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  • Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

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    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate...

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  • A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

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    A foundation model for generalizable disease detection from retinal images

    A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health...

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  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

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    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation...

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  • Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

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    Beware of acute corneal oedema after SLT in selected patients

    Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT)...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Rapamycin Removes Damaged Mitochondria and Protects Human Trabecular Meshwork (TM-1) Cells from Chronic Oxidative Stress

Experimental Paper of the Month

Rapamycin Removes Damaged Mitochondria and Protects Human Trabecular Meshwork (TM-1) Cells from Chronic Oxidative Stress

Author(s): He JN (1,2), Zhang SD (3), Qu Y (2), Wang HL (2), Tham CC (1), Pang CP (1), Chu WK (4) 1 Department of Ophthalmology and Visual...

May 31, 2019

Border Tissue Morphology is Spatially Associated with Focal Lamina Cribrosa Defect and Deep-Layer Microvasculature Dropout in Open-Angle Glaucoma

Experimental Paper of the Month

Border Tissue Morphology is Spatially Associated with Focal Lamina Cribrosa Defect and Deep-Layer Microvasculature Dropout in Open-Angle Glaucoma

Author(s): Han JC (1), Choi JH (1), Park DY (1), Lee EJ (1), Kee C (2) 1 Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan...

April 30, 2019

Artificial intelligence and deep learning in ophthalmology

Experimental Paper of the Month

Artificial intelligence and deep learning in ophthalmology

Author(s): Ting DSW (1), Pasquale LR (2), Peng L (3), Campbell JP (4), Lee AY (5), Raman R (6), Tan GSW (7), Schmetterer L (7,8,9,10), Keane PA...

March 31, 2019

Identification of Candidate miRNA Biomarkers for Glaucoma

Experimental Paper of the Month

Identification of Candidate miRNA Biomarkers for Glaucoma

Author(s): Hindle AG1, Thoonen R2, Jasien JV (3), Grange RMH (1), Amin K (4), Wise J (4), Ozaki M (5), Ritch R (3), Malhotra R (2), Buys ES (1) 1...

February 28, 2019

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Experimental Paper of the Month

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Author(s): Mathieu E (1,2,3), Gupta N (1,2,3,4,5), Paczka-Giorgi LA (1,2), Zhou X (1,2), Ahari A (1,2), Lani R (1), Hanna J (1,2,3), Yücel YH...

January 31, 2019

Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review

Experimental Paper of the Month

Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review

Author(s): Sabel BA (1), Flammer J (2), Merabet LB (3) 1 Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University of...

December 31, 2018

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Experimental Paper of the Month

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Author(s): Singh LN (1), Crowston JG (2), Lopez Sanchez MIG (2), Van Bergen NJ (2), Kearns LS (2), Hewitt AW (2,3), Yazar S (4,5), Mackey DA (4),...

November 30, 2018

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

Experimental Paper of the Month

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

Author(s): Bosco A(1), Anderson SR(2), Breen KT(2), Romero CO(2), Steele MR(2), Chiodo VA(3), Boye SL(3), Hauswirth WW(3), Tomlinson S(4), Vetter...

October 31, 2018

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

Experimental Paper of the Month

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

Author(s): MacGregor S (1), Ong JS (2), An J (2), Han X (2), Zhou T (3), Siggs OM (3), Law MH (2), Souzeau E (3), Sharma S (3), Lynn DJ (4,5,6),...

September 30, 2018

Nogo-A inactivation improves visual plasticity and recovery after retinal injury

Experimental Paper of the Month

Nogo-A inactivation improves visual plasticity and recovery after retinal injury

Author(s): Mdzomba JB (1), Jordi N (2), Rodriguez L (1), Joly S (1), Bretzner F (3), Pernet V (4) 1 CUO-Recherche, Centre de recherche du CHU de...

July 31, 2018

Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects

Experimental Paper of the Month

Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects

Author(s): Chitranshi N (1), Dheer Y (1), Abbasi M (1), You Y (2), Graham SL (1), Gupta V (1) 1 Faculty of Medicine and Health Sciences, Macquarie...

June 30, 2018

The coma in glaucoma: Retinal ganglion cell dysfunction and recovery

Experimental Paper of the Month

The coma in glaucoma: Retinal ganglion cell dysfunction and recovery

Author(s): Fry LE (1), Fahy E (2), Chrysostomou V (3), Hui F (2), Tang J (2), van Wijngaarden P (2), Petrou S (4), Crowston JG (5) 1 Centre for Eye...

May 31, 2018

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma

Experimental Paper of the Month

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma

Author(s): Huard DJE (1), Crowley VM (2), Du Y (3), Cordova RA (4), Sun Z (4), Tomlin MO (1), Dickey CA (4), Koren J 3rd (4), Blair L (4), Fu H...

April 30, 2018

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Experimental Paper of the Month

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Author(s): Gharahkhani P (1), Burdon KP (2), Cooke Bailey JN (3), Hewitt AW (2), Law MH (4), Pasquale LR (5), (6), Kang JH (6), Haines JL (3),...

March 31, 2018

Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma

Experimental Paper of the Month

Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma

Author(s): Chou TH (1), Musada GR (2), Romano GL (3), Bolton E (4), Porciatti V (5) 1 Bascom Palmer Eye Institute, University of Miami Miller...

February 28, 2018

ASK1 in neurodegeneration

Experimental Paper of the Month

ASK1 in neurodegeneration

Author(s): Guo X (1), Namekata K (2), Kimura A (2), Harada C (2), Harada T (2) 1 Visual Research Project, Tokyo Metropolitan Institute of Medical...

January 31, 2018

Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA

Experimental Paper of the Month

Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA

Author(s): Takahama S (1), Adetunji MO (1), Zhao T (2), Chen S2, Li W (2), Tomarev SI (1) 1 Section on Retinal Ganglion Cell Biology, Laboratory of...

November 30, 2017

Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG)

Experimental Paper of the Month

Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG)

Author(s): Schmelter C (1), Perumal N (1), Funke S (1), Bell K (1), Pfeiffer N (1), Grus FH (1) 1 Department of Experimental and Translational...

October 31, 2017

Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes

Experimental Paper of the Month

Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes

Author(s): Van Houcke J (1), Bollaerts I (1), Geeraerts E (1), Davis B (2), Beckers A (1), Van Hove I (1), Lemmens K (1), De Groef L (3), Moons L...

October 31, 2017

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Experimental Paper of the Month

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...

September 30, 2017

Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss

Experimental Paper of the Month

Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss

Author(s): 1 Neuroscience Graduate Program, Vanderbilt UniversityNashville, TN, United States. 2 Department of Ophthalmology and Visual Sciences,...

July 31, 2017

Regulation of intraocular pressure by microRNA cluster miR-143/145

Experimental Paper of the Month

Regulation of intraocular pressure by microRNA cluster miR-143/145

Author(s): Li X (1,2), Zhao F (3,4), Xin M (5), Li G (6), Luna C (6), Li G (1), Zhou Q (4), He Y (2), Yu B (4), Olson E (7), Gonzalez P (6), Wang S...

June 30, 2017

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Experimental Paper of the Month

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Author(s): Zhu W (1), Jain A (2), Gramlich OW (3), Tucker BA (3), Sheffield VC (4), Kuehn MH (1) 1 Department of Ophthalmology and Visual Sciences,...

May 31, 2017

The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations

Experimental Paper of the Month

The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations

Author(s): Midgett DE (1), Pease ME (2), Jefferys JL (2), Patel M (3), Franck C (3), Quigley HA (2), Nguyen TD (4) 1 Department of Mechanical...

March 31, 2017

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

Experimental Paper of the Month

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

Author(s): Springelkamp H (1,2), Iglesias AI, Mishra A (3,4), Höhn R (5,6), Wojciechowski R, Khawaja AP (7), Nag A (8), Wang YX (9,10), Wang JJ...

February 28, 2017