripheral iridotomy (LPI) for primary angle closure the position of the iridotomy in relation to the eyelid should always be considered

Tip of the month

When performing a laser peripheral iridotomy (LPI) for primary angle closure the position of the iridotomy in relation to the eyelid should always be considered

The Science behind the Tip (1,2,3) The incidence of reported dysphotopsias after an LPI varies from 2% to 11% with linear dysphotopsia and...

July 31, 2019

Avoid the use of monocular prostaglandin analogue medication

Tip of the month

Avoid the use of monocular prostaglandin analogue medication

The Science behind the Tip Where glaucoma predominantly affects one eye, monocular therapy may be used. Prostaglandin analogues are widely used as...

July 31, 2019

Effect of trabeculectomy on corneal endothelial cell loss

Clinical paper of the month

Effect of trabeculectomy on corneal endothelial cell loss

Author(s): Hirooka K (1), Nitta E (2), Ukegawa K (2), Sato S (2), Kiuchi Y (3) 1 Ophthalmology and Visual Science, Hiroshima University, Hiroshima,...

July 31, 2019

Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma

Experimental Paper of the Month

Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma

Author(s): Pérez de Lara MJ (1), Avilés-Trigueros M (2), Guzmán-Aránguez A (1), Valiente-Soriano FJ (2), de la Villa P (3), Vidal-Sanz M (4),...

July 31, 2019

Adherence to glaucoma medication

Pearl

Adherence to glaucoma medication

Pearls Manager: Andrew Tatham Obstacles to glaucoma medication adherence include; 1) situational and environmental factors such as major life...

July 30, 2019

Surgery SIG

SIG Corner

Surgery SIG

SIG Corner Editor: João Barbosa Breda Chair: Julián Garcia-Feijoo Co-chair: Keith Barton 1. Ongoing projects SURGERY REGISTRY The European Glaucoma...

July 26, 2019

Prevalence of Treatment With Glaucoma Medication in Scotland, 2010-2017

NGP Paper

Prevalence of Treatment With Glaucoma Medication in Scotland, 2010-2017

Author(s): Alan P Rotchford (1), John Hughes (2), Pankaj Kumar Agarwal (3), Andrew J Tatham (3) Ophthalmology, Tennent Institute of Ophthalmology,...

July 20, 2019

A glaucoma patient who progresses despite presumed good adherence might be using inadequate or insufficient technique when applying the anti-glaucomatous eye drops

Tip of the month

A glaucoma patient who progresses despite presumed good adherence might be using inadequate or insufficient technique when applying the anti-glaucomatous eye drops

The Science behind the Tip It is well known that if poor technique is used when a drop is applied to the eye it does not reach its target. This can...

June 30, 2019

Risk factors for disease progression in low-teens normal-tension glaucoma

Clinical paper of the month

Risk factors for disease progression in low-teens normal-tension glaucoma

Author(s): Baek SU (1,2), Ha A (3,4), Kim DW (5,6), Jeoung JW (3,4), Park KH (3,4), Kim YK (7,4) 1 Department of Ophthalmology, Hallym University...

June 30, 2019

Impact of Posterior Sclera on Glaucoma Progression in Treated Myopic Normal-Tension Glaucoma Using Reconstructed Optical Coherence Tomographic Images

Experimental Paper of the Month

Impact of Posterior Sclera on Glaucoma Progression in Treated Myopic Normal-Tension Glaucoma Using Reconstructed Optical Coherence Tomographic Images

Author(s): Kim YC (1), Koo YH (2), Jung KI (3), Park CK (3) 1 Department of Ophthalmology, College of Medicine, Incheon St. Mary's Hospital, The...

June 30, 2019

Glaucoma due to corticosteroids

Pearl

Glaucoma due to corticosteroids

Pearls Manager: Andrew Tatham Topical, intravitreal or systemic corticosteroids can induce acute or chronic intraocular pressure elevation. Risk...

June 30, 2019