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Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life
The Science behind the Tip In contrast to underdiagnosis, which has been described in...
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Peripapillary Retinoschisis in Glaucoma: A Systematic Review
PURPOSE: The frequent use of optical coherence tomography increased the detection of...
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Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Purpose: To determine whether primary trabeculectomy or medical treatment produces better...
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Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension
Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Clinical classification of childhood glaucomas
Author(s): Yeung HH, Walton DS Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA....
July 31, 2010
Mitochondrial damage in the trabecular meshwork of patients with glaucoma
Author(s): Izzotti A, Saccà SC, Longobardi M, Cartiglia C. Department of Health Sciences, University of Genoa, Genoa, Italy. izzotti@unige.it...
July 31, 2010
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In patients with chronic angle-closure glaucoma and cataract, phacoemulsification with IOL implantation usually results in IOP control up to 2 years after surgery
The Science behind the Tip An anteriorly positioned and thickened lens plays an important role in the pathogenesis of anterior chamber shallowing...
June 30, 2010
Effect of patient's life expectancy on the cost-effectiveness of treatment for ocular hypertension
Author(s): Kymes SM, Plotzke MR, Kass MA, Boland MV, Gordon MO OBJECTIVE: To assess the influence of expected life span on the cost-effectiveness...
June 30, 2010
Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration
Author(s): Baltan S, Inman DM, Danilov CA, Morrison RS, Calkins DJ, Horner PJ. We tested the hypothesis that glaucoma disrupts electrophysiological...
June 30, 2010
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Measurement of central corneal thickness is essential to ensure optimal management of glaucoma patients
The Science behind the Tip The measurement of central corneal thickness (CCT) has emerged as an important parameter to determine in all patients...
May 31, 2010
Delaying Treatment of Ocular Hypertension: the Ocular Hypertension Treatment Study
Author(s): Michael A. Kass, MD; Mae O. Gordon, PhD; Feng Gao, PhD; Dale K. Heuer, MD; Eve J. Higginbotham, MD; Chris A. Johnson, PhD; John K....
May 31, 2010
Neuroprotective Effects of Intravitreal Mesenchymal Stem Cell Transplantation in Experimental Glaucoma
Author(s): Thomas V. Johnson(1,2,3) Natalie D. Bull(1,2) David P. Hunt(1), Nephtali Marina(1), Stanislav I. Tomarev(3), Keith R. Martin(1) Centre...
May 31, 2010
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Disc Haemorrhages
The Science behind the Tip Although described most commonly in normal tension glaucoma, optic disc haemorrhages may occur in all forms of glaucoma....
April 30, 2010
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When should neuroradiological imaging be undertaken in patients with normal tension glaucoma?
The Science behind the Tip Clinicians must remain vigilant to detect intracranial pathology in patients with normal tension glaucoma. Most patients...
March 31, 2010
Simvastatin and Disease Stabilization in Normal Tension Glaucoma: A Cohort Study.
Author(s): Leung DY, Li FC, Kwong YY, Tham CC, Chi SC, Lam DS. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong...
March 31, 2010
Episcleral Venous Pressure Responses to Topical Nitroprusside and N-Nitro-L-arginine Methyl Ester.
Author(s): Zamora DO, Kiel JW. Department of Ophthalmology, University of Texas Health Science Center, San Antonio, Texas. PURPOSE: To determine...
March 31, 2010
Cerebrospinal Fluid Pressure in Glaucoma A Prospective Study.
Author(s): Ren R, Jonas JB, Tian G, Zhen Y, Ma K, Li S, Wang H, Li B, Zhang X, Wang N Beijing Institute of Ophthalmology, Beijing Tongren Eye...
February 28, 2010
Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation.
Author(s): Tezel G, Yang X, Luo C, Cai J, Kain AD, Powell DW, Kuehn MH, Pierce WM Department of Ophthalmology and Visual Sciences, University of...
February 28, 2010
Prediction of glaucomatous visual field loss by extrapolation of linear trends
Author(s): Bengtsson B, Patella VM, Heijl A Departments of Clinical Sciences and Ophthalmology, Lund University, Malmö University Hospital,...
January 31, 2010
Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration
Author(s): Salinas-Navarro M, Alarcón-Martínez L, Valiente-Soriano FJ, Jiménez-López M, Mayor-Torroglosa S, Avilés-Trigueros M, Villegas-Pérez MP,...
January 31, 2010
Increased likelihood of glaucoma at the same screening intraocular pressure in subjects with pseudoexfoliation: the Thessaloniki Eye Study
Author(s): Topouzis F, Harris A, Wilson MR, Koskosas A, Founti P, Yu F, Anastasopoulos E, Pappas T, Coleman AL Department of Ophthalmology, School...
November 30, 2009
Complex antibody profile changes in an experimental autoimmune glaucoma animal model
Author(s): Joachim SC, Grus FH, Kraft D, White-Farrar K, Barnes G, Barbeck M, Ghanaati S, Cao S, Li B, Wax MB Experimental Ophthalmology,...
October 31, 2009
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Glaucoma medications may harm the foetus and neonate
The Science behind the Tip Human data on adverse effects of glaucoma medications during pregnancy and lactation are sparse because the coincidence...
May 31, 2009
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Intraocular pressure is overestimated in eyes with a thick cornea
The Science behind the Tip Variability in central corneal thickness (CCT) is a potent confounder of Goldmann applanation tonometry (GAT)(1). The...
April 30, 2009
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A thin cornea is a risk factor for primary open-angle glaucoma
The Science behind the Tip Central corneal thickness (CCT) varies among individuals, the average CCT in the general population being approximately...
March 31, 2009
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Intraocular pressure is underestimated in eyes with a thin cornea
The Science behind the Tip Variability in central corneal thickness (CCT) is a potent confounder of applanation tonometry techniques such as...
February 28, 2009
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Visual field defects are filled-in by the brain
The Science behind the Tip Contrary to long held beliefs, cortical maps in the brain are not rigid. Extensive reorganization (i.e. brain remapping)...
January 31, 2009
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Pseudoexfoliation glaucoma has a strong genetic component
Publishing date: December 2008 The Science behind the Tip Pseudoexfoliation or exfoliation syndrome (PEX) is the most common identifiable condition...
December 31, 2008
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Chase the family of primary-open angle glaucoma patients
The Science behind the Tip Various modes of screening for primary open-angle glaucoma (POAG), i.e. different combinations of tonometry and...
November 30, 2008