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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Individualized glaucoma treatment

Pearl

Individualized glaucoma treatment

Pearls Manager: Andrew Tatham Individualized glaucoma treatment aims at providing glaucoma management tailored to the individual needs of the...

May 30, 2020

Exfoliation SIG

SIG Corner

Exfoliation SIG

Chair: Gabor Hollo Co-chair: Anastasios Konstas The goal of this SIG is to increase ophthalmologists’ knowledge on XFS and XFG, and to support the...

May 24, 2020

Late in-the-bag intraocular lens dislocation several years after uncomplicated cataract surgery is relatively common in pseudoexfoliation

Tip of the month

Late in-the-bag intraocular lens dislocation several years after uncomplicated cataract surgery is relatively common in pseudoexfoliation

The Science behind the Tip In pseudoexfoliation syndrome (PSX) and pseudoexfoliative glaucoma (PSG) progressive zonular damage frequently leads to...

March 31, 2020

The Association between Medication Adherence and Visual Field Progression in the Collaborative Initial Glaucoma Treatment Study

Clinical paper of the month

The Association between Medication Adherence and Visual Field Progression in the Collaborative Initial Glaucoma Treatment Study

Author(s): Newman-Casey PA (1), Niziol LM (2), Gillespie BW (3), Janz NK (4), Lichter PR (2), Musch DC (5) 1 Department of Ophthalmology and Visual...

March 31, 2020

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry

Experimental Paper of the Month

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry

Author(s): Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser MA (1,2,3,4), Allingham RR (2,3,4), Aung T (3,4,5,6), Van...

March 31, 2020

Care Delivery SIG

SIG Corner

Care Delivery SIG

SIG Corner Editor: João Barbosa Breda Chair: Anton B. Hommer Co-chair: Gábor Holló The goal of this SIG is to keep an updated overview of glaucoma...

March 31, 2020

Glaucoma Gel Implant Learning Curve in a Teaching Tertiary Hospital

NGP Paper

Glaucoma Gel Implant Learning Curve in a Teaching Tertiary Hospital

Author(s):* Raquel Esteves Marques (1,2), Nuno Pinto Ferreira (1,2), David Cordeiro Sousa (1,2,3), Joana Pinto (1,2), André Barata (1,2), Paula...

March 30, 2020

Glaucoma associated with retinal detachment

Pearl

Glaucoma associated with retinal detachment

Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...

March 30, 2020

Aniridia and Axenfeld-Rieger Syndrome: Clinical Presentations, Molecular Genetics and Current/Emerging Therapies

Clinical paper of the month

Aniridia and Axenfeld-Rieger Syndrome: Clinical Presentations, Molecular Genetics and Current/Emerging Therapies

Author(s): Paul W Chrystal (1), Michael A Walter (2) 1 Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada. 2 Department of...

February 29, 2020

Electrophysiology in Glaucoma

Experimental Paper of the Month

Electrophysiology in Glaucoma

Author(s): Senger C (1), Moreto R (1), Watanabe SES ()2, Matos AG (1), Paula JS (1) 1 Department of Ophthalmology, Otorhinolaryngology and Head and...

February 29, 2020

Consider Brinzolamide to prevent IOP Spikes after Cataract Surgery in Eyes with Glaucoma

Tip of the month

Consider Brinzolamide to prevent IOP Spikes after Cataract Surgery in Eyes with Glaucoma

The Science behind the Tip IOP spikes, i.e. an IOP elevation after surgery compared to baseline, often occur in eyes with glaucoma.2 IOP spikes may...

February 28, 2020

Visual Field Progression

Pearl

Visual Field Progression

Pearls Manager: Andrew Tatham Visual field progression analyses may be event or trend-based. Trend analyses quantify rate of progression, usually...

February 20, 2020

Next Generation Partnership SIG

SIG Corner

Next Generation Partnership SIG

SIG Corner Editor: João Barbosa Breda Chair: Gauti Jóhannesson Co-chairs: Esther Hoffmann, Francesco Oddone, Anthony Khawaja What is the NGP? The...

February 19, 2020

Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs

Clinical paper of the month

Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs

Author(s): Jammal AA (1), Thompson AC (2), Mariottoni EB (2), Berchuck SI (3), Urata CN (2), Estrela T (2), Wakil SM (2), Costa VP (4), Medeiros FA...

December 31, 2019

Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma

Experimental Paper of the Month

Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma

Author(s): Fischer RA (1), Risner ML (2,3), Roux AL (2), Wareham LK (2), Sappington RM (1,2,3) 1 Department of Pharmacology, Vanderbilt University,...

December 31, 2019

Intravenous Hypertonic Saline to Lower Intraocular Pressure in Ocular Hypertension and Primary Open-angle and Exfoliation Glaucoma

NGP Paper

Intravenous Hypertonic Saline to Lower Intraocular Pressure in Ocular Hypertension and Primary Open-angle and Exfoliation Glaucoma

Author(s): Pia Katriina Inborr (1), Mika Harju, Tero T Kivelä Department of Ophthalmology, Helsinki University Hospital and University of Helsinki,...

December 30, 2019

The Ocular Hypertension Treatment Study (OHTS)

Pearl

The Ocular Hypertension Treatment Study (OHTS)

Pearls Manager: Andrew Tatham The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...

December 20, 2019

How should we define target intraocular pressure?

Pearl

How should we define target intraocular pressure?

Pearls Manager: Andrew Tatham Target IOP is the upper limit of IOP estimated to be compatible with a rate of progression sufficiently slow to...

December 02, 2019

Glaucoma management in the era of artificial intelligence

Clinical paper of the month

Glaucoma management in the era of artificial intelligence

Author(s): Devalla SK (1), Liang Z (1), Pham TH (1,2), Boote C (1,3,4), Strouthidis NG (2,5,6), Thiery AH (7), Girard MJA (8,2) 1 Department of...

November 30, 2019

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Experimental Paper of the Month

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Author(s): Khatib TZ (1,2,3), Martin KR (1,2,4,5,6,7) 1 John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of...

November 30, 2019

Glaucoma following childhood cataract surgery

Pearl

Glaucoma following childhood cataract surgery

Pearls Manager: Andrew Tatham Secondary glaucoma is a frequent serious complication after cataract surgery in early infancy. The incidence may...

November 30, 2019

Consider using a topical NSAID, or steroid, post SLT laser

Tip of the month

Consider using a topical NSAID, or steroid, post SLT laser

The Science behind the Tip There is widespread variation in post laser treatment regimes. In a recent randomized, double-masked, multi-center...

October 31, 2019

Exogenous influences on intraocular pressure

Clinical paper of the month

Exogenous influences on intraocular pressure

Author(s): Kim YW (1), Park KH (2) 1 Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. 2 Ophthalmology, Seoul National...

October 31, 2019