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  • Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

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    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate...

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  • A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

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    A foundation model for generalizable disease detection from retinal images

    A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health...

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  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

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    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation...

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  • Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

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    Beware of acute corneal oedema after SLT in selected patients

    Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT)...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies

Experimental Paper of the Month

Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies

Author(s): Benjamin R Thomson (1,2), Pan Liu (1,2), Tuncer Onay (1), Jing Du (1,2), Stuart W Tompson (3), Sol Misener (1,2), Raj R Purohit (1,2),...

December 31, 2021

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Experimental Paper of the Month

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Author(s): K Saidas Nair (# 1), Chitrangda Srivastava (# 2), Robert V Brown (# 2), Swanand Koli (3), Hélène Choquet (4), Hong Soon Kang (2),...

November 30, 2021

Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

Experimental Paper of the Month

Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

Author(s): 1 Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 2 Department of Neuroscience, Yale...

October 31, 2021

Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury

Experimental Paper of the Month

Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury

Author(s): Ling-Ping Cen (1), Tsz Kin Ng (1,2,3), Jia-Jian Liang (1), Ciyan Xu (1), Xi Zhuang (1), Yu-Fen Liu (1,2), Shao-Lang Chen (1), Yanxuan Xu...

September 30, 2021

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Experimental Paper of the Month

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Author(s): Guorong Li (1), Astrid F Nottebaum (2), Mitchell Brigell (3), Iris D Navarro (1), Ute Ipe (2), Sarthak Mishra (2), Maria Gomez-Caraballo...

July 31, 2021

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Experimental Paper of the Month

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Author(s): Pinkal D Patel (1), Yen-Lin Chen (2), Ramesh B Kasetti (1), Prabhavathi Maddineni (1), William Mayhew (1), J Cameron Millar (1), Dorette...

June 30, 2021

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Experimental Paper of the Month

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Author(s): Puya Gharahkhani (1), Eric Jorgenson (2), Pirro Hysi (3), Anthony P Khawaja (4,5), Sarah Pendergrass (6) et al. 1 QIMR Berghofer Medical...

May 31, 2021

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Experimental Paper of the Month

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Author(s): Genetics of Exfoliation Syndrome Partnership For a full list of authors and affiliations please visit...

April 30, 2021

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Experimental Paper of the Month

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Author(s): Veselina Petrova (1), Craig S Pearson (2), Jared Ching (3,4,5), James R Tribble (6), Andrea G Solano (2), Yunfei Yang (5), Fiona M Love...

March 31, 2021

Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

Experimental Paper of the Month

Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

Author(s): Fengbin Lin (1), Fei Li (1), Kai Gao (1), Wanbing He (1), Jun Zeng (1), Yu Chen (1), Meiling Chen (1), Weijing Cheng (1), Yunhe Song...

February 28, 2021

Peripapillary sclera exhibits a v-shaped configuration that is more pronounced in glaucoma eyes

Experimental Paper of the Month

Peripapillary sclera exhibits a v-shaped configuration that is more pronounced in glaucoma eyes

Author(s): Xiaofei Wang (1), Tin A Tun (2,3), Monisha Esther Nongpiur (3,4), Hla M Htoon (3), Yih Chung Tham (3), Nicholas G Strouthidis (5,6), Tin...

January 31, 2021

Metabolomic profiling of aqueous humor from glaucoma patients - The metabolomics in surgical ophthalmological patients (MISO) study

Experimental Paper of the Month

Metabolomic profiling of aqueous humor from glaucoma patients - The metabolomics in surgical ophthalmological patients (MISO) study

Author(s): João Barbosa Breda (1), Anca Croitor Sava (2), Uwe Himmelreich (2), Alix Somers (3), Christophe Matthys (4), Amândio Rocha Sousa (5),...

December 31, 2020

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases

Experimental Paper of the Month

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases

Author(s): Bryn L Brazile (1), Bin Yang (1,2), Susannah Waxman (1) , Po Lam (1), Andrew P Voorhees (1), Yi Hua (1), Ralitsa T Loewen (1), Nils A...

October 31, 2020

Association of Glaucoma Risk Genes with Retinal Nerve Fiber Layer in a Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study

Experimental Paper of the Month

Association of Glaucoma Risk Genes with Retinal Nerve Fiber Layer in a Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study

Author(s): Xiaoran Chai (1,2,3), Kok Yao Low (1,4), Yih Chung Tham (1), Miao Li Chee (1), Sahil Thakur (1), Liang Zhang (1), Nicholas Y Tan (1),...

September 30, 2020

Efficacy for Differentiating Nonglaucomatous Versus Glaucomatous Optic Neuropathy Using Deep Learning Systems

Experimental Paper of the Month

Efficacy for Differentiating Nonglaucomatous Versus Glaucomatous Optic Neuropathy Using Deep Learning Systems

Author(s): Hee Kyung Yang (1), Young Jae Kim (2), Jae Yun Sung (1), Dong Hyun Kim (1), Kwang Gi Kim (3), Jeong-Min Hwang (4) 1 Department of...

July 31, 2020

Using Deep Learning to Automate Goldmann Applanation Tonometry Readings

Experimental Paper of the Month

Using Deep Learning to Automate Goldmann Applanation Tonometry Readings

Author(s): Ted Spaide (1), Yue Wu (1), Ryan T Yanagihara (1), Shu Feng (1), Omar Ghabra (1), Jonathan S Yi (1), Philip P Chen (1), Francy Moses...

June 30, 2020

Circadian Regulation of IOP Rhythm by Dual Pathways of Glucocorticoids and the Sympathetic Nervous System

Experimental Paper of the Month

Circadian Regulation of IOP Rhythm by Dual Pathways of Glucocorticoids and the Sympathetic Nervous System

Author(s): Ikegami K, Shigeyoshi Y, Masubuchi S PURPOSE: Elevated IOP can cause the development of glaucoma. The circadian rhythm of IOP depends on...

May 31, 2020

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry

Experimental Paper of the Month

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry

Author(s): Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser MA (1,2,3,4), Allingham RR (2,3,4), Aung T (3,4,5,6), Van...

March 31, 2020

Electrophysiology in Glaucoma

Experimental Paper of the Month

Electrophysiology in Glaucoma

Author(s): Senger C (1), Moreto R (1), Watanabe SES ()2, Matos AG (1), Paula JS (1) 1 Department of Ophthalmology, Otorhinolaryngology and Head and...

February 29, 2020

Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma

Experimental Paper of the Month

Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma

Author(s): Fischer RA (1), Risner ML (2,3), Roux AL (2), Wareham LK (2), Sappington RM (1,2,3) 1 Department of Pharmacology, Vanderbilt University,...

December 31, 2019

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Experimental Paper of the Month

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Author(s): Khatib TZ (1,2,3), Martin KR (1,2,4,5,6,7) 1 John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of...

November 30, 2019

Cholinergic nervous system and glaucoma: From basic science to clinical applications

Experimental Paper of the Month

Cholinergic nervous system and glaucoma: From basic science to clinical applications

Author(s): Faiq MA (1), Wollstein G (1), Schuman JS (1), Chan KC (2) 1 Department of Ophthalmology, New York University (NYU) School of Medicine,...

October 31, 2019

microRNA dysregulation in neurodegenerative diseases: A systematic review

Experimental Paper of the Month

microRNA dysregulation in neurodegenerative diseases: A systematic review

Author(s): Juźwik CA (1), Sage-Drake S (2), Zhang Y (3), Paradis-Isler N (4), Sylvester A (5), Amar-Zifkin A (6), Douglas C (7), Morquette B (8),...

September 30, 2019

Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma

Experimental Paper of the Month

Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma

Author(s): Pérez de Lara MJ (1), Avilés-Trigueros M (2), Guzmán-Aránguez A (1), Valiente-Soriano FJ (2), de la Villa P (3), Vidal-Sanz M (4),...

July 31, 2019

Impact of Posterior Sclera on Glaucoma Progression in Treated Myopic Normal-Tension Glaucoma Using Reconstructed Optical Coherence Tomographic Images

Experimental Paper of the Month

Impact of Posterior Sclera on Glaucoma Progression in Treated Myopic Normal-Tension Glaucoma Using Reconstructed Optical Coherence Tomographic Images

Author(s): Kim YC (1), Koo YH (2), Jung KI (3), Park CK (3) 1 Department of Ophthalmology, College of Medicine, Incheon St. Mary's Hospital, The...

June 30, 2019