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  • Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible...

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    Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with...

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  • Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all licensed treatments lower IOP. However, many patients...

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    Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Regulation of intraocular pressure by microRNA cluster miR-143/145

Experimental Paper of the Month

Regulation of intraocular pressure by microRNA cluster miR-143/145

Author(s): Li X (1,2), Zhao F (3,4), Xin M (5), Li G (6), Luna C (6), Li G (1), Zhou Q (4), He Y (2), Yu B (4), Olson E (7), Gonzalez P (6), Wang S...

June 30, 2017

In a patient with glaucoma who has unexplained hair loss, stop topical beta-blocker treatment

Tip of the month

In a patient with glaucoma who has unexplained hair loss, stop topical beta-blocker treatment

The Science behind the Tip Beta adrenergic receptor blocking eye drops are often used to reduce the intraocular pressure. Because of absorption...

May 31, 2017

Neuroprotection for glaucoma: Requirements for clinical translation

Clinical paper of the month

Neuroprotection for glaucoma: Requirements for clinical translation

Author(s): Levin LA (1), Crowe ME (2), Quigley HA (3); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants 1...

May 31, 2017

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Experimental Paper of the Month

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Author(s): Zhu W (1), Jain A (2), Gramlich OW (3), Tucker BA (3), Sheffield VC (4), Kuehn MH (1) 1 Department of Ophthalmology and Visual Sciences,...

May 31, 2017

Patients with normal tension glaucoma who develop a branch retinal vein occlusion should be monitored with greater care

Tip of the month

Patients with normal tension glaucoma who develop a branch retinal vein occlusion should be monitored with greater care

The Science behind the Tip If a branch retinal vein occlusion (BRVO) occurs in a patient with normal tension glaucoma, it tends to occur in the eye...

April 30, 2017

Visual function may improve after trabeculectomy in some adults with moderately advanced glaucoma

Tip of the month

Visual function may improve after trabeculectomy in some adults with moderately advanced glaucoma

The Science behind the Tip We were taught that visual field loss from glaucoma is irreversible and that our interventions could at best, preserve...

March 31, 2017

The challenge of regenerative therapies for the optic nerve in glaucoma

Clinical paper of the month

The challenge of regenerative therapies for the optic nerve in glaucoma

Author(s): Calkins DJ (1), Pekny M (2), Cooper ML (3), Benowitz L (4); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration...

March 31, 2017

The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations

Experimental Paper of the Month

The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations

Author(s): Midgett DE (1), Pease ME (2), Jefferys JL (2), Patel M (3), Franck C (3), Quigley HA (2), Nguyen TD (4) 1 Department of Mechanical...

March 31, 2017

The regular (and sometimes clandestine) application of periocular corticosteroid cream can induce glaucoma in susceptible individuals

Tip of the month

The regular (and sometimes clandestine) application of periocular corticosteroid cream can induce glaucoma in susceptible individuals

The Science behind the Tip Steroid-induced ocular hypertension and glaucoma is typically associated with topical steroid therapy and presents with...

February 28, 2017

Posner-Schlossman Syndrome

Clinical paper of the month

Posner-Schlossman Syndrome

Author(s): Megaw R (1), Agarwal PK (2) 1 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of...

February 28, 2017

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

Experimental Paper of the Month

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

Author(s): Springelkamp H (1,2), Iglesias AI, Mishra A (3,4), Höhn R (5,6), Wojciechowski R, Khawaja AP (7), Nag A (8), Wang YX (9,10), Wang JJ...

February 28, 2017

Glaucoma Risk Alleles in the Ocular Hypertension Treatment Study

Clinical paper of the month

Glaucoma Risk Alleles in the Ocular Hypertension Treatment Study

Author(s): Scheetz TE (1), Faga B (1), Ortega L (2), Roos BR (1), Gordon MO (3), Kass MA (3), Wang K (4), Fingert JH (5) 1 Department Ophthalmology...

January 31, 2017

Lamina cribrosa in glaucoma

Experimental Paper of the Month

Lamina cribrosa in glaucoma

Author(s): Downs JC (1), Girkin CA 1 Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA....

January 31, 2017

Patients with neovascular glaucoma should be referred to a general physician as management of their underlying systemic disease should increase their life expectancy

Tip of the month

Patients with neovascular glaucoma should be referred to a general physician as management of their underlying systemic disease should increase their life expectancy

The Science behind the Tip Most patients with neovascular glaucoma have retinal ischaemia secondary to either proliferative diabetic retinopathy,...

December 31, 2016

New classes of glaucoma medications

Clinical paper of the month

New classes of glaucoma medications

Author(s): Schehlein EM (1), Novack GD, Robin AL 1 a University of Maryland School of Medicine, Department of Ophthalmology and Visual Sciences,...

December 31, 2016

The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection

Experimental Paper of the Month

The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection

Author(s): Yamamoto K (1), Sato K (1,2), Yukita M (1), Yasuda M (1), Omodaka K (1,2), Ryu M (1), Fujita K (3), Nishiguchi KM (4), Machida S (5,6),...

December 31, 2016

The risk of secondary haemorrhage after hyphaema can be reduced by using topical steroids and oral tranexamic acid

Tip of the month

The risk of secondary haemorrhage after hyphaema can be reduced by using topical steroids and oral tranexamic acid

The Science behind the Tip A hyphaema is a common and usually innocuous consequence of blunt injury or ocular surgery. However, the secondary...

November 30, 2016

Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial

Clinical paper of the month

Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial

Author(s): Azuara-Blanco A (1), Burr J (2), Ramsay C (3), Cooper D (3), Foster PJ (4), Friedman DS (5), Scotland G (6), Javanbakht M (7), Cochrane...

November 30, 2016

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine

Experimental Paper of the Month

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine

Author(s): Fini ME (1), Schwartz SG (2), Gao X (3), Jeong S (4), Patel N (5), Itakura T (6), Price MO (7), Price FW Jr (8), Varma R (9), Stamer WD...

November 30, 2016

Despite the increased central corneal thickness (CCT) that may follow lamellar corneal surgery, reliable IOP measurements can be obtained with Goldmann applanation tonometry or Pascal dynamic tomography

Tip of the month

Despite the increased central corneal thickness (CCT) that may follow lamellar corneal surgery, reliable IOP measurements can be obtained with Goldmann applanation tonometry or Pascal dynamic tomography

The Science behind the Tip Lamellar corneal surgery (DSAEK, DMEK) is replacing penetrating keratoplasty, because visual recovery is better and...

October 31, 2016

Monitoring ocular hypertension, how much and how often? A cost-effectiveness perspective

Clinical paper of the month

Monitoring ocular hypertension, how much and how often? A cost-effectiveness perspective

Author(s): Hernández R(1), Burr JM(2), Vale L(3), Azuara-Blanco A(4), Cook JA(5), Banister K(6), Tuulonen A(7), Ryan M(1); Surveillance of Ocular...

October 31, 2016

Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses

Experimental Paper of the Month

Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses

Author(s): Khawaja AP(1), Cooke Bailey JN(2), Kang JH(3), Allingham RR(4), Hauser MA(5), Brilliant M(6), Budenz DL(7), Christen WG(8), Fingert...

October 31, 2016

In patients with pigment dispersion syndrome, YAG laser peripheral iridotomy can reduce the risk of raised intraocular pressure (IOP) in some patients, but does not prevent glaucoma

Tip of the month

In patients with pigment dispersion syndrome, YAG laser peripheral iridotomy can reduce the risk of raised intraocular pressure (IOP) in some patients, but does not prevent glaucoma

The Science behind the Tip Pigment dispersion syndrome arises from posterior bowing of the iris secondary to reverse pupil block. This causes...

September 30, 2016

The Relative Odds of Progressing by Structural and Functional Tests in Glaucoma

Clinical paper of the month

The Relative Odds of Progressing by Structural and Functional Tests in Glaucoma

Author(s): Abe RY, Diniz-Filho A, Zangwill LM, Gracitelli CP, Marvasti AH, Weinreb RN, Baig S, Medeiros FA PURPOSE: The purpose of this study was...

September 30, 2016