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Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis
Purpose: Compare different methods to deliver Mitomycin C (MMC) in trabeculectomy surgery....
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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study
Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...
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Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma
Purpose: To investigate the relationship between optic disc vessel density (ODVD) reduction and...
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Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects
It may be tempting to make a glaucoma diagnosis in the presence of a nerve fibre bundle defect...
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Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition
Purpose: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence...
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Not every ring scotoma is due to glaucoma
In advanced stages of glaucoma, patients may present with an annular scotoma, also known as ring...
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Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression
Purpose: To examine the relationship between systemic arterial blood pressure (BP) and the rate...
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Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study
Prcis: Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control...
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Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study
Purpose: A cross-sectional pilot study to compare macular oxygen saturation (sO2) and associated...
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Childhood Glaucoma
SIG Corner Editor: Hana Abouzeid Chair: Esther Hoffmann Co-chair: Zeynep Aktas Childhood glaucoma...
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Avoid premature removal of the intraluminal suture in glaucoma drainage devices to minimize the risk of hypotony
While prolene suture removal is an effective method for reducing IOP at the slit-lamp, removing...
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Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains
Purpose: (1) To assess whether neural tissue structure and biomechanics could predict functional...
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Generic drops can differ from brand drops and it may be necessary to monitor patients more closely after switching
The Science behind the Tip In order to be approved for general use, a generic drug has to show the criterion of essential similarity when compared...
October 31, 2013
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The measurement of retinal nerve fibre thickness is helpful in determining which patients with ocular hypertension will develop glaucoma
The Science behind the Tip In patients with ocular hypertension, moderate to severe retinal nerve fibre layer (RNFL) atrophy at baseline has been...
September 30, 2013
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Post-traumatic angle-recession glaucoma is difficult to manage and surgical intervention is often required
The Science behind the Tip Anterior chamber angle recession is the commonest physical sign of previous blunt trauma to the eye. Raised intraocular...
June 30, 2013
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The use of Ginkgo biloba may increase the risk of bleeding
The Science behind the Tip Extracts of the leaves of the Asiatic tree Ginkgo biloba (GBE) provide protection against mitochondrial oxidative damage...
May 31, 2013
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If surgery is required to control IOP in a patient with nanophthalmos, phacoemulsification with IOL implantation is a good option, but the complication rate is high
The Science behind the Tip Nanophthalmos, small eye-big trouble, is a form of microophthalmos which is not accompanied by other congenital...
April 30, 2013
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Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed
The Science behind the Tip Malignant glaucoma or aqueous misdirection is a rare but feared complication of anterior segment surgery. It occurs in...
March 31, 2013
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Young men of European ancestry with angle-closure require thorough investigation
The Science behind the Tip Primary angle closure glaucoma is rare in younger white adults, with an estimated age specific prevalence of 0.02% for...
February 28, 2013
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Intravitreal steroids should be used with caution in patients with glaucoma
The Science behind the Tip In recent years it has become common practice to inject steroids into the vitreous to reduce macular oedema or ocular...
December 31, 2012
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Long-term application of benzalkonium chloride increases the risk of filtration surgery failure
The Science behind the Tip Glaucoma medication solutions usually contain the preservative benzalkonium chloride (BAK) in concentrations varying...
November 30, 2012
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In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure
The Science behind the Tip Raised intraocular pressure (IOP) in an eye with pseudoexfoliation syndrome results from pigment and exfoliation...
October 31, 2012
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Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction
The Science behind the Tip The enzyme carbonic anhydrase is present in the corneal endothelium where it is involved in fluid transport (1). It thus...
September 30, 2012
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In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function
The Science behind the Tip A recent study has shown that visual function is more likely to be preserved with brimonidine 2% than with timolol 0.5%...
June 30, 2012
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A dry eye can hamper visual field test interpretation
The Science behind the Tip During visual field (VF) testing the cornea of patients with severe dry eye condition can get dry to such an extent as...
May 31, 2012
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Laser peripheral iridotomy can reduce the intraocular pressure in pigment dispersion syndrome, but may not prevent glaucoma
The Science behind the Tip Nd-YAG laser peripheral iridotomy (PI) eliminates the reverse pressure gradient and intermittent posterior bowing of the...
April 30, 2012
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Gonioscopy should be performed using the minimal possible levels of illumination in order to reliably detect appositional angle closure
The Science behind the Tip Anterior chamber angle width varies dramatically with illumination (figure and video in ref. 1) (1,2). Visible...
March 31, 2012
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Laser peripheral iridotomy does not usually result in long-term intraocular pressure control in patients with chronic angle-closure glaucoma
The Science behind the Tip The initial treatment of chronic angle-closure glaucoma is to undertake a laser peripheral iridotomy (PI) to prevent...
February 29, 2012
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Trial lens artifacts can be easily distinguished from glaucomatous field defects
The Science behind the Tip False depressions due to a misaligned trial lens or a lens holder which was placed too far from the patient's eye are...
January 31, 2012
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In neovascular glaucoma, the immediate injection of intravitreal bevacizumab (Avastin®) usually results in rapid regression of iris new vessels and pain relief
The Science behind the Tip Neovascular glaucoma is a devastating consequence of diseases like proliferative diabetic retinopathy and ischaemic...
December 31, 2011
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Washout periods vary significantly between glaucoma medications
The Science behind the Tip Knowledge of the washout periods for topical medications is crucial for the evaluation of the effects of their...
November 30, 2011
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To prevent early hypotony with a non-valved aqeous shunt, always occlude the tube with a suture
The Science behind the Tip The safe use of non-valved aqueous shunt implants, such as the Baerveldt (Advanced Medical Optics, Inc., Irvine,...
October 31, 2011
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Prostaglandin analogues should be avoided in patients with a history of herpes keratitis
The Science behind the Tip Topical prostaglandins are commonly used as first-line and second-line therapy in patients with ocular hypertension and...
September 30, 2011
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Rim/disc ratio is a more sensitive parameter than cup/disc ratio
The Science behind the Tip Routine fundus observation of the optic disc is helpful in the diagnosis of early glaucoma and it is often key in the...
June 30, 2011
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In patients with juvenile-onset chronic open-angle glaucoma, trabeculectomy with mitomycin C is usually required to prevent progressive visual loss
The Science behind the Tip Juvenile-onset chronic open-angle glaucoma is inherited in an autosomal dominant fashion with high penetrance....
May 31, 2011
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The advantage of adding a 3rd or 4th drug may be negligible
The Science behind the Tip With the arrival of combination products, our threshold for prescribing multiple glaucoma medications has significantly...
April 30, 2011
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The most effective treatment of glaucoma associated with epithelial downgrowth is to insert a drainage implant
The Science behind the Tip Epithelial downgrowth into the anterior chamber is an extremely rare cause of glaucoma after anterior segment incisional...
March 31, 2011