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  • Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

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    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate...

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  • A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

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    A foundation model for generalizable disease detection from retinal images

    A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health...

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  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

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    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation...

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  • Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

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    Beware of acute corneal oedema after SLT in selected patients

    Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT)...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Lamina cribrosa in glaucoma

Experimental Paper of the Month

Lamina cribrosa in glaucoma

Author(s): Downs JC (1), Girkin CA 1 Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA....

January 31, 2017

The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection

Experimental Paper of the Month

The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection

Author(s): Yamamoto K (1), Sato K (1,2), Yukita M (1), Yasuda M (1), Omodaka K (1,2), Ryu M (1), Fujita K (3), Nishiguchi KM (4), Machida S (5,6),...

December 31, 2016

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine

Experimental Paper of the Month

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine

Author(s): Fini ME (1), Schwartz SG (2), Gao X (3), Jeong S (4), Patel N (5), Itakura T (6), Price MO (7), Price FW Jr (8), Varma R (9), Stamer WD...

November 30, 2016

Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses

Experimental Paper of the Month

Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses

Author(s): Khawaja AP(1), Cooke Bailey JN(2), Kang JH(3), Allingham RR(4), Hauser MA(5), Brilliant M(6), Budenz DL(7), Christen WG(8), Fingert...

October 31, 2016

Glaucoma related Proteomic Alterations in Human Retina Samples

Experimental Paper of the Month

Glaucoma related Proteomic Alterations in Human Retina Samples

Author(s): Funke S (1), Perumal N (1), Beck S (1), Gabel-Scheurich S (1), Schmelter C (1), Teister J (1), Gerbig C (1), Gramlich OW (1,2), Pfeiffer...

September 30, 2016

Predegenerated Schwann cells-a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity

Experimental Paper of the Month

Predegenerated Schwann cells-a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity

Author(s): Smedowski A (1,2,3), Liu X (4), Pietrucha-Dutczak M (1), Matuszek I (1), Varjosalo M (4), Lewin-Kowalik J (1) 1 Chair and Department of...

July 31, 2016

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Experimental Paper of the Month

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Author(s): Vithana EN (1), Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu...

June 30, 2016

The Potential of Human Stem Cells for the Study and Treatment of Glaucoma

Experimental Paper of the Month

The Potential of Human Stem Cells for the Study and Treatment of Glaucoma

Author(s): Chamling X (1), Sluch VM (2), Zack DJ (2) 1 Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of...

May 31, 2016

GluA2 Trafficking Is Involved in Apoptosis of Retinal Ganglion Cells Induced by Activation of EphB/EphrinB Reverse Signaling in a Rat Chronic Ocular Hypertension Model

Experimental Paper of the Month

GluA2 Trafficking Is Involved in Apoptosis of Retinal Ganglion Cells Induced by Activation of EphB/EphrinB Reverse Signaling in a Rat Chronic Ocular Hypertension Model

Author(s): Dong LD (1), Gao F (2), Wang XH (1), Miao Y (1), Wang SY (1), Wu Y (1), Li F (1), Wu J (2), Cheng XL (3), Sun XH (2), Yang XL (1), Wang...

May 31, 2016

Transplanted neurons integrate into adult retinas and respond to light

Experimental Paper of the Month

Transplanted neurons integrate into adult retinas and respond to light

Author(s): Venugopalan P (1,2), Wang Y (2), Nguyen T (2), Huang A (2), Muller KJ (1,3), Goldberg JL (1,2,4) 1 Neuroscience Program, University of...

April 30, 2016

Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model

Experimental Paper of the Month

Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model

Author(s): Noristani R (1), Kuehn S (1), Stute G (1), Reinehr S (1), Stellbogen M (1), Dick HB (1), Joachim SC (2) 1 Experimental Eye Research...

March 31, 2016

Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport

Experimental Paper of the Month

Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport

Author(s): Kleesattel D, Crish SD, Inman DM PURPOSE: Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally...

January 31, 2016

Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy

Experimental Paper of the Month

Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy

Author(s): Van Bergen NJ (1), Crowston JG (1), Craig JE (2), Burdon KP (2), Kearns LS (1), Sharma S (2), Hewitt AW (1), Mackey DA (3), Trounce IA...

December 31, 2015

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma

Experimental Paper of the Month

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma

Author(s): Roubeix C (1,2,3), Godefroy D (4,5,6), Mias C (7), Sapienza A (8,9,10), Riancho L (11,12,13), Degardin J (14,15,16), Fradot V...

November 30, 2015

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

Experimental Paper of the Month

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

Author(s): Cueva Vargas JL (1), Osswald IK (2), Unsain N (3), Aurousseau MR (2), Barker PA (3), Bowie D (2), Di Polo A (4) 1 Department of...

October 31, 2015

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

Experimental Paper of the Month

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

Author(s): Takihara Y (1), Inatani M (2), Eto K (3), Inoue T (4), Kreymerman A (5), Miyake S (6), Ueno S (7), Nagaya M (7), Nakanishi A (7), Iwao K...

September 30, 2015

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat

Experimental Paper of the Month

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat

Author(s): Bogner B (1), Boye SL (2), Min SH (2), Peterson JJ (2), Ruan Q (2), Zhang Z (1), Reitsamer HA (1), Hauswirth WW (2), Boye SE (2) 1...

July 31, 2015

In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma

Experimental Paper of the Month

In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma

Author(s): Bosco A (1), Romero CO (2), Ambati BK (3), Vetter ML (2) 1 Department of Neurobiology & Anatomy, University of Utah;...

June 30, 2015

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Experimental Paper of the Month

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Author(s): Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS,...

April 30, 2015

Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types

Experimental Paper of the Month

Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types

Author(s): El-Danaf RN (1), Huberman AD (2) 1 Department of Neurosciences, Neurobiology Section in the Division of Biological Sciences, and...

March 31, 2015

Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma

Experimental Paper of the Month

Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma

Author(s): Stankowska DL (1), Minton AZ (2), Rutledge MD (3), Mueller BH (4), Phatak NR (5), He S (6), Ma HY (7), Forster MJ (8), Yorio T (9),...

February 28, 2015

Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma

Experimental Paper of the Month

Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma

Author(s): Wu J (1), Zhang S (1), Nickerson JM (2), Gao F (3), Sun Z (4), Chen X (3), Zhang S (3), Zhang R (3), Gao F (3), Chen J (3), Luo Y (3),...

January 31, 2015

Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo

Experimental Paper of the Month

Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo

Author(s): Guo L(1), Davis B(1), Nizari S(1), Normando EM(2), Shi H(3), Galvao J(1), Turner L(1), Shi J(4), Clements M(5), Parrinello S(5),...

December 31, 2014

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

Experimental Paper of the Month

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

Author(s): Springelkamp H, Höhn R, Mishra A, Hysi PG, Khor CC, Loomis SJ, Bailey JN, Gibson J, Thorleifsson G, Janssen SF, Luo X, Ramdas WD,...

November 30, 2014

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

Experimental Paper of the Month

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

Author(s): Hysi PG(1), Cheng CY(2), Springelkamp H(3), Macgregor S(4), Bailey JN(5), Wojciechowski R(6), Vitart V(7), Nag A(8), Hewitt AW(9), Höhn...

October 31, 2014