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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Effect of trabeculectomy on corneal endothelial cell loss

Clinical paper of the month

Effect of trabeculectomy on corneal endothelial cell loss

Author(s): Hirooka K (1), Nitta E (2), Ukegawa K (2), Sato S (2), Kiuchi Y (3) 1 Ophthalmology and Visual Science, Hiroshima University, Hiroshima,...

July 31, 2019

Risk factors for disease progression in low-teens normal-tension glaucoma

Clinical paper of the month

Risk factors for disease progression in low-teens normal-tension glaucoma

Author(s): Baek SU (1,2), Ha A (3,4), Kim DW (5,6), Jeoung JW (3,4), Park KH (3,4), Kim YK (7,4) 1 Department of Ophthalmology, Hallym University...

June 30, 2019

Exogenous influences on intraocular pressure

Clinical paper of the month

Exogenous influences on intraocular pressure

Author(s): Kim YW (1), Park KH (2) 1 Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. 2 Ophthalmology, Seoul National...

May 31, 2019

Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial

Clinical paper of the month

Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial

Author(s): Gazzard G (1), Konstantakopoulou E (2), Garway-Heath D (2), Garg A (2), Vickerstaff V (3), Hunter R (4), Ambler G (5), Bunce C (6),...

April 30, 2019

Visual Crowding in Glaucoma

Clinical paper of the month

Visual Crowding in Glaucoma

Author(s): Ogata NG (1), Boer ER (2), Daga FB (1), Jammal AA (1), Stringham JM (1), Medeiros FA (1) 1 Duke Eye Center, Department of Ophthalmology,...

March 31, 2019

The Effects of Optic Nerve Head Tilt on Visual Field Defects in Myopic Normal Tension Glaucoma: The Inter-eye Comparison Study

Clinical paper of the month

The Effects of Optic Nerve Head Tilt on Visual Field Defects in Myopic Normal Tension Glaucoma: The Inter-eye Comparison Study

Author(s): Choi JH (1), Han JC, Kee C 1 Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,...

February 28, 2019

Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review

Clinical paper of the month

Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review

Author(s): Patel P (1), Harris A (1), Toris C (2), Tobe L (1), Lang M (1), Belamkar A (1), Ng A (1), Verticchio Vercellin AC (3,4), Mathew S (1),...

January 31, 2019

Artificial intelligence and deep learning in ophthalmology

Clinical paper of the month

Artificial intelligence and deep learning in ophthalmology

Author(s): Ting DSW (1), Pasquale LR (2), Peng L (3), Campbell JP (4), Lee AY (5), Raman R (6), Tan GSW (7), Schmetterer L (7,8,9,10), Keane PA...

December 31, 2018

Familial Risks of Glaucoma in the Population of Sweden

Clinical paper of the month

Familial Risks of Glaucoma in the Population of Sweden

Author(s): Li X (1), Sundquist J (1,2,3), Zöller B (1), Sundquist K (1,2,3) 1 Center for Primary Health Care Research, Lund University, Sweden. 2...

November 30, 2018

The Magnitude of IOP Elevation Associated with Eye Rubbing

Clinical paper of the month

The Magnitude of IOP Elevation Associated with Eye Rubbing

Author(s): Turner DC (1), Girkin CA (2), Downs JC (3) 1 Department of Vision Sciences, School of Optometry, University of Alabama at Birmingham,...

October 31, 2018

Structural reversal of disc cupping after trabeculectomy alters Bruch's membrane opening-based parameters to assess neuroretinal rim

Clinical paper of the month

Structural reversal of disc cupping after trabeculectomy alters Bruch's membrane opening-based parameters to assess neuroretinal rim

Author(s): Gietzelt C (1), Lemke J (1), Schaub F (1), Hermann MM (1), Dietlein TS (1), Cursiefen C (1), Enders P (2), Heindl LM (1) 1 Department of...

September 30, 2018

Tolerable rates of visual field progression in a population-based sample of patients with glaucoma

Clinical paper of the month

Tolerable rates of visual field progression in a population-based sample of patients with glaucoma

Author(s): Salonikiou A (1), Founti P (1,2), Kilintzis V (1), Antoniadis A (1), Anastasopoulos E (1), Pappas T (1), Raptou A (1), Topouzis F (1) 1...

July 31, 2018

Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients

Clinical paper of the month

Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients

Author(s): Hou H (1), Shoji T (2), Zangwill LM (1), Moghimi S (3), Saunders LJ (1), Hasenstab K (1), Ghahari E (1), Manalastas PIC (1), Akagi T...

June 30, 2018

What have we learned about exfoliation syndrome since its discovery by John Lindberg 100 years ago?

Clinical paper of the month

What have we learned about exfoliation syndrome since its discovery by John Lindberg 100 years ago?

Author(s): Nazarali S (1), Damji F (2), Damji KF (3) 1 Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. 2 School of Kinesiology,...

May 31, 2018

Twenty-year outcomes in patients with newly diagnosed glaucoma: mortality and visual function

Clinical paper of the month

Twenty-year outcomes in patients with newly diagnosed glaucoma: mortality and visual function

Author(s): King C (1), Sherwin JC (1), Ratnarajan G (2), Salmon JF (1) 1 Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust,...

April 30, 2018

Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health

Clinical paper of the month

Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health

Author(s): Zhu MM (1), Lai JSM (1), Choy BNK (1), Shum JWH (1), Lo ACY (1), Ng ALK (1), Chan JCH (1), So KF (1,2,3,4) 1 Department of...

March 31, 2018

The Iridocorneal Endothelial Syndrome

Clinical paper of the month

The Iridocorneal Endothelial Syndrome

Author(s): Silva L (1), Najafi A (2), Suwan Y (3), Teekhasaenee C (4), Ritch R (2) 1 Einhorn Clinical Research Center, The New York Eye and Ear...

February 28, 2018

Detecting Visual Field Progression

Clinical paper of the month

Detecting Visual Field Progression

Author(s): Aref AA (1), Budenz DL (2) 1 Illinois Eye & Ear Infirmary, University of Illinois at Chicago College of Medicine, Chicago, Illinois....

January 31, 2018

Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects

Clinical paper of the month

Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects

Author(s): Sawada Y (1), Araie M (2), Ishikawa M (3), Yoshitomi T (3) 1 Department of Ophthalmology, Akita University Graduate School of Medicine,...

December 31, 2017

Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma

Clinical paper of the month

Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma

Author(s): Akagi T (1), Zangwill LM (2), Saunders LJ (2), Yarmohammadi A (2), Manalastas PIC (2), Suh MH (3), Girkin CA (4), Liebmann JM (5),...

November 30, 2017

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis

Clinical paper of the month

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis

Author(s): Aschard H (1), Kang JH (2), Iglesias AI (3), Hysi P (4), Cooke Bailey JN (5,6), Khawaja AP (7), Allingham RR (8), Ashley-Koch A (9), Lee...

October 31, 2017

Rates of glaucomatous visual field change after trabeculectomy

Clinical paper of the month

Rates of glaucomatous visual field change after trabeculectomy

Author(s): Baril C (1), Vianna JR (1), Shuba LM (1), Rafuse PE (1), Chauhan BC (1), Nicolela MT (1) 1 Department of Ophthalmology and Visual...

September 30, 2017

Risk Factors for Rapid Glaucoma Disease Progression

Clinical paper of the month

Risk Factors for Rapid Glaucoma Disease Progression

Author(s): Chan TCW (1), Bala C (2), Siu A (3), Wan F (3), White A (4) 1 University of Sydney, Sydney, Australia. 2 Macquarie University, Sydney,...

July 31, 2017

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Clinical paper of the month

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...

June 30, 2017

Neuroprotection for glaucoma: Requirements for clinical translation

Clinical paper of the month

Neuroprotection for glaucoma: Requirements for clinical translation

Author(s): Levin LA (1), Crowe ME (2), Quigley HA (3); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants 1...

May 31, 2017