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Tip: Not every peripapillary hemorrhage is a sign for glaucoma
The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are...
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The Factors Affecting the Stability of IOP Homeostasis
Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells...
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Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study
Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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The use of Ginkgo biloba may increase the risk of bleeding
The Science behind the Tip Extracts of the leaves of the Asiatic tree Ginkgo biloba (GBE) provide protection against mitochondrial oxidative damage...
May 31, 2013
The eye and the heart
Author(s): Flammer J, Konieczka K, Bruno R M, Virdis A, Flammer A J, Taddei S The vasculature of the eye and the heart share several common...
May 31, 2013
Reduction in Blood Glutathione Levels Occurs Similarly in Patients with Primary-Open Angle or Normal Tension Glaucoma
Author(s): Gherghel D, Mroczkowska S, Qin L Vascular Research Laboratory, Ophthalmic Research Group, Aston University, School of Life and Health...
May 31, 2013
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If surgery is required to control IOP in a patient with nanophthalmos, phacoemulsification with IOL implantation is a good option, but the complication rate is high
The Science behind the Tip Nanophthalmos, small eye-big trouble, is a form of microophthalmos which is not accompanied by other congenital...
April 30, 2013
How Does Glaucoma Look?: Patient Perception of Visual Field Loss
Author(s): Crabb DP, Smith ND, Glen FC, Burton R, Garway-Heath DF Department of Optometry and Visual Science, City University London, London,...
April 30, 2013
Tissue engineering the retinal ganglion cell nerve fiber layer
Author(s): Kador KE, Montero RB, Venugopalan P, Hertz J, Zindell AN, Valenzuela DA, Uddin MS, Lavik EB, Muller KJ, Andreopoulos FM, Goldberg JL...
April 30, 2013
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Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed
The Science behind the Tip Malignant glaucoma or aqueous misdirection is a rare but feared complication of anterior segment surgery. It occurs in...
March 31, 2013
Treatment Outcomes in Malignant Glaucoma
Author(s): Dave P, Senthil S, Rao HL, Garudadri CS. L. V. Prasad Eye Institute, Hyderabad, India. PURPOSE: To report treatment outcomes in...
March 31, 2013
Discovery of novel human aquaporin-1 blockers
Author(s): Seeliger D, Zapater C, Krenc D, Haddoub R, Flitsch S, Beitz E, Cerdà J, de Groot BL. Human aquaporin-1 (hAQP1) is a water channel found...
March 31, 2013
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Young men of European ancestry with angle-closure require thorough investigation
The Science behind the Tip Primary angle closure glaucoma is rare in younger white adults, with an estimated age specific prevalence of 0.02% for...
February 28, 2013
Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cell line
Author(s): Koriyama Y, Nakayama Y, Matsugo S, Kato S. Department of Molecular Neurobiology, Graduate School of Medicine. Electronic address:...
February 28, 2013
Balance control in glaucoma
Author(s): Kotecha A, Richardson G, Chopra R, Fahy RT, Garway-Heath DF, Rubin GS Department of Visual Neuroscience, University College London (UCL)...
January 31, 2013
A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits
Author(s): Brignole-Baudouin F, Desbenoit N, Hamm G, Liang H, Both JP, Brunelle A, Fournier I, Guerineau V, Legouffe R, Stauber J, Touboul D,...
January 31, 2013
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Intravitreal steroids should be used with caution in patients with glaucoma
The Science behind the Tip In recent years it has become common practice to inject steroids into the vitreous to reduce macular oedema or ocular...
December 31, 2012
Factors that influence standard automated perimetry test results in glaucoma: test reliability, technician experience, time of day, and season
Author(s): Junoy Montolio FG, Wesselink C, Gordijn M, Jansonius NM Department of Ophthalmology, University Medical Center Groningen, University of...
December 31, 2012
Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient
Author(s): Samuels BC, Hammes NM, Johnson PL, Shekhar A, McKinnon SJ, Allingham RR Eugene and Marilyn Glick Eye Institute, the. PURPOSE:...
December 31, 2012
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Long-term application of benzalkonium chloride increases the risk of filtration surgery failure
The Science behind the Tip Glaucoma medication solutions usually contain the preservative benzalkonium chloride (BAK) in concentrations varying...
November 30, 2012
Retinal Vessel Caliber Is Associated with the 10-year Incidence of Glaucoma: The Blue Mountains Eye Study
Author(s): Kawasaki R, Wang JJ, Rochtchina E, Lee AJ, Wong TY, Mitchell P. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital,...
November 30, 2012
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Author(s): Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu L,...
November 30, 2012
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In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure
The Science behind the Tip Raised intraocular pressure (IOP) in an eye with pseudoexfoliation syndrome results from pigment and exfoliation...
October 31, 2012
Longitudinal effect of topical antiglaucoma medications on central corneal thickness
Author(s): Viswanathan D, Goldberg I, Graham SL Australian School of Advanced Medicine, Macquarie University, Sydney, Australia. BACKGROUND: To...
October 31, 2012
Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma
Author(s): Gardiner SK, Fortune B, Wang L, Downs JC, Burgoyne CF Devers Eye Institute, Legacy Health, 1225 NE 2nd Ave., Portland, OR 97232, USA....
October 31, 2012
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Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction
The Science behind the Tip The enzyme carbonic anhydrase is present in the corneal endothelium where it is involved in fluid transport (1). It thus...
September 30, 2012
Practical landmarks for visual field disability in glaucoma
Author(s): Saunders LJ, Russell RA, Crabb DP. City University London, London, UK. BACKGROUND/AIMS: To assess whether mean deviation (MD) from...
September 30, 2012
siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice
Author(s): Liu Q, Wu K, Qiu X, Yang Y, Lin X, Yu M Few reports described efficient transfection in the trabecular meshwork (TM) in vivo. In the...
September 30, 2012