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  • Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life

    The Science behind the Tip In contrast to underdiagnosis, which has been described in population-based studies as affecting 50% or more of glaucoma...

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    Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life

    Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life

    The Science behind the Tip In contrast to underdiagnosis, which has been described in...

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  • Peripapillary Retinoschisis in Glaucoma: A Systematic Review

    PURPOSE: The frequent use of optical coherence tomography increased the detection of peripapillary retinoschisis, which poses challenges in the...

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    Peripapillary Retinoschisis in Glaucoma: A Systematic Review

    Peripapillary Retinoschisis in Glaucoma: A Systematic Review

    PURPOSE: The frequent use of optical coherence tomography increased the detection of...

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  • Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study

    Purpose: To determine whether primary trabeculectomy or medical treatment produces better outcomes in terms of quality of life (QoL), clinical...

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    Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study

    Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study

    Purpose: To determine whether primary trabeculectomy or medical treatment produces better...

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  • Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension

    Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway undeniably plays a pivotal role in the pathophysiology...

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    Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension

    Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension

    Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

Pearl

Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

September 01, 2021

In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked

Tip of the month

In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked

Angle recession (AR) is a common complication after a blunt ocular trauma, and it is related to a higher risk of developing late-onset glaucoma...

July 31, 2021

Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma

Clinical paper of the month

Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma

Author(s): Erin A Boese (1), Wallace L M Alward (2), John H Fingert (2) Department Ophthalmology and Visual Sciences, Carver College of Medicine,...

July 31, 2021

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Experimental Paper of the Month

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Author(s): Guorong Li (1), Astrid F Nottebaum (2), Mitchell Brigell (3), Iris D Navarro (1), Ute Ipe (2), Sarthak Mishra (2), Maria Gomez-Caraballo...

July 31, 2021

Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial

Pearl

Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial

Pearls Manager: Hari Jayaram Patients newly diagnosed with Primary Angle Closure Glaucoma without advanced damage or Primary Angle Closure with IOP...

July 30, 2021

Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good

Tip of the month

Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good

Charles Bonnet syndrome (CBS) describes the presence of complex visual hallucinations with retained insight in the unreal nature of the phenomenon...

June 30, 2021

Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study

Clinical paper of the month

Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study

Author(s): N Douglas Baker (1), Howard S Barnebey (2), Marlene R Moster (3), Michael C Stiles (4), Steven D Vold (5), Anup K Khatana (6), Brian E...

June 30, 2021

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Experimental Paper of the Month

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Author(s): Pinkal D Patel (1), Yen-Lin Chen (2), Ramesh B Kasetti (1), Prabhavathi Maddineni (1), William Mayhew (1), J Cameron Millar (1), Dorette...

June 30, 2021

Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data

NGP Paper

Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data

Author(s): Giovanni Montesano (1), Harry A Quigley (2), David P Crabb (3) 1 City, University of London Optometry and Visual Sciences (G.M.,...

June 30, 2021

Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial

Pearl

Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial

Pearls Manager: Hari Jayaram Newly diagnosed patients with Ocular Hypertension or Open Angle Glaucoma were randomised to one of two treatment...

June 30, 2021

Consider focal pressure in case of poor filtration shortly after trabeculectomy

Tip of the month

Consider focal pressure in case of poor filtration shortly after trabeculectomy

Achieving a good filtration in the early postoperative period after trabeculectomy is associated with the procedure's long-term success (1)....

May 31, 2021

Ten-Year Clinical Outcomes of Acute Primary Angle Closure Randomized to Receive Early Phacoemulsification Versus Laser Peripheral Iridotomy

Clinical paper of the month

Ten-Year Clinical Outcomes of Acute Primary Angle Closure Randomized to Receive Early Phacoemulsification Versus Laser Peripheral Iridotomy

Author(s): Poemen P Chan (1,2), Fang Y Tang (1), Dexter Y Leung (1,3), Thomas C Lam (1,2), Nafees Baig (1,4,3), Clement C Tham (1,2,5) 1 Department...

May 31, 2021

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Experimental Paper of the Month

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Author(s): Puya Gharahkhani (1), Eric Jorgenson (2), Pirro Hysi (3), Anthony P Khawaja (4,5), Sarah Pendergrass (6) et al. 1 QIMR Berghofer Medical...

May 31, 2021

Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial

Pearl

Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial

Pearls Manager: Hari Jayaram The ZAP study was a single-centre randomised clinical trial performed in China to compare Laser Peripheral Iridotomy...

May 30, 2021

Ganglion cell-inner plexiform layer examination can help diagnose glaucoma in high myopia

Tip of the month

Ganglion cell-inner plexiform layer examination can help diagnose glaucoma in high myopia

Myopia can be associated with significant structural changes in the eye, including peripapillary atrophy, myopic macular degeneration and the...

April 30, 2021

Quality of Life in Primary Open-Angle Glaucoma and Cataract: An Analysis of VFQ-25 and OSDI from the iStent inject® Pivotal Trial

Clinical paper of the month

Quality of Life in Primary Open-Angle Glaucoma and Cataract: An Analysis of VFQ-25 and OSDI from the iStent inject® Pivotal Trial

Author(s): Thomas W Samuelson (1), Inder Paul Singh (2), Blake K Williamson (3), Heather Falvey (4), Won Chan Lee (5), Dawn Odom (6), David...

April 30, 2021

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Experimental Paper of the Month

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Author(s): Genetics of Exfoliation Syndrome Partnership For a full list of authors and affiliations please visit...

April 30, 2021

Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study

Pearl

Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study

Pearls Manager: Hari Jayaram The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...

April 30, 2021

My personal way to estimate whether a patient is at risk for wipeout following glaucoma surgery, is to perform a confrontation visual field with a red-topped bottle

Tip of the month

My personal way to estimate whether a patient is at risk for wipeout following glaucoma surgery, is to perform a confrontation visual field with a red-topped bottle

This should be done monocularly with the bottle moved from the area of scotoma towards fixation. One must ensure that the patient is constantly...

March 31, 2021

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Experimental Paper of the Month

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Author(s): Veselina Petrova (1), Craig S Pearson (2), Jared Ching (3,4,5), James R Tribble (6), Andrea G Solano (2), Yunfei Yang (5), Fiona M Love...

March 31, 2021

Correlations Between Subjective Evaluation of Quality of Life, Visual Field Loss, and Performance in Simulated Activities of Daily Living in Glaucoma Patients

NGP Paper

Correlations Between Subjective Evaluation of Quality of Life, Visual Field Loss, and Performance in Simulated Activities of Daily Living in Glaucoma Patients

Author(s): Line Azoulay-Sebban (1), Zhanlin Zhao (2,3), Ariel Zenouda (1), Marco Lombardi (1,4), Emmanuel Gutman (1), Emmanuelle Brasnu (4),...

March 30, 2021

Patient Co-operation is Essential to Achieve IOP-Lowering and Successful Outcomes

Pearl

Patient Co-operation is Essential to Achieve IOP-Lowering and Successful Outcomes

Pearls Manager: Hari Jayaram Adherence and continued usage of (“persistence”) prescribed glaucoma management is necessary to achieve sustained IOP...

March 30, 2021

Glaucoma associated with retinal detachment

Pearl

Glaucoma associated with retinal detachment

Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...

March 20, 2021

Consider IOP monitoring and prophylactic treatment in patients undergoing repeat intravitreal anti-VEGF injections

Tip of the month

Consider IOP monitoring and prophylactic treatment in patients undergoing repeat intravitreal anti-VEGF injections

Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections are now in widespread use for a plethora of retinal diseases. It is...

February 28, 2021

Anatomical Changes and Predictors of Angle Widening After Laser Peripheral Iridotomy: The Zhongshan Angle Closure Prevention Trial

Clinical paper of the month

Anatomical Changes and Predictors of Angle Widening After Laser Peripheral Iridotomy: The Zhongshan Angle Closure Prevention Trial

Author(s): Benjamin Y Xu (1), David S Friedman (2), Paul J Foster (3), Yu Jiang (4), Anmol A Pardeshi (5), Yuzhen Jiang (4), Beatriz Munoz (6), Tin...

February 28, 2021