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  • Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible...

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    Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

    Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with...

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  • Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all licensed treatments lower IOP. However, many patients...

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    Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

    Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma

Experimental Paper of the Month

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma

Author(s): Roubeix C (1,2,3), Godefroy D (4,5,6), Mias C (7), Sapienza A (8,9,10), Riancho L (11,12,13), Degardin J (14,15,16), Fradot V...

November 30, 2015

Artifacts in the SD-OCT images in a patient with glaucoma or suspected glaucoma may lead to an erroneous conclusion

Tip of the month

Artifacts in the SD-OCT images in a patient with glaucoma or suspected glaucoma may lead to an erroneous conclusion

The science behind the tip Structural measurements of the optic disc and retinal nerve fibre layer (RNFL) have become an indispensable tool in the...

October 31, 2015

Association between Platelet Function and Disc Hemorrhage in Patients with Normal Tension Glaucoma: A prospective cross-sectional study

Clinical paper of the month

Association between Platelet Function and Disc Hemorrhage in Patients with Normal Tension Glaucoma: A prospective cross-sectional study

Author(s): Shim SH (1), Kim JM (2), Woo HY (3), Shin KU (1), Koh JW (4), Park KH (5) 1 Department of Ophthalmology, Kangbuk Samsung Hospital,...

October 31, 2015

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

Experimental Paper of the Month

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

Author(s): Cueva Vargas JL (1), Osswald IK (2), Unsain N (3), Aurousseau MR (2), Barker PA (3), Bowie D (2), Di Polo A (4) 1 Department of...

October 31, 2015

The ISNT rule is of limited benefit in differentiating early glaucoma from normal

Tip of the month

The ISNT rule is of limited benefit in differentiating early glaucoma from normal

The science behind the tip The ISNT rule states that a healthy optic disc has a characteristic configuration of the neuro-retinal rim; which is...

September 30, 2015

Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up

Clinical paper of the month

Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up

Author(s): Newman-Casey PA (1), Blachley T (2), Lee PP (3), Heisler M (4), Farris KB (5), Stein JD (3) 1 Department of Ophthalmology and Visual...

September 30, 2015

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

Experimental Paper of the Month

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

Author(s): Takihara Y (1), Inatani M (2), Eto K (3), Inoue T (4), Kreymerman A (5), Miyake S (6), Ueno S (7), Nagaya M (7), Nakanishi A (7), Iwao K...

September 30, 2015

Patients with advanced glaucoma who are to undergo trabeculectomy should be warned that there is a small risk of permanent visual loss as a consequence of the surgery

Tip of the month

Patients with advanced glaucoma who are to undergo trabeculectomy should be warned that there is a small risk of permanent visual loss as a consequence of the surgery

The science behind the tip Transient visual disturbance after trabeculectomy is common and it can take several months for the vision to recover....

July 31, 2015

Relationship Between Daytime Variability of Blood Pressure or Ocular Perfusion Pressure and Glaucomatous Visual Field Progression

Clinical paper of the month

Relationship Between Daytime Variability of Blood Pressure or Ocular Perfusion Pressure and Glaucomatous Visual Field Progression

Author(s): Lee J (1), Choi J (2), Jeong D (1), Kim S (1), Kook MS (3) 1 Department of Ophthalmology, College of Medicine, University of Ulsan, Asan...

July 31, 2015

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat

Experimental Paper of the Month

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat

Author(s): Bogner B (1), Boye SL (2), Min SH (2), Peterson JJ (2), Ruan Q (2), Zhang Z (1), Reitsamer HA (1), Hauswirth WW (2), Boye SE (2) 1...

July 31, 2015

In clinical practice, anterior segment OCT cannot replace gonioscopy as a method of examining the filtration angle

Tip of the month

In clinical practice, anterior segment OCT cannot replace gonioscopy as a method of examining the filtration angle

The science behind the tip The diagnosis and management of all types of glaucoma is dependent on the accurate evaluation of the angle and its...

June 30, 2015

In every patient with ocular hypertension, search for signs of pseudoexfoliation syndrome as these patients are at significant risk of converting to glaucoma

Tip of the month

In every patient with ocular hypertension, search for signs of pseudoexfoliation syndrome as these patients are at significant risk of converting to glaucoma

The science behind the tip Patients with ocular hypertension and pseudoexfoliaton syndrome are twice as likely to convert to glaucoma as those...

June 30, 2015

Structure-Function Relationship Between Bruch's Membrane Opening-Based Optic Nerve Head Parameters and Visual Field Defects in Glaucoma

Clinical paper of the month

Structure-Function Relationship Between Bruch's Membrane Opening-Based Optic Nerve Head Parameters and Visual Field Defects in Glaucoma

Author(s): Muth DR, Hirneiß CW PURPOSE: This study was performed to evaluate the structure-function relationship between Bruch's membrane opening...

June 30, 2015

In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma

Experimental Paper of the Month

In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma

Author(s): Bosco A (1), Romero CO (2), Ambati BK (3), Vetter ML (2) 1 Department of Neurobiology & Anatomy, University of Utah;...

June 30, 2015

Primary congenital glaucoma outcomes: lessons from 23 years of follow-up

Clinical paper of the month

Primary congenital glaucoma outcomes: lessons from 23 years of follow-up

Author(s): Zagora SL(1), Funnell CL(2), Martin FJ(3), Smith JE(3), Hing S(4), Billson FA(3), Veillard AS(5), Jamieson RV(6), Grigg JR(7) 1...

May 31, 2015

Patients with progressive normal tension glaucoma may benefit from elevation of the head of the bed when they sleep

Tip of the month

Patients with progressive normal tension glaucoma may benefit from elevation of the head of the bed when they sleep

The science behind the tip Intraocular pressure (IOP) is significantly higher in the supine position than in the sitting position. Progressive...

April 30, 2015

Lamina cribrosa depth in different stages of glaucoma

Clinical paper of the month

Lamina cribrosa depth in different stages of glaucoma

Author(s): Park SC, Brumm J, Furlanetto RL, Netto C, Liu Y, Tello C, Liebmann JM, Ritch R 1 Department of Ophthalmology, Manhattan Eye, Ear and...

April 30, 2015

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Experimental Paper of the Month

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Author(s): Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS,...

April 30, 2015

RNFL measurement with SD OCT can contribute to glaucoma diagnosis, but only if prior clinical examination has yielded a relevant level of glaucoma suspicion

Tip of the month

RNFL measurement with SD OCT can contribute to glaucoma diagnosis, but only if prior clinical examination has yielded a relevant level of glaucoma suspicion

The science behind the tip It is well known that SD OCT can discriminate with reasonable accuracy between healthy volunteers and glaucoma patients...

March 31, 2015

Facts and myths of cerebrospinal fluid pressure for the physiology of the eye

Clinical paper of the month

Facts and myths of cerebrospinal fluid pressure for the physiology of the eye

Author(s): Jonas JB (1), Wang NL (2), Yang D (3), Ritch R (4), Panda-Jonas S (5) 1 Department of Ophthalmology, Medical Faculty Mannheim of the...

March 31, 2015

Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types

Experimental Paper of the Month

Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types

Author(s): El-Danaf RN (1), Huberman AD (2) 1 Department of Neurosciences, Neurobiology Section in the Division of Biological Sciences, and...

March 31, 2015

In patients with narrow filtration angles or primary angle-closure glaucoma who have a patent laser iridotomy, it is safe to prescribe any systemic drugs which have an anti-cholinergic effect on the pupil

Tip of the month

In patients with narrow filtration angles or primary angle-closure glaucoma who have a patent laser iridotomy, it is safe to prescribe any systemic drugs which have an anti-cholinergic effect on the pupil

The science behind the tip Many commonly used systemic medications have been reported to cause acute congestive angle closure in individuals with...

February 28, 2015

Long-Term Follow-up in Preperimetric Open-Angle Glaucoma: Progression Rates and Associated Factors

Clinical paper of the month

Long-Term Follow-up in Preperimetric Open-Angle Glaucoma: Progression Rates and Associated Factors

Author(s): Kim KE(1), Jeoung JW(2), Kim DM(1), Ahn SJ(3), Park KH(1), Kim SH(4) 1 Department of Ophthalmology, Seoul National University College of...

February 28, 2015

Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma

Experimental Paper of the Month

Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma

Author(s): Stankowska DL (1), Minton AZ (2), Rutledge MD (3), Mueller BH (4), Phatak NR (5), He S (6), Ma HY (7), Forster MJ (8), Yorio T (9),...

February 28, 2015

Systemic beta-blocker and nitrates result in a lowering of IOP which has implications for the management of ocular hypertension and glaucoma

Tip of the month

Systemic beta-blocker and nitrates result in a lowering of IOP which has implications for the management of ocular hypertension and glaucoma

The science behind the tip Systemic beta-blockers and nitrates are frequently used in the elderly. It has been known for many years that systemic...

January 31, 2015