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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the pathogenesis of primary open-angle glaucoma (POAG), the...
November 12, 2024
IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space
Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to reduce intraocular pressure (IOP) in rabbits as a...
October 15, 2024
Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension
Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway undeniably plays a pivotal role in the pathophysiology...
September 12, 2024
Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition
Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible...
July 11, 2024
The Factors Affecting the Stability of IOP Homeostasis
Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells provides a fast, IOP-sensitive feedback signal that...
June 16, 2024
TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage
Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...
May 15, 2024
Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how...
April 15, 2024
A foundation model for generalizable disease detection from retinal images
Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...
March 14, 2024
Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway
Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide....
February 12, 2024
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...
January 15, 2024
Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering
Significance The “in silico–in vitro–in vivo” funnel holds significant potential for identifying targets to control cellular processes in research...
December 17, 2023
How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2Ophthalmic Engineering & Innovation Laboratory, Singapore Eye...
November 15, 2023
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
Author(s): Xikun Han 1,2,37 , Puya Gharahkhani 1,2,3,37, Andrew R. Hamel 4,5, Jue Sheng Ong 1, Miguel E. Rentería 2,3,6, Puja Mehta 4,5, Xianjun...
October 15, 2023
Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer
Author(s): Ronen E Mukamel (1), Robert E Handsaker (2), Maxwell A Sherman (3), Alison R Barton (4), Margaux L A Hujoel (5), Steven A McCarroll (6),...
September 15, 2023
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...
July 30, 2023
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Ligand-induced activation and G protein coupling of prostaglandin F2α receptor
Author(s): Canrong Wu (1), Youwei Xu (2), Qian He (2), Dianrong Li (3), Jia Duan (2), Changyao Li (4,5), Chongzhao You (2), Han Chen (6), Weiliang...
June 30, 2023
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Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia
Author(s): Mahmoud T KhalafAllah (1,2), Preston A Fuchs (3), Fred Nugen (3), Mustapha El Hamdaoui (3), Alexander Levy (4), David T Redden (5),...
May 31, 2023
Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma
Author(s): Jae H Kang (1), Oana Zeleznik (1), Lisa Frueh (1), Jessica Lasky-Su (1), A Heather Eliassen (1,2), Clary Clish (3), Bernard A Rosner...
April 01, 2023
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Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant
Author(s): W Daniel Stamer (1), Kristin M Perkumas (1), Min H Kang (2), Mohammed Dibas (3), Michael R Robinson (3), Douglas J Rhee (2) 1 Department...
March 31, 2023
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Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway
Author(s): Yunsheng Qiao (1), Zhongmou Sun (2), Chen Tan (1), Junyi Lai (1), Xinghuai Sun (1,3,4), Junyi Chen (1,3,4) 1 Department of Ophthalmology...
February 28, 2023
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Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance
Author(s): Emmi Kapiainen (1,2,3), Harri Elamaa (1,2,3), Ilkka Miinalainen (2,3), Valerio Izzi (1,2,4,5), Lauri Eklund (1,2,3) 1 Oulu Center for...
January 31, 2023
Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma
Author(s): Haojie Fu (1,2), Owen M Siggs (3,4), Lachlan Sw Knight (3), Sandra E Staffieri (5,6,7), Jonathan B Ruddle (7), Amy E Birsner (1), Edward...
December 29, 2022
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Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues
Author(s): Alireza Karimi (1), Reza Razaghi (1), Seyed Mohammadali Rahmati (2), Christopher A Girkin (1), J Crawford Downs (1) 1 Department of...
November 30, 2022
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METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma
Author(s): Yang Pan (1), Akiko Suga (1), Itaru Kimura (2), Chojiro Kimura (3), Yuriko Minegishi (1), Mao Nakayama (1), Kazutoshi Yoshitake (1),...
October 31, 2022
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Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes
Author(s): Liang Li (1), Fang Fang (2), Xue Feng (1), Pei Zhuang (1), Haoliang Huang (1), Pingting Liu (1), Liang Liu (1), Adam Z Xu (3), Lei S Qi...
September 30, 2022