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  • Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular contact and diagnosing angle closure.1 AS-OCT and...

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    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular...

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  • Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide....

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    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic...

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  • Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of...

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    Retinal Nerve Fiber Layer Optical Texture Analysis

    Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate...

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  • A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals. This study provides novel insight into the genetic...

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    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals....

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  • Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...

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    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading...

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  • Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...

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    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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If glaucoma progresses despite seemingly controlled IOP, then it may be worthwhile investigating and treating obstructive sleep apnoea syndrome (OSAS)

Tip of the month

If glaucoma progresses despite seemingly controlled IOP, then it may be worthwhile investigating and treating obstructive sleep apnoea syndrome (OSAS)

The Science behind the Tip The exact physiopathology of glaucoma is still poorly understood, but the role of vascular dysregulation has become...

November 30, 2014

Per-operative use of anti-VEGF agents improves the chance of success of trabeculectomy

Tip of the month

Per-operative use of anti-VEGF agents improves the chance of success of trabeculectomy

The Science behind the Tip Anti-VEGF agents have been widely used in a variety of ocular diseases for their activity in decreasing blood vessel...

October 31, 2014

After the insertion of a drainage tube, the risk of a delayed supra-choroidal haemorrhage can be reduced by avoiding post-operative hypotony

Tip of the month

After the insertion of a drainage tube, the risk of a delayed supra-choroidal haemorrhage can be reduced by avoiding post-operative hypotony

The Science behind the Tip One of the most serious post-operative complications of tube-shunt surgery is a delayed supra-choroidal haemorrhage,...

September 30, 2014

Temporal placement of a laser peripheral iridotomy is safe and is less likely to result in linear dysphotopsia than if the PI is placed superiorly

Tip of the month

Temporal placement of a laser peripheral iridotomy is safe and is less likely to result in linear dysphotopsia than if the PI is placed superiorly

The Science behind the Tip To prevent pupil block, a laser peripheral iridotomy (PI) is the initial treatment for patients with primary...

July 31, 2014

Patients with pseudoexfoliation syndrome often have loss of hearing and should be referred for audiometry

Tip of the month

Patients with pseudoexfoliation syndrome often have loss of hearing and should be referred for audiometry

The Science behind the Tip Pseudoexfoliation syndrome is an important cause of glaucoma. It has been known for many years that pseudoexfoliation...

June 30, 2014

Dietary supplementation and glaucoma

Tip of the month

Dietary supplementation and glaucoma

The Science behind the Tip Dietary supplements belong to the broad group of complementary and alternative medicine (CAM). A recent survey in Canada...

May 31, 2014

Patients with pigmentary glaucoma respond well to laser trabeculoplasty, but steps must be taken to reduce the risk of the IOP spike that may occur immediately after the laser treatment

Tip of the month

Patients with pigmentary glaucoma respond well to laser trabeculoplasty, but steps must be taken to reduce the risk of the IOP spike that may occur immediately after the laser treatment

The Science behind the Tip Argon or selective laser trabeculoplasty (LT) is an established therapeutic option in the treatment of patients with...

April 30, 2014

It is important that glaucoma patients at risk of end-of-life visual impairment should be identified and treated accordingly

Tip of the month

It is important that glaucoma patients at risk of end-of-life visual impairment should be identified and treated accordingly

The Science behind the Tip The ultimate outcome measure of glaucoma treatment is visual impairment and blindness at the time of death. Based on a...

March 31, 2014

Perimetry should be undertaken soon after phacoemulsification and multifocal IOL implantation in patients with glaucoma, in order to establish new baseline parameters

Tip of the month

Perimetry should be undertaken soon after phacoemulsification and multifocal IOL implantation in patients with glaucoma, in order to establish new baseline parameters

The Science behind the Tip To determine change in visual function in patients with glaucoma, regular visual field testing is undertaken using...

February 28, 2014

The early diagnosis of glaucoma and early detection of glaucoma progression should be enhanced by the use of spectral domain OCT measurement of the neuro retinal rim

Tip of the month

The early diagnosis of glaucoma and early detection of glaucoma progression should be enhanced by the use of spectral domain OCT measurement of the neuro retinal rim

The Science behind the Tip Recent studies using spectral domain ocular coherence tomography (SD OCT) measurement of the optic disc margin show that...

January 31, 2014

Consider using preservative-free topical medication in patients with ocular surface disease

Tip of the month

Consider using preservative-free topical medication in patients with ocular surface disease

The Science behind the Tip Many glaucoma drops contain a preservative agent to minimise the risk of microbial contamination. Benzalconium chloride,...

November 30, 2013

Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short

Tip of the month

Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short

The Science behind the Tip Trabeculectomy surgery is a recognised risk factor for the subsequent development of cataract. Phacoemulsification with...

November 30, 2013

Generic drops can differ from brand drops and it may be necessary to monitor patients more closely after switching

Tip of the month

Generic drops can differ from brand drops and it may be necessary to monitor patients more closely after switching

The Science behind the Tip In order to be approved for general use, a generic drug has to show the criterion of essential similarity when compared...

October 31, 2013

The measurement of retinal nerve fibre thickness is helpful in determining which patients with ocular hypertension will develop glaucoma

Tip of the month

The measurement of retinal nerve fibre thickness is helpful in determining which patients with ocular hypertension will develop glaucoma

The Science behind the Tip In patients with ocular hypertension, moderate to severe retinal nerve fibre layer (RNFL) atrophy at baseline has been...

September 30, 2013

Post-traumatic angle-recession glaucoma is difficult to manage and surgical intervention is often required

Tip of the month

Post-traumatic angle-recession glaucoma is difficult to manage and surgical intervention is often required

The Science behind the Tip Anterior chamber angle recession is the commonest physical sign of previous blunt trauma to the eye. Raised intraocular...

June 30, 2013

The use of Ginkgo biloba may increase the risk of bleeding

Tip of the month

The use of Ginkgo biloba may increase the risk of bleeding

The Science behind the Tip Extracts of the leaves of the Asiatic tree Ginkgo biloba (GBE) provide protection against mitochondrial oxidative damage...

May 31, 2013

If surgery is required to control IOP in a patient with nanophthalmos, phacoemulsification with IOL implantation is a good option, but the complication rate is high

Tip of the month

If surgery is required to control IOP in a patient with nanophthalmos, phacoemulsification with IOL implantation is a good option, but the complication rate is high

The Science behind the Tip Nanophthalmos, small eye-big trouble, is a form of microophthalmos which is not accompanied by other congenital...

April 30, 2013

Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed

Tip of the month

Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed

The Science behind the Tip Malignant glaucoma or aqueous misdirection is a rare but feared complication of anterior segment surgery. It occurs in...

March 31, 2013

Young men of European ancestry with angle-closure require thorough investigation

Tip of the month

Young men of European ancestry with angle-closure require thorough investigation

The Science behind the Tip Primary angle closure glaucoma is rare in younger white adults, with an estimated age specific prevalence of 0.02% for...

February 28, 2013

Intravitreal steroids should be used with caution in patients with glaucoma

Tip of the month

Intravitreal steroids should be used with caution in patients with glaucoma

The Science behind the Tip In recent years it has become common practice to inject steroids into the vitreous to reduce macular oedema or ocular...

December 31, 2012

Long-term application of benzalkonium chloride increases the risk of filtration surgery failure

Tip of the month

Long-term application of benzalkonium chloride increases the risk of filtration surgery failure

The Science behind the Tip Glaucoma medication solutions usually contain the preservative benzalkonium chloride (BAK) in concentrations varying...

November 30, 2012

In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure

Tip of the month

In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure

The Science behind the Tip Raised intraocular pressure (IOP) in an eye with pseudoexfoliation syndrome results from pigment and exfoliation...

October 31, 2012

Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction

Tip of the month

Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction

The Science behind the Tip The enzyme carbonic anhydrase is present in the corneal endothelium where it is involved in fluid transport (1). It thus...

September 30, 2012

In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function

Tip of the month

In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function

The Science behind the Tip A recent study has shown that visual function is more likely to be preserved with brimonidine 2% than with timolol 0.5%...

June 30, 2012

A dry eye can hamper visual field test interpretation

Tip of the month

A dry eye can hamper visual field test interpretation

The Science behind the Tip During visual field (VF) testing the cornea of patients with severe dry eye condition can get dry to such an extent as...

May 31, 2012