Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Experimental Paper of the Month

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...

September 30, 2017

In a young patient with acute congestive angle closure or recurrent angle closure in the presence of a patent laser iridotomy, the underlying cause is usually plateau iris configuration

Tip of the month

In a young patient with acute congestive angle closure or recurrent angle closure in the presence of a patent laser iridotomy, the underlying cause is usually plateau iris configuration

The Science behind the Tip Plateau iris configuration is characterised by a closed anterior chamber angle in association with a flat iris plane and...

July 31, 2017

Risk Factors for Rapid Glaucoma Disease Progression

Clinical paper of the month

Risk Factors for Rapid Glaucoma Disease Progression

Author(s): Chan TCW (1), Bala C (2), Siu A (3), Wan F (3), White A (4) 1 University of Sydney, Sydney, Australia. 2 Macquarie University, Sydney,...

July 31, 2017

Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss

Experimental Paper of the Month

Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss

Author(s): 1 Neuroscience Graduate Program, Vanderbilt UniversityNashville, TN, United States. 2 Department of Ophthalmology and Visual Sciences,...

July 31, 2017

The chronic use of prostaglandin analogues may lead to a modest underestimation of IOP when measured by Goldmann applanation tonometry

Tip of the month

The chronic use of prostaglandin analogues may lead to a modest underestimation of IOP when measured by Goldmann applanation tonometry

The Science behind the Tip Corneal hysteresis is a biomechanical property of the cornea relating to its elasticity. The measurement of corneal...

June 30, 2017

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Clinical paper of the month

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...

June 30, 2017

Regulation of intraocular pressure by microRNA cluster miR-143/145

Experimental Paper of the Month

Regulation of intraocular pressure by microRNA cluster miR-143/145

Author(s): Li X (1,2), Zhao F (3,4), Xin M (5), Li G (6), Luna C (6), Li G (1), Zhou Q (4), He Y (2), Yu B (4), Olson E (7), Gonzalez P (6), Wang S...

June 30, 2017

In a patient with glaucoma who has unexplained hair loss, stop topical beta-blocker treatment

Tip of the month

In a patient with glaucoma who has unexplained hair loss, stop topical beta-blocker treatment

The Science behind the Tip Beta adrenergic receptor blocking eye drops are often used to reduce the intraocular pressure. Because of absorption...

May 31, 2017

Neuroprotection for glaucoma: Requirements for clinical translation

Clinical paper of the month

Neuroprotection for glaucoma: Requirements for clinical translation

Author(s): Levin LA (1), Crowe ME (2), Quigley HA (3); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants 1...

May 31, 2017

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Experimental Paper of the Month

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Author(s): Zhu W (1), Jain A (2), Gramlich OW (3), Tucker BA (3), Sheffield VC (4), Kuehn MH (1) 1 Department of Ophthalmology and Visual Sciences,...

May 31, 2017

Patients with normal tension glaucoma who develop a branch retinal vein occlusion should be monitored with greater care

Tip of the month

Patients with normal tension glaucoma who develop a branch retinal vein occlusion should be monitored with greater care

The Science behind the Tip If a branch retinal vein occlusion (BRVO) occurs in a patient with normal tension glaucoma, it tends to occur in the eye...

April 30, 2017

Visual function may improve after trabeculectomy in some adults with moderately advanced glaucoma

Tip of the month

Visual function may improve after trabeculectomy in some adults with moderately advanced glaucoma

The Science behind the Tip We were taught that visual field loss from glaucoma is irreversible and that our interventions could at best, preserve...

March 31, 2017

The challenge of regenerative therapies for the optic nerve in glaucoma

Clinical paper of the month

The challenge of regenerative therapies for the optic nerve in glaucoma

Author(s): Calkins DJ (1), Pekny M (2), Cooper ML (3), Benowitz L (4); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration...

March 31, 2017

The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations

Experimental Paper of the Month

The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations

Author(s): Midgett DE (1), Pease ME (2), Jefferys JL (2), Patel M (3), Franck C (3), Quigley HA (2), Nguyen TD (4) 1 Department of Mechanical...

March 31, 2017

The regular (and sometimes clandestine) application of periocular corticosteroid cream can induce glaucoma in susceptible individuals

Tip of the month

The regular (and sometimes clandestine) application of periocular corticosteroid cream can induce glaucoma in susceptible individuals

The Science behind the Tip Steroid-induced ocular hypertension and glaucoma is typically associated with topical steroid therapy and presents with...

February 28, 2017

Posner-Schlossman Syndrome

Clinical paper of the month

Posner-Schlossman Syndrome

Author(s): Megaw R (1), Agarwal PK (2) 1 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of...

February 28, 2017

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

Experimental Paper of the Month

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

Author(s): Springelkamp H (1,2), Iglesias AI, Mishra A (3,4), Höhn R (5,6), Wojciechowski R, Khawaja AP (7), Nag A (8), Wang YX (9,10), Wang JJ...

February 28, 2017

Glaucoma Risk Alleles in the Ocular Hypertension Treatment Study

Clinical paper of the month

Glaucoma Risk Alleles in the Ocular Hypertension Treatment Study

Author(s): Scheetz TE (1), Faga B (1), Ortega L (2), Roos BR (1), Gordon MO (3), Kass MA (3), Wang K (4), Fingert JH (5) 1 Department Ophthalmology...

January 31, 2017

Lamina cribrosa in glaucoma

Experimental Paper of the Month

Lamina cribrosa in glaucoma

Author(s): Downs JC (1), Girkin CA 1 Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA....

January 31, 2017

Patients with neovascular glaucoma should be referred to a general physician as management of their underlying systemic disease should increase their life expectancy

Tip of the month

Patients with neovascular glaucoma should be referred to a general physician as management of their underlying systemic disease should increase their life expectancy

The Science behind the Tip Most patients with neovascular glaucoma have retinal ischaemia secondary to either proliferative diabetic retinopathy,...

December 31, 2016

New classes of glaucoma medications

Clinical paper of the month

New classes of glaucoma medications

Author(s): Schehlein EM (1), Novack GD, Robin AL 1 a University of Maryland School of Medicine, Department of Ophthalmology and Visual Sciences,...

December 31, 2016

The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection

Experimental Paper of the Month

The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection

Author(s): Yamamoto K (1), Sato K (1,2), Yukita M (1), Yasuda M (1), Omodaka K (1,2), Ryu M (1), Fujita K (3), Nishiguchi KM (4), Machida S (5,6),...

December 31, 2016

The risk of secondary haemorrhage after hyphaema can be reduced by using topical steroids and oral tranexamic acid

Tip of the month

The risk of secondary haemorrhage after hyphaema can be reduced by using topical steroids and oral tranexamic acid

The Science behind the Tip A hyphaema is a common and usually innocuous consequence of blunt injury or ocular surgery. However, the secondary...

November 30, 2016

Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial

Clinical paper of the month

Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial

Author(s): Azuara-Blanco A (1), Burr J (2), Ramsay C (3), Cooper D (3), Foster PJ (4), Friedman DS (5), Scotland G (6), Javanbakht M (7), Cochrane...

November 30, 2016