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Tip: Not every peripapillary hemorrhage is a sign for glaucoma
The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are...
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The Factors Affecting the Stability of IOP Homeostasis
Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells...
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Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study
Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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The Potential Association Between Postmenopausal Hormone Use and Primary Open-Angle Glaucoma
Author(s): Newman-Casey PA(1), Talwar N(1), Nan B(2), Musch DC(3), Pasquale LR(4), Stein JD(5). 1 Department of Ophthalmology and Visual Sciences,...
March 31, 2014
Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing
Author(s): Jeoung JW(1), Seong MW, Park SS, Kim DM, Kim SH, Park KH. 1 Department of Ophthalmology, Seoul National University Hospital, Seoul,...
March 31, 2014
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Perimetry should be undertaken soon after phacoemulsification and multifocal IOL implantation in patients with glaucoma, in order to establish new baseline parameters
The Science behind the Tip To determine change in visual function in patients with glaucoma, regular visual field testing is undertaken using...
February 28, 2014
Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection
Author(s): Santos-Carvalho A (1), Alvaro AR (2), Martins J (3), Ambrósio AF (4), Cavadas C (5) Neuropeptide Y (NPY) and NPY receptors are widely...
February 28, 2014
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The early diagnosis of glaucoma and early detection of glaucoma progression should be enhanced by the use of spectral domain OCT measurement of the neuro retinal rim
The Science behind the Tip Recent studies using spectral domain ocular coherence tomography (SD OCT) measurement of the optic disc margin show that...
January 31, 2014
The 5-Year Incidence of Bleb-Related Infection and Its Risk Factors after Filtering Surgeries with Adjunctive Mitomycin C: Collaborative Bleb-Related Infection Incidence and Treatment Study 2
Author(s): Yamamoto T (1), Sawada A (2), Mayama C (3), Araie M (3), Ohkubo S (4), Sugiyama K4, Kuwayama Y (5); The Collaborative Bleb-Related...
January 31, 2014
Relationship between Preferred Sleeping Position and Asymmetric Visual-field Loss in Open-angle Glaucoma Patients
Author(s): Kim KN(1), Jeoung JW(2), Park KH(3), Kim DM(4), Ritch R(5) 1 Department of Ophthalmology, Chungnam National University Hospital,...
January 31, 2014
Regulation of Plasticity and Fibrogenic Activity of Trabecular Meshwork Cells by Rho GTPase Signaling
Author(s): Pattabiraman PP, Maddala R, Rao PV. Department of Ophthalmology, Duke University School of Medicine, Durham, NC, 27710. Glaucoma, a...
January 31, 2014
Does optic nerve head surface topography change prior to loss of retinal nerve fiber layer thickness: a test of the site of injury hypothesis in experimental glaucoma
Author(s): Fortune B, Reynaud J, Wang L, Burgoyne CF. Discoveries in Sight Research Laboratories, Devers Eye Institute, and Legacy Research...
December 31, 2013
Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix production in Trabecular Meshwork and Lamina Cribrosa cells
Author(s): Wallace DM, Clark AF, Lipson K, Andrews D, Crean J, O'Brien CJ. PURPOSE: We have previously demonstrated elevated levels of Connective...
December 31, 2013
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Consider using preservative-free topical medication in patients with ocular surface disease
The Science behind the Tip Many glaucoma drops contain a preservative agent to minimise the risk of microbial contamination. Benzalconium chloride,...
November 30, 2013
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Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short
The Science behind the Tip Trabeculectomy surgery is a recognised risk factor for the subsequent development of cataract. Phacoemulsification with...
November 30, 2013
Pathogenesis and clinical implications of optic disk hemorrhage in glaucoma
Author(s): Suh MH, Park KH. Department of Ophthalmology, Haeundae Paik Hospital, Busan, Korea; Department of Ophthalmology, Inje University College...
November 30, 2013
Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome
Author(s): Johnson TV, Dekorver NW, Levasseur VA, Osborne A, Tassoni A, Lorber B, Heller JP, Villasmil R, Bull ND, Martin KR, Tomarev SI 1 Section...
November 30, 2013
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Generic drops can differ from brand drops and it may be necessary to monitor patients more closely after switching
The Science behind the Tip In order to be approved for general use, a generic drug has to show the criterion of essential similarity when compared...
October 31, 2013
Lifetime Risk of Blindness in Open-Angle Glaucoma
Author(s): Peters D, Bengtsson B, Heijl A Department of Ophthalmology, Lund University, Skåne University Hospital, Malmö, Sweden. Electronic...
October 31, 2013
Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmuneglaucoma
Author(s): Joachim SC, Reinehr S, Kuehn S, Laspas P, Gramlich OW, Kuehn M, Tischoff I, von Pein HD, Dick HB, Grus FH Experimental Eye Research...
October 31, 2013
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The measurement of retinal nerve fibre thickness is helpful in determining which patients with ocular hypertension will develop glaucoma
The Science behind the Tip In patients with ocular hypertension, moderate to severe retinal nerve fibre layer (RNFL) atrophy at baseline has been...
September 30, 2013
The Ahmed Versus Baerveldt Study: Three-Year Treatment Outcomes
Author(s): Christakis PG, Tsai JC, Kalenak JW, Zurakowski D, Cantor LB, Kammer JA, Ahmed II. Department of Ophthalmology and Vision Sciences,...
September 30, 2013
Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier than RNFL Thickness Changes in Experimental Glaucoma
Author(s): Fortune B, Burgoyne CF, Cull G, Reynaud J, Wang L. Devers Eye Institute, Legacy Research Institute, 1225 NE 2nd Avenue, 3rd Floor,...
September 30, 2013
Rho-associated kinase inhibitors: A novel glaucoma therapy
Author(s): Inoue T, Tanihara H. Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto, Japan....
July 31, 2013
Ocular Rigidity, Outflow facility, Ocular Pulse Amplitude and Pulsatile Ocular Blood Flow in Open AngleGlaucoma; a manometric study
Author(s): Dastiridou AI, Tsironi EE, Tsilimbaris M, Ginis H, Karyotakis N, Cholevas P, Androudi S, Pallikaris IG. Ophthalmology Department,...
July 31, 2013
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Post-traumatic angle-recession glaucoma is difficult to manage and surgical intervention is often required
The Science behind the Tip Anterior chamber angle recession is the commonest physical sign of previous blunt trauma to the eye. Raised intraocular...
June 30, 2013
Prevalence and Severity of Undetected Manifest Glaucoma: Results from the Early Manifest Glaucoma Trial Screening
Author(s): Heijl A, Bengtsson B, Oskarsdottir SE. Lund University, Department of Clinical Sciences Malmö, Ophthalmology, Skåne University Hospital,...
June 30, 2013
Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma
Author(s): Almasieh M, Macintyre JN, Pouliot M, Casanova C, Vaucher E, Kelly ME, Di Polo A. Department of Pathology and Cell Biology and Groupe de...
June 30, 2013