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  • Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

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    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate...

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  • A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

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    A foundation model for generalizable disease detection from retinal images

    A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health...

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  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

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    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation...

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  • Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

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    Beware of acute corneal oedema after SLT in selected patients

    Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT)...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

    Learn more...
  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Artemin augments survival and axon regeneration in axotomized retinal ganglion cells

Experimental Paper of the Month

Artemin augments survival and axon regeneration in axotomized retinal ganglion cells

Author(s): Omodaka K(1), Kurimoto T, Nakamura O, Sato K, Yasuda M, Tanaka Y, Himori N, Yokoyama Y, Nakazawa T 1 Department of Ophthalmology and...

September 30, 2014

Optic Nerve Head Blood Flow Response to Reduced Ocular Perfusion Pressure by Alteration of Either the Blood Pressure or Intraocular Pressure

Experimental Paper of the Month

Optic Nerve Head Blood Flow Response to Reduced Ocular Perfusion Pressure by Alteration of Either the Blood Pressure or Intraocular Pressure

Author(s): Wang L(1), Cull GA, Fortune B. 1 Devers Eye Institute, Legacy Research Institute, Portland, OR, USA. ABSTRACT PURPOSE: To test the...

July 31, 2014

Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

Experimental Paper of the Month

Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

Author(s): Ulmer Carnes M(1), Liu YP(2), Allingham RR(3), Whigham BT(3), Havens S(3), Garrett ME(1), Qiao C(4); NEIGHBORHOOD Consortium...

June 30, 2014

MMPs in the neuroretina and optic nerve: modulators of glaucoma pathogenesis and repair?

Experimental Paper of the Month

MMPs in the neuroretina and optic nerve: modulators of glaucoma pathogenesis and repair?

Author(s): De Groef L(1), Van Hove I, Dekeyster E, Stalmans I, Moons L. 1 Laboratory of Neural Circuit Development and Regeneration, Animal...

May 31, 2014

γ-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway

Experimental Paper of the Month

γ-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway

Author(s): Wilding C, Bell K, Beck S, Funke S, Pfeiffer N, Grus FH. Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the...

April 30, 2014

Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing

Experimental Paper of the Month

Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing

Author(s): Jeoung JW(1), Seong MW, Park SS, Kim DM, Kim SH, Park KH. 1 Department of Ophthalmology, Seoul National University Hospital, Seoul,...

March 31, 2014

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Experimental Paper of the Month

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Author(s): Santos-Carvalho A (1), Alvaro AR (2), Martins J (3), Ambrósio AF (4), Cavadas C (5) Neuropeptide Y (NPY) and NPY receptors are widely...

February 28, 2014

Regulation of Plasticity and Fibrogenic Activity of Trabecular Meshwork Cells by Rho GTPase Signaling

Experimental Paper of the Month

Regulation of Plasticity and Fibrogenic Activity of Trabecular Meshwork Cells by Rho GTPase Signaling

Author(s): Pattabiraman PP, Maddala R, Rao PV. Department of Ophthalmology, Duke University School of Medicine, Durham, NC, 27710. Glaucoma, a...

January 31, 2014

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix production in Trabecular Meshwork and Lamina Cribrosa cells

Experimental Paper of the Month

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix production in Trabecular Meshwork and Lamina Cribrosa cells

Author(s): Wallace DM, Clark AF, Lipson K, Andrews D, Crean J, O'Brien CJ. PURPOSE: We have previously demonstrated elevated levels of Connective...

December 31, 2013

Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome

Experimental Paper of the Month

Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome

Author(s): Johnson TV, Dekorver NW, Levasseur VA, Osborne A, Tassoni A, Lorber B, Heller JP, Villasmil R, Bull ND, Martin KR, Tomarev SI 1 Section...

November 30, 2013

Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmuneglaucoma

Experimental Paper of the Month

Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmuneglaucoma

Author(s): Joachim SC, Reinehr S, Kuehn S, Laspas P, Gramlich OW, Kuehn M, Tischoff I, von Pein HD, Dick HB, Grus FH Experimental Eye Research...

October 31, 2013

Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier than RNFL Thickness Changes in Experimental Glaucoma

Experimental Paper of the Month

Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier than RNFL Thickness Changes in Experimental Glaucoma

Author(s): Fortune B, Burgoyne CF, Cull G, Reynaud J, Wang L. Devers Eye Institute, Legacy Research Institute, 1225 NE 2nd Avenue, 3rd Floor,...

September 30, 2013

Ocular Rigidity, Outflow facility, Ocular Pulse Amplitude and Pulsatile Ocular Blood Flow in Open AngleGlaucoma; a manometric study

Experimental Paper of the Month

Ocular Rigidity, Outflow facility, Ocular Pulse Amplitude and Pulsatile Ocular Blood Flow in Open AngleGlaucoma; a manometric study

Author(s): Dastiridou AI, Tsironi EE, Tsilimbaris M, Ginis H, Karyotakis N, Cholevas P, Androudi S, Pallikaris IG. Ophthalmology Department,...

July 31, 2013

Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma

Experimental Paper of the Month

Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma

Author(s): Almasieh M, Macintyre JN, Pouliot M, Casanova C, Vaucher E, Kelly ME, Di Polo A. Department of Pathology and Cell Biology and Groupe de...

June 30, 2013

Reduction in Blood Glutathione Levels Occurs Similarly in Patients with Primary-Open Angle or Normal Tension Glaucoma

Experimental Paper of the Month

Reduction in Blood Glutathione Levels Occurs Similarly in Patients with Primary-Open Angle or Normal Tension Glaucoma

Author(s): Gherghel D, Mroczkowska S, Qin L Vascular Research Laboratory, Ophthalmic Research Group, Aston University, School of Life and Health...

May 31, 2013

Tissue engineering the retinal ganglion cell nerve fiber layer

Experimental Paper of the Month

Tissue engineering the retinal ganglion cell nerve fiber layer

Author(s): Kador KE, Montero RB, Venugopalan P, Hertz J, Zindell AN, Valenzuela DA, Uddin MS, Lavik EB, Muller KJ, Andreopoulos FM, Goldberg JL...

April 30, 2013

Discovery of novel human aquaporin-1 blockers

Experimental Paper of the Month

Discovery of novel human aquaporin-1 blockers

Author(s): Seeliger D, Zapater C, Krenc D, Haddoub R, Flitsch S, Beitz E, Cerdà J, de Groot BL. Human aquaporin-1 (hAQP1) is a water channel found...

March 31, 2013

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cell line

Experimental Paper of the Month

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cell line

Author(s): Koriyama Y, Nakayama Y, Matsugo S, Kato S. Department of Molecular Neurobiology, Graduate School of Medicine. Electronic address:...

February 28, 2013

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits

Experimental Paper of the Month

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits

Author(s): Brignole-Baudouin F, Desbenoit N, Hamm G, Liang H, Both JP, Brunelle A, Fournier I, Guerineau V, Legouffe R, Stauber J, Touboul D,...

January 31, 2013

Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient

Experimental Paper of the Month

Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient

Author(s): Samuels BC, Hammes NM, Johnson PL, Shekhar A, McKinnon SJ, Allingham RR Eugene and Marilyn Glick Eye Institute, the. PURPOSE:...

December 31, 2012

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Experimental Paper of the Month

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Author(s): Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu L,...

November 30, 2012

Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma

Experimental Paper of the Month

Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma

Author(s): Gardiner SK, Fortune B, Wang L, Downs JC, Burgoyne CF Devers Eye Institute, Legacy Health, 1225 NE 2nd Ave., Portland, OR 97232, USA....

October 31, 2012

siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice

Experimental Paper of the Month

siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice

Author(s): Liu Q, Wu K, Qiu X, Yang Y, Lin X, Yu M Few reports described efficient transfection in the trabecular meshwork (TM) in vivo. In the...

September 30, 2012

Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma

Experimental Paper of the Month

Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma

Author(s): Fortune B, Burgoyne CF, Cull GA, Reynaud J, Wang L. Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research...

July 31, 2012

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

Experimental Paper of the Month

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

Author(s): Gallego BI, Salazar JJ, de Hoz R, Rojas B, Ramírez AI, Salinas-Navarro M, Ortín-Martínez A, Valiente-Soriano FJ, Avilés-Trigueros M,...

June 30, 2012