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Tip: Not every peripapillary hemorrhage is a sign for glaucoma
The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are...
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The Factors Affecting the Stability of IOP Homeostasis
Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells...
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Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study
Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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The side effects of timolol and other beta-adrenergic antagonists on the cardiovascular and pulmonary system in predisposed patients should not be underestimated
Since 1976 beta-adrenergic antagonists have established their role in the effective lowering of the intraocular pressure. The potential side...
December 31, 2020
Risk Factors for Visual Field Deterioration in the United Kingdom Glaucoma Treatment Study
Author(s): Panayiota Founti (1), Catey Bunce (2), Anthony P Khawaja (3), Caroline J Doré (4), Jibran Mohamed-Noriega (3), David F Garway-Heath (3),...
December 31, 2020
Metabolomic profiling of aqueous humor from glaucoma patients - The metabolomics in surgical ophthalmological patients (MISO) study
Author(s): João Barbosa Breda (1), Anca Croitor Sava (2), Uwe Himmelreich (2), Alix Somers (3), Christophe Matthys (4), Amândio Rocha Sousa (5),...
December 31, 2020
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The Mont Blanc Study: The effect of altitude on intra ocular pressure and central corneal thickness
Author(s): Carlo Bruttini (1), Alice Verticchio Vercellin (1,2,3), Catherine Klersy (4), Annalisa De Silvestri (4), Carmine Tinelli (4), Ivano Riva...
December 30, 2020
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Optical coherence tomography for glaucoma diagnosis
Pearls Manager: Andrew Tatham Optical coherence tomography (OCT) on its own does not provide a clinical diagnosis of glaucoma, just a statistical...
December 30, 2020
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Trabecular meshwork bypass surgery should be avoided if high episcleral venous pressure is suspected
The intraocular pressure lowering effect of procedures that attempt to enhance flow of aqueous into Schlemm’s canal by bypassing or cutting the...
November 30, 2020
Neuroprotection SIG
SIG Corner Editor: João Barbosa Breda Chair: Francesca Cordeiro Co-chair: Miriam Kolko The goal of this SIG is to increase ophthalmologists’...
November 30, 2020
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Minimally invasive and micro incisional glaucoma surgery
Pearls Manager: Andrew Tatham Surgical procedures that entail less tissue manipulation with the expectation of a better safety profile and quicker...
November 30, 2020
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Haemodialysis can cause an acute rise in intraocular pressure
Haemodialysis (HD) can reportedly induce a sudden rise in intraocular pressure (IOP) in patients with neovascular (NVG) (1) and pseudo-exfoliative...
October 31, 2020
Longitudinal Macular Ganglion Cell-Inner Plexiform Layer Measurements to Detect Glaucoma Progression in High Myopia
Author(s): Joong Won Shin (1), Min Kyung Song (1), Kyung Rim Sung (2) 1 Department of Ophthalmology, College of Medicine, University of Ulsan, Asan...
October 31, 2020
Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases
Author(s): Bryn L Brazile (1), Bin Yang (1,2), Susannah Waxman (1) , Po Lam (1), Andrew P Voorhees (1), Yi Hua (1), Ralitsa T Loewen (1), Nils A...
October 31, 2020
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Malignant glaucoma
Pearls Manager: Andrew Tatham Malignant glaucoma or aqueous misdirection is a rare type of secondary angle closure glaucoma most commonly...
October 20, 2020
Angle Closure - Relevant breakthroughs in this field
2.1 Should laser peripheral iridotomy (LPI) be performed in primary angle-closure suspect (PACS) patients? Last year we covered the EAGLE and ZAP...
October 01, 2020
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Glaucoma progression: watch out the fellow, non-progressing eye
In clinical practice, the detection of visual field progression in one eye usually leads to management modifications in that eye. Less attention is...
September 30, 2020
Cardiovascular Disease may predict structural and functional progression in early glaucoma
Author(s): Henry Marshall (1), Sean Mullany (2), Ayub Qassim (2), Mark Hassall (2), Owen Siggs (2), Bronwyn Ridge (2), Thi Nguyen (2), Mona...
September 30, 2020
Association of Glaucoma Risk Genes with Retinal Nerve Fiber Layer in a Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study
Author(s): Xiaoran Chai (1,2,3), Kok Yao Low (1,4), Yih Chung Tham (1), Miao Li Chee (1), Sahil Thakur (1), Liang Zhang (1), Nicholas Y Tan (1),...
September 30, 2020
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Mutations in SPATA13/ASEF2 Cause Primary Angle Closure Glaucoma
Author(s): Naushin H Waseem (1), Sancy Low (2,3,4), Amna Z Shah (3), Deepa Avisetti (5), Pia Ostergaard (6), Michael Simpson (7), Katarzyna A...
September 30, 2020
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Optimising eye drop instillation
Pearls Manager: Andrew Tatham When two eye drops are instilled 30 seconds apart, almost 50% of the first drug will be washed out. It is recommended...
September 30, 2020
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Take care not to miss glaucomatous cupping in patients with small discs!
The Science behind the Tip The diagnosis of glaucoma can be missed in patients with small optic discs (1). In such patients, relative crowding of...
July 31, 2020
Longitudinal Macular Structure–Function Relationships in Glaucoma
Author(s): Vahid Mohammadzadeh (1), Alessandro Rabiolo (2), Qiang Fu (3), Esteban Morales (1), Anne L Coleman (1), Simon K Law (1), Joseph Caprioli...
July 31, 2020
Efficacy for Differentiating Nonglaucomatous Versus Glaucomatous Optic Neuropathy Using Deep Learning Systems
Author(s): Hee Kyung Yang (1), Young Jae Kim (2), Jae Yun Sung (1), Dong Hyun Kim (1), Kwang Gi Kim (3), Jeong-Min Hwang (4) 1 Department of...
July 31, 2020
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The Collaborative Normal Tension Glaucoma Study (CNTGS)
Pearls Manager: Andrew Tatham The CNTGS compared treatment versus no treatment in patients with normal tension glaucoma who had verified...
July 30, 2020
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Ask your glaucoma patients about mobility rather than vision
The Science behind the Tip Self-reported visual disability in glaucoma which correlates with level of visual field loss includes bumping into...
June 30, 2020
Visual Field Outcomes from the Multicenter, Randomized Controlled Laser in Glaucoma and Ocular Hypertension Trial
Author(s): David M.Wright (1,2), Evgenia Konstantakopoulou (3,4,5), Giovanni Montesano (6), Neil Nathwani (3), Anurag Garg (3), David Garway-Heath...
June 30, 2020
Using Deep Learning to Automate Goldmann Applanation Tonometry Readings
Author(s): Ted Spaide (1), Yue Wu (1), Ryan T Yanagihara (1), Shu Feng (1), Omar Ghabra (1), Jonathan S Yi (1), Philip P Chen (1), Francy Moses...
June 30, 2020