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  • Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible...

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    Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with...

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  • Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all licensed treatments lower IOP. However, many patients...

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    Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

    Learn more...
  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Unilateral ocular hypertension: have a look at the corneal endothelium

Tip of the month

Unilateral ocular hypertension: have a look at the corneal endothelium

Unilateral ocular hypertension or glaucoma is often associated with secondary causes that should be explored to ascertain the visual prognosis and...

January 31, 2022

Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer

Clinical paper of the month

Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer

Author(s): Christopher Kai Shun Leung (1,2,3,4), Alexander Ka Ngai Lam (5), Robert Neal Weinreb (6), David F Garway-Heath (7), Marco Yu (8), Philip...

January 31, 2022

Phase 1b Randomized Controlled Study of Short Course Topical Recombinant Human Nerve Growth Factor (rhNGF) for Neuroenhancement in Glaucoma: Safety, Tolerability, and Efficacy Measure Outcomes

Experimental Paper of the Month

Phase 1b Randomized Controlled Study of Short Course Topical Recombinant Human Nerve Growth Factor (rhNGF) for Neuroenhancement in Glaucoma: Safety, Tolerability, and Efficacy Measure Outcomes

Author(s): Gala Beykin (1), Laurel Stell (1), Muhammad Sohail Halim (1), Mariana Nuñez (1), Lilia Popova (1), Bac T Nguyen (1), Sylvia L Groth (1),...

January 31, 2022

Mind the depth – forward displacement of the lens-iris diaphragm and myopic shift after ophthalmic surgery is suggestive of aqueous misdirection

Tip of the month

Mind the depth – forward displacement of the lens-iris diaphragm and myopic shift after ophthalmic surgery is suggestive of aqueous misdirection

Aqueous misdirection is a serious condition with potentially higher prevalence than expected. Predominantly observed after ocular surgery,...

December 31, 2021

Attitudes towards polygenic risk testing in individuals with glaucoma

Clinical paper of the month

Attitudes towards polygenic risk testing in individuals with glaucoma

Author(s): Georgina L Hollitt (1), Owen M Siggs (2), Bronwyn Ridge (2), Miriam C Keane (2), David A Mackey (3), Stuart MacGregor (4), Alex W Hewitt...

December 31, 2021

Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies

Experimental Paper of the Month

Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies

Author(s): Benjamin R Thomson (1,2), Pan Liu (1,2), Tuncer Onay (1), Jing Du (1,2), Stuart W Tompson (3), Sol Misener (1,2), Raj R Purohit (1,2),...

December 31, 2021

Virtual Reality-Based and Conventional Visual Field Examination Comparison in Healthy and Glaucoma Patients

NGP Paper

Virtual Reality-Based and Conventional Visual Field Examination Comparison in Healthy and Glaucoma Patients

Author(s): Jan Stapelfeldt (1), Serife Seda Kucur (1), Nina Huber (1), René Höhn (2), Raphael Sznitman (1) 1 ARTORG Center for Biomedical...

December 30, 2021

Exfoliation (pseudoexfoliation) syndrome (with or without glaucoma) is associated with clinically significant non-vascular systemic diseases

Tip of the month

Exfoliation (pseudoexfoliation) syndrome (with or without glaucoma) is associated with clinically significant non-vascular systemic diseases

The association of systemic vascular dysfunction and vascular diseases with exfoliation syndrome have been extensively studied in the last decades....

December 01, 2021

Association Between Visual Field Damage and Gait Dysfunction in Patients With Glaucoma

Clinical paper of the month

Association Between Visual Field Damage and Gait Dysfunction in Patients With Glaucoma

Author(s): Jian-Yu E (1,2), Aleksandra Mihailovic (1), Catalina Garzon (1), Jennifer A Schrack (2,3), Tianjing Li (4), Sheila K West (1), Laura N...

November 30, 2021

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Experimental Paper of the Month

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Author(s): K Saidas Nair (# 1), Chitrangda Srivastava (# 2), Robert V Brown (# 2), Swanand Koli (3), Hélène Choquet (4), Hong Soon Kang (2),...

November 30, 2021

Unplanned Return to the Operating Room After Trabeculectomy

Clinical paper of the month

Unplanned Return to the Operating Room After Trabeculectomy

Author(s): Nur Cardakli (1), David S Friedman (2), Michael V Boland (3) 1 Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins...

November 30, 2021

Exfoliation SIG

SIG Corner

Exfoliation SIG

The goal of this SIG is to increase ophthalmologists’ knowledge on XFS and XFG, and to support the optimal clinical care in XFG in Europe. 1....

November 01, 2021

Consider trabeculectomy as initial treatment for newly diagnosed advanced primary open angle glaucoma (POAG)

Tip of the month

Consider trabeculectomy as initial treatment for newly diagnosed advanced primary open angle glaucoma (POAG)

IOP control is of uttermost importance in advanced glaucoma to prevent blindness. The EGS guidelines recommend IOP in the low teens, e.g. 10-12mmHg...

October 31, 2021

In vivo imaging of the Schlemm's Canal and the response to Selective laser trabeculoplasty

Clinical paper of the month

In vivo imaging of the Schlemm's Canal and the response to Selective laser trabeculoplasty

Author(s): Toshit Varshney (1), Kishan Azmira (1), Shikha Gupta (1), Karthikeyan Mahalingam (1), Abhishek Singh (1), Dewang Angmo (1), Viney Gupta...

October 31, 2021

Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

Experimental Paper of the Month

Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

Author(s): 1 Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 2 Department of Neuroscience, Yale...

October 31, 2021

Take a look at the deviation maps when assessing structural change in glaucoma

Tip of the month

Take a look at the deviation maps when assessing structural change in glaucoma

The structural analysis of the thickness of peripapillary retinal nerve fiber layer (pRNFL) and the inner layers of the posterior pole with optical...

September 30, 2021

Long-Term Outcomes of Selective Laser Trabeculoplasty for Open-Angle Glaucoma in the Caribbean

Clinical paper of the month

Long-Term Outcomes of Selective Laser Trabeculoplasty for Open-Angle Glaucoma in the Caribbean

Author(s): Tony Realini (1), Hazel Shillingford-Ricketts (2), Darra Burt (3), Goundappa K Balasubramani (4) 1 West Virginia University Eye...

September 30, 2021

Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury

Experimental Paper of the Month

Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury

Author(s): Ling-Ping Cen (1), Tsz Kin Ng (1,2,3), Jia-Jian Liang (1), Ciyan Xu (1), Xi Zhuang (1), Yu-Fen Liu (1,2), Shao-Lang Chen (1), Yanxuan Xu...

September 30, 2021

The glaucoma intensive treatment study: interim results from an ongoing longitudinal randomized clinical trial

NGP Paper

The glaucoma intensive treatment study: interim results from an ongoing longitudinal randomized clinical trial

Author(s): Boel Bengtsson (1), Christina Lindén (2), Anders Heijl (1), Sabina Andersson-Geimer (1), Johan Aspberg (1), Gauti Jóhannesson (2,3) 1...

September 30, 2021

Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

Pearl

Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

September 01, 2021

In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked

Tip of the month

In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked

Angle recession (AR) is a common complication after a blunt ocular trauma, and it is related to a higher risk of developing late-onset glaucoma...

July 31, 2021

Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma

Clinical paper of the month

Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma

Author(s): Erin A Boese (1), Wallace L M Alward (2), John H Fingert (2) Department Ophthalmology and Visual Sciences, Carver College of Medicine,...

July 31, 2021

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Experimental Paper of the Month

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Author(s): Guorong Li (1), Astrid F Nottebaum (2), Mitchell Brigell (3), Iris D Navarro (1), Ute Ipe (2), Sarthak Mishra (2), Maria Gomez-Caraballo...

July 31, 2021

Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial

Pearl

Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial

Pearls Manager: Hari Jayaram Patients newly diagnosed with Primary Angle Closure Glaucoma without advanced damage or Primary Angle Closure with IOP...

July 30, 2021

Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good

Tip of the month

Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good

Charles Bonnet syndrome (CBS) describes the presence of complex visual hallucinations with retained insight in the unreal nature of the phenomenon...

June 30, 2021