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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Do patients with glaucoma have difficulty recognising faces?

Clinical paper of the month

Do patients with glaucoma have difficulty recognising faces?

Author(s): Glen FC, Crabb DP, Smith ND, Burton R, Garway-Heath DF. Department of Optometry and Visual Science, City University London, Northampton...

June 30, 2012

Prevalence of cognitive impairment, depression, and anxiety symptoms among older adults with glaucoma

Clinical paper of the month

Prevalence of cognitive impairment, depression, and anxiety symptoms among older adults with glaucoma

Author(s): Yochim BP, Mueller AE, Kane KD, Kahook MY. Department of Psychology, University of Colorado at Colorado Springs, Colorado Springs...

May 31, 2012

The effect of thin, thick, and normal corneas on Goldmann intraocular pressure measurements and correction formulae in individual eyes

Clinical paper of the month

The effect of thin, thick, and normal corneas on Goldmann intraocular pressure measurements and correction formulae in individual eyes

Author(s): Park SJ, Ang GS, Nicholas S, Wells AP. Eye Department, Wellington Hospital, Capital and Coast District Health Board, Wellington, New...

April 30, 2012

Cataract surgery after trabeculectomy: the effect on trabeculectomy function

Clinical paper of the month

Cataract surgery after trabeculectomy: the effect on trabeculectomy function

Author(s): Husain R, Liang S, Foster PJ, Gazzard G, Bunce C, Chew PT, Oen FT, Khaw PT, Seah SK, Aung T FRCS(Edin), Singapore National Eye Center,...

March 31, 2012

Outcomes of different management options for malignant glaucoma: a retrospective study

Clinical paper of the month

Outcomes of different management options for malignant glaucoma: a retrospective study

Author(s): Debrouwere V, Stalmans P, Van Calster J, Spileers W, Zeyen T, Stalmans I. Department of Ophthalmology, Kapucijnenvoer 33, 3000, Leuven,...

February 29, 2012

Optic nerve sheath diameter in normal-tension glaucoma patients

Clinical paper of the month

Optic nerve sheath diameter in normal-tension glaucoma patients

Author(s): Jaggi GP, Miller NR, Flammer J, Weinreb RN, Remonda L, Killer HE. Kantonsspital Aarau, Buchserstrasse, CH-5001 Aarau, Switzerland;...

January 31, 2012

The Association between Glaucomatous and Other Causes of Optic Neuropathy and Sleep Apnea.

Clinical paper of the month

The Association between Glaucomatous and Other Causes of Optic Neuropathy and Sleep Apnea.

Author(s): Stein JD, Kim DS, Mundy KM, Talwar N, Nan B, Chervin RD, Musch DC. Department of Ophthalmology and Visual Sciences, University of...

December 31, 2011

Shrinkage of the scleral canal during cupping reversal in children.

Clinical paper of the month

Shrinkage of the scleral canal during cupping reversal in children.

Author(s): Mochizuki H, Lesley AG, Brandt JD. Department of Ophthalmology and Vision Science, University of California, Davis; Department of...

November 30, 2011

Intraocular Pressure Control and Long-term Visual Field Loss in the Collaborative Initial Glaucoma Treatment Study

Clinical paper of the month

Intraocular Pressure Control and Long-term Visual Field Loss in the Collaborative Initial Glaucoma Treatment Study

Author(s): Musch DC, Gillespie BW, Niziol LM, Lichter PR, Varma R; CIGTS Study Group. Department of Ophthalmology and Visual Sciences, University...

October 31, 2011

Vision loss and recovery after trabeculectomy: risk and associated risk factors

Clinical paper of the month

Vision loss and recovery after trabeculectomy: risk and associated risk factors

Author(s): Francis BA, Hong B, Winarko J, Kawji S, Dustin L, Chopra V. Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine,...

September 30, 2011

Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma

Clinical paper of the month

Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma

Author(s): Ren R, Wang N, Zhang X, Cui T, Jonas JB Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital,...

August 31, 2011

Lifestyle and risk of developing open-angle glaucoma: the Rotterdam study

Clinical paper of the month

Lifestyle and risk of developing open-angle glaucoma: the Rotterdam study

Author(s): Ramdas WD, Wolfs RC, Hofman A, de Jong PT, Vingerling JR, Jansonius NM. Department of Ophthalmology, Erasmus Medical Center Rotterdam,...

July 31, 2011

Risk factors for visual field progression in treated glaucoma

Clinical paper of the month

Risk factors for visual field progression in treated glaucoma

Author(s): De Moraes CG, Juthani VJ, Liebmann JM, Teng CC, Tello C, Susanna R Jr, Ritch R. OBJECTIVE: To determine intraocular pressure...

June 30, 2011

The Relationship Between Components of Metabolic Syndrome and Open-Angle Glaucoma

Clinical paper of the month

The Relationship Between Components of Metabolic Syndrome and Open-Angle Glaucoma

Author(s): Newman-Casey PA, Talwar N, Nan B, Musch DC, Stein JD. Department of Ophthalmology and Visual Sciences, University of Michigan Medical...

May 31, 2011

A Randomized Trial of Brimonidine Versus Timolol in Preserving Visual Function: Results From the Low-pressure Glaucoma Treatment Study

Clinical paper of the month

A Randomized Trial of Brimonidine Versus Timolol in Preserving Visual Function: Results From the Low-pressure Glaucoma Treatment Study

Author(s): Krupin T, Liebmann JM, Greenfield DS, Ritch R, Gardiner S. Department of Ophthalmology, Feinberg School of Medicine, Northwestern...

April 30, 2011

Investigation of the Association between Helicobacter pylori Infection and Normal Tension Glaucoma

Clinical paper of the month

Investigation of the Association between Helicobacter pylori Infection and Normal Tension Glaucoma

Author(s): Kim JM, Kim SH, Park KH, Han SY, Shim HS. Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung...

March 31, 2011

Laminar and prelaminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls

Clinical paper of the month

Laminar and prelaminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls

Author(s): Agoumi Y, Sharpe GP, Hutchison DM, Nicolela MT, Artes PH, Chauhan BC. Department of Ophthalmology and Visual Sciences, Dalhousie...

February 28, 2011

Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection

Clinical paper of the month

Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection

Author(s): Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S. Goldschleger Eye Institute, Sheba Medical...

January 31, 2011

Predicting visual function from the measurements of retinal nerve fiber layer structure

Clinical paper of the month

Predicting visual function from the measurements of retinal nerve fiber layer structure

Author(s): Zhu H, Crabb DP, Schlottmann PG, Lemij HG, Reus NJ, Healey PR, Mitchell P, Ho T, Garway-Heath DF Department of Optometry and Visual...

December 31, 2010

Canadian Glaucoma Study: 3. Impact of risk factors and intraocular pressure reduction on the rates of visual field change

Clinical paper of the month

Canadian Glaucoma Study: 3. Impact of risk factors and intraocular pressure reduction on the rates of visual field change

Author(s): Chauhan BC, Mikelberg FS, Artes PH, Balazsi AG, LeBlanc RP, Lesk MR, Nicolela MT, Trope GE; Canadian Glaucoma Study Group Collaborators...

November 30, 2010

Incidence of glaucomatous visual field loss: a ten-year follow-up from the Rotterdam Study

Clinical paper of the month

Incidence of glaucomatous visual field loss: a ten-year follow-up from the Rotterdam Study

Author(s): Czudowska MA, Ramdas WD, Wolfs RC, Hofman A, De Jong PT, Vingerling JR, Jansonius NM Department of Epidemiology, Erasmus Medical Center,...

October 31, 2010

Anthropometric measures and their relation to incident primary open-angle glaucoma

Clinical paper of the month

Anthropometric measures and their relation to incident primary open-angle glaucoma

Author(s): Pasquale LR, Willett WC, Rosner BA, Kang JH Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary,...

September 30, 2010

Effect of sleeping in a head-up position on intraocular pressure in patients with glaucoma

Clinical paper of the month

Effect of sleeping in a head-up position on intraocular pressure in patients with glaucoma

Author(s): Buys YM, Alasbali T, Jin YP, Smith M, Gouws P, Geffen N, Flanagan JG, Shapiro CM, Trope GE Department of Ophthalmology and Vision...

August 31, 2010

Clinical classification of childhood glaucomas

Clinical paper of the month

Clinical classification of childhood glaucomas

Author(s): Yeung HH, Walton DS Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA....

July 31, 2010

Effect of patient's life expectancy on the cost-effectiveness of treatment for ocular hypertension

Clinical paper of the month

Effect of patient's life expectancy on the cost-effectiveness of treatment for ocular hypertension

Author(s): Kymes SM, Plotzke MR, Kass MA, Boland MV, Gordon MO OBJECTIVE: To assess the influence of expected life span on the cost-effectiveness...

June 30, 2010