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Tip: Not every peripapillary hemorrhage is a sign for glaucoma
The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are...
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The Factors Affecting the Stability of IOP Homeostasis
Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells...
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Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study
Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Association between Platelet Function and Disc Hemorrhage in Patients with Normal Tension Glaucoma: A prospective cross-sectional study
Author(s): Shim SH (1), Kim JM (2), Woo HY (3), Shin KU (1), Koh JW (4), Park KH (5) 1 Department of Ophthalmology, Kangbuk Samsung Hospital,...
October 31, 2015
Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation
Author(s): Cueva Vargas JL (1), Osswald IK (2), Unsain N (3), Aurousseau MR (2), Barker PA (3), Bowie D (2), Di Polo A (4) 1 Department of...
October 31, 2015
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The ISNT rule is of limited benefit in differentiating early glaucoma from normal
The science behind the tip The ISNT rule states that a healthy optic disc has a characteristic configuration of the neuro-retinal rim; which is...
September 30, 2015
Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up
Author(s): Newman-Casey PA (1), Blachley T (2), Lee PP (3), Heisler M (4), Farris KB (5), Stein JD (3) 1 Department of Ophthalmology and Visual...
September 30, 2015
In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS
Author(s): Takihara Y (1), Inatani M (2), Eto K (3), Inoue T (4), Kreymerman A (5), Miyake S (6), Ueno S (7), Nagaya M (7), Nakanishi A (7), Iwao K...
September 30, 2015
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Patients with advanced glaucoma who are to undergo trabeculectomy should be warned that there is a small risk of permanent visual loss as a consequence of the surgery
The science behind the tip Transient visual disturbance after trabeculectomy is common and it can take several months for the vision to recover....
July 31, 2015
Relationship Between Daytime Variability of Blood Pressure or Ocular Perfusion Pressure and Glaucomatous Visual Field Progression
Author(s): Lee J (1), Choi J (2), Jeong D (1), Kim S (1), Kook MS (3) 1 Department of Ophthalmology, College of Medicine, University of Ulsan, Asan...
July 31, 2015
Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat
Author(s): Bogner B (1), Boye SL (2), Min SH (2), Peterson JJ (2), Ruan Q (2), Zhang Z (1), Reitsamer HA (1), Hauswirth WW (2), Boye SE (2) 1...
July 31, 2015
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In clinical practice, anterior segment OCT cannot replace gonioscopy as a method of examining the filtration angle
The science behind the tip The diagnosis and management of all types of glaucoma is dependent on the accurate evaluation of the angle and its...
June 30, 2015
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In every patient with ocular hypertension, search for signs of pseudoexfoliation syndrome as these patients are at significant risk of converting to glaucoma
The science behind the tip Patients with ocular hypertension and pseudoexfoliaton syndrome are twice as likely to convert to glaucoma as those...
June 30, 2015
Structure-Function Relationship Between Bruch's Membrane Opening-Based Optic Nerve Head Parameters and Visual Field Defects in Glaucoma
Author(s): Muth DR, Hirneiß CW PURPOSE: This study was performed to evaluate the structure-function relationship between Bruch's membrane opening...
June 30, 2015
In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma
Author(s): Bosco A (1), Romero CO (2), Ambati BK (3), Vetter ML (2) 1 Department of Neurobiology & Anatomy, University of Utah;...
June 30, 2015
Primary congenital glaucoma outcomes: lessons from 23 years of follow-up
Author(s): Zagora SL(1), Funnell CL(2), Martin FJ(3), Smith JE(3), Hing S(4), Billson FA(3), Veillard AS(5), Jamieson RV(6), Grigg JR(7) 1...
May 31, 2015
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Patients with progressive normal tension glaucoma may benefit from elevation of the head of the bed when they sleep
The science behind the tip Intraocular pressure (IOP) is significantly higher in the supine position than in the sitting position. Progressive...
April 30, 2015
Lamina cribrosa depth in different stages of glaucoma
Author(s): Park SC, Brumm J, Furlanetto RL, Netto C, Liu Y, Tello C, Liebmann JM, Ritch R 1 Department of Ophthalmology, Manhattan Eye, Ear and...
April 30, 2015
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome
Author(s): Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS,...
April 30, 2015
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RNFL measurement with SD OCT can contribute to glaucoma diagnosis, but only if prior clinical examination has yielded a relevant level of glaucoma suspicion
The science behind the tip It is well known that SD OCT can discriminate with reasonable accuracy between healthy volunteers and glaucoma patients...
March 31, 2015
Facts and myths of cerebrospinal fluid pressure for the physiology of the eye
Author(s): Jonas JB (1), Wang NL (2), Yang D (3), Ritch R (4), Panda-Jonas S (5) 1 Department of Ophthalmology, Medical Faculty Mannheim of the...
March 31, 2015
Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
Author(s): El-Danaf RN (1), Huberman AD (2) 1 Department of Neurosciences, Neurobiology Section in the Division of Biological Sciences, and...
March 31, 2015
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In patients with narrow filtration angles or primary angle-closure glaucoma who have a patent laser iridotomy, it is safe to prescribe any systemic drugs which have an anti-cholinergic effect on the pupil
The science behind the tip Many commonly used systemic medications have been reported to cause acute congestive angle closure in individuals with...
February 28, 2015
Long-Term Follow-up in Preperimetric Open-Angle Glaucoma: Progression Rates and Associated Factors
Author(s): Kim KE(1), Jeoung JW(2), Kim DM(1), Ahn SJ(3), Park KH(1), Kim SH(4) 1 Department of Ophthalmology, Seoul National University College of...
February 28, 2015
Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma
Author(s): Stankowska DL (1), Minton AZ (2), Rutledge MD (3), Mueller BH (4), Phatak NR (5), He S (6), Ma HY (7), Forster MJ (8), Yorio T (9),...
February 28, 2015
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Systemic beta-blocker and nitrates result in a lowering of IOP which has implications for the management of ocular hypertension and glaucoma
The science behind the tip Systemic beta-blockers and nitrates are frequently used in the elderly. It has been known for many years that systemic...
January 31, 2015
The impact of lack of government insured routine eye examinations on the incidence of self-reported glaucoma, cataracts and vision loss
Author(s): Chan CH (1), Trope GE (2), Badley EM (3), Buys Y (4), Jin YP (5) 1 Division of Health Care and Outcomes Research, Toronto Western...
January 31, 2015
Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma
Author(s): Wu J (1), Zhang S (1), Nickerson JM (2), Gao F (3), Sun Z (4), Chen X (3), Zhang S (3), Zhang R (3), Gao F (3), Chen J (3), Luo Y (3),...
January 31, 2015