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Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life
The Science behind the Tip In contrast to underdiagnosis, which has been described in...
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Peripapillary Retinoschisis in Glaucoma: A Systematic Review
PURPOSE: The frequent use of optical coherence tomography increased the detection of...
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Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Purpose: To determine whether primary trabeculectomy or medical treatment produces better...
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Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension
Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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When intraocular pressure lowering does not halt visual field progression in an eye which has classic features of glaucoma (glaucoma cupping, retinal nerve fiber loss and normal visual acuity and colour vision), a diagnosis of compressive optic neuropathy should be considered. While disc pallor is recognised to be a sign of potential ominous disease, it should be appreciated that in the early stages of compressive optic neuropathy, the disc may maintain its normal colour
The Science behind the Tip Axonal loss decreases the volume of the disc, and if loss is concentrated in one area without significant gliosis,...
December 31, 2019
Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs
Author(s): Jammal AA (1), Thompson AC (2), Mariottoni EB (2), Berchuck SI (3), Urata CN (2), Estrela T (2), Wakil SM (2), Costa VP (4), Medeiros FA...
December 31, 2019
Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma
Author(s): Fischer RA (1), Risner ML (2,3), Roux AL (2), Wareham LK (2), Sappington RM (1,2,3) 1 Department of Pharmacology, Vanderbilt University,...
December 31, 2019
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Intravenous Hypertonic Saline to Lower Intraocular Pressure in Ocular Hypertension and Primary Open-angle and Exfoliation Glaucoma
Author(s): Pia Katriina Inborr (1), Mika Harju, Tero T Kivelä Department of Ophthalmology, Helsinki University Hospital and University of Helsinki,...
December 30, 2019
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The Ocular Hypertension Treatment Study (OHTS)
Pearls Manager: Andrew Tatham The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...
December 20, 2019
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How should we define target intraocular pressure?
Pearls Manager: Andrew Tatham Target IOP is the upper limit of IOP estimated to be compatible with a rate of progression sufficiently slow to...
December 02, 2019
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While adherence to therapy is undoubtedly important, at least equally important is the patient’s adherence to a prescribed follow up schedule. Therapies can fail over time and missing follow up appointments can be particularly hazardous for fast progressors-practitioners should stress the importance of good follow up
The Science behind the Tip Clinical trials have shown us average rates of progression and average ideal IOP readings for populations of patients...
November 30, 2019
Glaucoma management in the era of artificial intelligence
Author(s): Devalla SK (1), Liang Z (1), Pham TH (1,2), Boote C (1,3,4), Strouthidis NG (2,5,6), Thiery AH (7), Girard MJA (8,2) 1 Department of...
November 30, 2019
Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine
Author(s): Khatib TZ (1,2,3), Martin KR (1,2,4,5,6,7) 1 John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of...
November 30, 2019
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Glaucoma following childhood cataract surgery
Pearls Manager: Andrew Tatham Secondary glaucoma is a frequent serious complication after cataract surgery in early infancy. The incidence may...
November 30, 2019
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Consider using a topical NSAID, or steroid, post SLT laser
The Science behind the Tip There is widespread variation in post laser treatment regimes. In a recent randomized, double-masked, multi-center...
October 31, 2019
Exogenous influences on intraocular pressure
Author(s): Kim YW (1), Park KH (2) 1 Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. 2 Ophthalmology, Seoul National...
October 31, 2019
Cholinergic nervous system and glaucoma: From basic science to clinical applications
Author(s): Faiq MA (1), Wollstein G (1), Schuman JS (1), Chan KC (2) 1 Department of Ophthalmology, New York University (NYU) School of Medicine,...
October 31, 2019
Ocular Blood Flow SIG
SIG Corner Editor: João Barbosa Breda Chair: Leopold Schmetterer Co-chair: Luis Abegão Pinto 1. Ongoing projects The Ocular Blood Flow SIG and its...
October 24, 2019
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Gonioscopy is essential for evaluating patients with a suspected or confirmed diagnosis of glaucoma
Pearls Manager: Andrew Tatham The corneal wedge method is helpful for identifying Schwalbe’s line, a collagen condensation of the Descemet’s...
October 22, 2019
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Consider additional 10-2 visual field testing for diagnosing glaucoma, as limiting to 24-2 or 30-2 tests will frequently miss or underestimate paracentral field defects
The Science behind the Tip (1,2) It is well-established that damage to macular retinal ganglion cells (RGCs) occurs early in glaucoma (1). Not...
September 30, 2019
Predictors of Neovascular Glaucoma in Central Retinal Vein Occlusion
Author(s): Rong AJ (1), Swaminathan SS (2), Vanner EA (3), Parrish RK 2nd (3) 1 Department of Ophthalmology, Bascom Palmer Eye Institute,...
September 30, 2019
microRNA dysregulation in neurodegenerative diseases: A systematic review
Author(s): Juźwik CA (1), Sage-Drake S (2), Zhang Y (3), Paradis-Isler N (4), Sylvester A (5), Amar-Zifkin A (6), Douglas C (7), Morquette B (8),...
September 30, 2019
Genetic Epidemiology SIG
SIG Corner Editor: João Barbosa Breda Chair: Ananth Viswanathan Co-chair: Fotis Topouzis NGP Co-chair: Anthony Khawaja NGP Co-chair: Panayiota...
September 30, 2019
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Clinical examination of the optic nerve head
Pearls Manager: Andrew Tatham Cup/disc ratio (CDR) depends on optic disc size. A large CDR in an eye with a normal large disc may be erroneously...
September 30, 2019
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When performing a laser peripheral iridotomy (LPI) for primary angle closure the position of the iridotomy in relation to the eyelid should always be considered
The Science behind the Tip (1,2,3) The incidence of reported dysphotopsias after an LPI varies from 2% to 11% with linear dysphotopsia and...
July 31, 2019
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Avoid the use of monocular prostaglandin analogue medication
The Science behind the Tip Where glaucoma predominantly affects one eye, monocular therapy may be used. Prostaglandin analogues are widely used as...
July 31, 2019
Effect of trabeculectomy on corneal endothelial cell loss
Author(s): Hirooka K (1), Nitta E (2), Ukegawa K (2), Sato S (2), Kiuchi Y (3) 1 Ophthalmology and Visual Science, Hiroshima University, Hiroshima,...
July 31, 2019
Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma
Author(s): Pérez de Lara MJ (1), Avilés-Trigueros M (2), Guzmán-Aránguez A (1), Valiente-Soriano FJ (2), de la Villa P (3), Vidal-Sanz M (4),...
July 31, 2019
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Adherence to glaucoma medication
Pearls Manager: Andrew Tatham Obstacles to glaucoma medication adherence include; 1) situational and environmental factors such as major life...
July 30, 2019