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Consider a concomitant neurological disease in a glaucoma patient when there is only partial topographic agreement between structure and function.
The Science behind the Tip One of the key elements in the diagnosis and monitoring of glaucoma is...
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Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition
Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with...
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Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss
Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?
Author(s): Sigal IA, Yang H, Roberts MD, Grimm JL, Burgoyne CF, Demirel S, Downs JC. Ocular Biomechanics Laboratory. PURPOSE: To study the...
December 31, 2011
Genetic architecture of open angle glaucoma and related determinants
Author(s): Ramdas WD, Amin N, van Koolwijk LM, Janssens AC, Demirkan A, de Jong PT, Aulchenko YS, Wolfs RC, Hofman A, Rivadeneira F, Uitterlinden...
December 31, 2011
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Washout periods vary significantly between glaucoma medications
The Science behind the Tip Knowledge of the washout periods for topical medications is crucial for the evaluation of the effects of their...
November 30, 2011
Shrinkage of the scleral canal during cupping reversal in children.
Author(s): Mochizuki H, Lesley AG, Brandt JD. Department of Ophthalmology and Vision Science, University of California, Davis; Department of...
November 30, 2011
Identification of a Novel Locus for Autosomal Dominant Primary Open Angle Glaucoma on 4q35.1-q35.2.
Author(s): Porter LF, Urquhart JE, O'Donoghue E, Spencer AF, Wade EM, Manson FD, Black GC. School of Biomedicine, The University of Manchester,...
November 30, 2011
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To prevent early hypotony with a non-valved aqeous shunt, always occlude the tube with a suture
The Science behind the Tip The safe use of non-valved aqueous shunt implants, such as the Baerveldt (Advanced Medical Optics, Inc., Irvine,...
October 31, 2011
Intraocular Pressure Control and Long-term Visual Field Loss in the Collaborative Initial Glaucoma Treatment Study
Author(s): Musch DC, Gillespie BW, Niziol LM, Lichter PR, Varma R; CIGTS Study Group. Department of Ophthalmology and Visual Sciences, University...
October 31, 2011
24-Hour IOP Telemetry in the Non-human Primate: Implant System Performance and Initial Characterization of IOP At Multiple Timescales
Author(s): Downs JC, Burgoyne CF, Seigfreid WP, Reynaud JF, Strouthidis NG, Sallee V. Ocular Biomechanics Laboratory, Devers Eye Institute,...
October 31, 2011
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Prostaglandin analogues should be avoided in patients with a history of herpes keratitis
The Science behind the Tip Topical prostaglandins are commonly used as first-line and second-line therapy in patients with ocular hypertension and...
September 30, 2011
Vision loss and recovery after trabeculectomy: risk and associated risk factors
Author(s): Francis BA, Hong B, Winarko J, Kawji S, Dustin L, Chopra V. Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine,...
September 30, 2011
Activated retinal glia mediated axon regeneration in experimental glaucoma
Author(s): Lorber B, Guidi A, Fawcett JW, Martin KR. Centre for Brain Repair, University of Cambridge, Cambridge, UK. Glaucoma, a leading cause of...
September 30, 2011
Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma
Author(s): Ren R, Wang N, Zhang X, Cui T, Jonas JB Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital,...
August 31, 2011
During Glaucoma, {alpha}2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection
Author(s): Bai Y, Sivori D, Woo SB, Neet KE, Lerner SF, Saragovi HU Lady Davis Institute-Jewish General Hospital PURPOSE: Glaucoma is an optic...
August 31, 2011
Lifestyle and risk of developing open-angle glaucoma: the Rotterdam study
Author(s): Ramdas WD, Wolfs RC, Hofman A, de Jong PT, Vingerling JR, Jansonius NM. Department of Ophthalmology, Erasmus Medical Center Rotterdam,...
July 31, 2011
Ex vivo optical coherence tomography imaging of collector channels with a scanning endoscopic probe
Author(s): Ren J, Gille HK, Wu J, Yang C. Departments of Electrical Engineering and. PURPOSE: To achieve high-fidelity optical coherence tomography...
July 31, 2011
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Rim/disc ratio is a more sensitive parameter than cup/disc ratio
The Science behind the Tip Routine fundus observation of the optic disc is helpful in the diagnosis of early glaucoma and it is often key in the...
June 30, 2011
Risk factors for visual field progression in treated glaucoma
Author(s): De Moraes CG, Juthani VJ, Liebmann JM, Teng CC, Tello C, Susanna R Jr, Ritch R. OBJECTIVE: To determine intraocular pressure...
June 30, 2011
Distortion of axonal cytoskeleton: an early sign of glaucomatous damage
Author(s): Huang X, Kong W, Zhou Y, Gregori G. PURPOSE: Glaucoma damages the retinal nerve fiber layer (RNFL). The purpose of this study was to...
June 30, 2011
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In patients with juvenile-onset chronic open-angle glaucoma, trabeculectomy with mitomycin C is usually required to prevent progressive visual loss
The Science behind the Tip Juvenile-onset chronic open-angle glaucoma is inherited in an autosomal dominant fashion with high penetrance....
May 31, 2011
The Relationship Between Components of Metabolic Syndrome and Open-Angle Glaucoma
Author(s): Newman-Casey PA, Talwar N, Nan B, Musch DC, Stein JD. Department of Ophthalmology and Visual Sciences, University of Michigan Medical...
May 31, 2011
Elastic modulus determination of normal and glaucomatous human trabecular meshwork
Author(s): Last JA, Pan T, Ding Y, Reilly CM, Keller K, Acott TS, Fautsch MP, Murphy CJ, Russell P. Department of Chemical and Biological...
May 31, 2011
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The advantage of adding a 3rd or 4th drug may be negligible
The Science behind the Tip With the arrival of combination products, our threshold for prescribing multiple glaucoma medications has significantly...
April 30, 2011
A Randomized Trial of Brimonidine Versus Timolol in Preserving Visual Function: Results From the Low-pressure Glaucoma Treatment Study
Author(s): Krupin T, Liebmann JM, Greenfield DS, Ritch R, Gardiner S. Department of Ophthalmology, Feinberg School of Medicine, Northwestern...
April 30, 2011
Early Gene Expression Changes in the Retinal Ganglion Cell Layer of a Rat Glaucoma Model
Author(s): Guo Y, Johnson EC, Cepurna WO, Dyck J, Doser T, Morrison JC. Ophthalmology, Oregon Health & Sciences University, Portland, United...
April 30, 2011
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The most effective treatment of glaucoma associated with epithelial downgrowth is to insert a drainage implant
The Science behind the Tip Epithelial downgrowth into the anterior chamber is an extremely rare cause of glaucoma after anterior segment incisional...
March 31, 2011