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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma

Experimental Paper of the Month

Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma

Author(s): Fortune B, Burgoyne CF, Cull GA, Reynaud J, Wang L. Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research...

July 31, 2012

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

Experimental Paper of the Month

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

Author(s): Gallego BI, Salazar JJ, de Hoz R, Rojas B, Ramírez AI, Salinas-Navarro M, Ortín-Martínez A, Valiente-Soriano FJ, Avilés-Trigueros M,...

June 30, 2012

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

Experimental Paper of the Month

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

Author(s): Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT. Flaum Eye Institute, University of Rochester...

May 31, 2012

Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma

Experimental Paper of the Month

Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma

Author(s): Killer HE, Miller NR, Flammer J, Meyer P, Weinreb RN, Remonda L, Jaggi GP. Kantonsspital Aarau, CH-5001 Aarau, Switzerland;...

April 30, 2012

Multipotent Stem Cells from Trabecular Meshwork Become Phagocytic TM cells

Experimental Paper of the Month

Multipotent Stem Cells from Trabecular Meshwork Become Phagocytic TM cells

Author(s): Du Y, Roh DS, Mann MM, Funderburgh ML, Funderburgh JL, Schuman JS. UPMC Eye Center, Ophthalmology and Visual Science Research Center,...

March 31, 2012

A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients Changes of Fractional Anisotropy Detected by 3T Diffusion Tensor Imaging

Experimental Paper of the Month

A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients Changes of Fractional Anisotropy Detected by 3T Diffusion Tensor Imaging

Author(s): Engelhorn T, Michelson G, Waerntges S, Hempel S, El-Rafei A, Struffert T, Doerfler A. Department of Neuroradiology, University of...

February 29, 2012

Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration

Experimental Paper of the Month

Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration

Author(s): Laliberté AM, Macpherson TC, Micks T, Yan A, Hill KA Department of Biology, The University of Western Ontario, London, Ontario N6A 5B7,...

January 31, 2012

IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?

Experimental Paper of the Month

IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?

Author(s): Sigal IA, Yang H, Roberts MD, Grimm JL, Burgoyne CF, Demirel S, Downs JC. Ocular Biomechanics Laboratory. PURPOSE: To study the...

December 31, 2011

Genetic architecture of open angle glaucoma and related determinants

Experimental Paper of the Month

Genetic architecture of open angle glaucoma and related determinants

Author(s): Ramdas WD, Amin N, van Koolwijk LM, Janssens AC, Demirkan A, de Jong PT, Aulchenko YS, Wolfs RC, Hofman A, Rivadeneira F, Uitterlinden...

December 31, 2011

Identification of a Novel Locus for Autosomal Dominant Primary Open Angle Glaucoma on 4q35.1-q35.2.

Experimental Paper of the Month

Identification of a Novel Locus for Autosomal Dominant Primary Open Angle Glaucoma on 4q35.1-q35.2.

Author(s): Porter LF, Urquhart JE, O'Donoghue E, Spencer AF, Wade EM, Manson FD, Black GC. School of Biomedicine, The University of Manchester,...

November 30, 2011

24-Hour IOP Telemetry in the Non-human Primate: Implant System Performance and Initial Characterization of IOP At Multiple Timescales

Experimental Paper of the Month

24-Hour IOP Telemetry in the Non-human Primate: Implant System Performance and Initial Characterization of IOP At Multiple Timescales

Author(s): Downs JC, Burgoyne CF, Seigfreid WP, Reynaud JF, Strouthidis NG, Sallee V. Ocular Biomechanics Laboratory, Devers Eye Institute,...

October 31, 2011

Activated retinal glia mediated axon regeneration in experimental glaucoma

Experimental Paper of the Month

Activated retinal glia mediated axon regeneration in experimental glaucoma

Author(s): Lorber B, Guidi A, Fawcett JW, Martin KR. Centre for Brain Repair, University of Cambridge, Cambridge, UK. Glaucoma, a leading cause of...

September 30, 2011

During Glaucoma, {alpha}2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection

Experimental Paper of the Month

During Glaucoma, {alpha}2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection

Author(s): Bai Y, Sivori D, Woo SB, Neet KE, Lerner SF, Saragovi HU Lady Davis Institute-Jewish General Hospital PURPOSE: Glaucoma is an optic...

August 31, 2011

Ex vivo optical coherence tomography imaging of collector channels with a scanning endoscopic probe

Experimental Paper of the Month

Ex vivo optical coherence tomography imaging of collector channels with a scanning endoscopic probe

Author(s): Ren J, Gille HK, Wu J, Yang C. Departments of Electrical Engineering and. PURPOSE: To achieve high-fidelity optical coherence tomography...

July 31, 2011

Distortion of axonal cytoskeleton: an early sign of glaucomatous damage

Experimental Paper of the Month

Distortion of axonal cytoskeleton: an early sign of glaucomatous damage

Author(s): Huang X, Kong W, Zhou Y, Gregori G. PURPOSE: Glaucoma damages the retinal nerve fiber layer (RNFL). The purpose of this study was to...

June 30, 2011

Elastic modulus determination of normal and glaucomatous human trabecular meshwork

Experimental Paper of the Month

Elastic modulus determination of normal and glaucomatous human trabecular meshwork

Author(s): Last JA, Pan T, Ding Y, Reilly CM, Keller K, Acott TS, Fautsch MP, Murphy CJ, Russell P. Department of Chemical and Biological...

May 31, 2011

Early Gene Expression Changes in the Retinal Ganglion Cell Layer of a Rat Glaucoma Model

Experimental Paper of the Month

Early Gene Expression Changes in the Retinal Ganglion Cell Layer of a Rat Glaucoma Model

Author(s): Guo Y, Johnson EC, Cepurna WO, Dyck J, Doser T, Morrison JC. Ophthalmology, Oregon Health & Sciences University, Portland, United...

April 30, 2011

Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT)

Experimental Paper of the Month

Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT)

Author(s): Hann CR, Bentley MD, Vercnocke A, Ritman EL, Fautsch MP Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN...

March 31, 2011

Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma

Experimental Paper of the Month

Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma

Author(s): Comes N, Buie LK, Borrás T. Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. The...

February 28, 2011

Reversal of retinal ganglion cell dysfunction after surgical reduction of intraocular pressure

Experimental Paper of the Month

Reversal of retinal ganglion cell dysfunction after surgical reduction of intraocular pressure

Author(s): Sehi M, Grewal DS, Goodkin ML, Greenfield DS. Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller...

January 31, 2011

Qualitative and quantitative morphologic changes in the vasculature and extracellular matrix of the prelaminar optic nerve head in eyes with POAG

Experimental Paper of the Month

Qualitative and quantitative morphologic changes in the vasculature and extracellular matrix of the prelaminar optic nerve head in eyes with POAG

Author(s): Tektas OY, Lütjen-Drecoll E, Scholz M Institute of Anatomy II, University of Erlangen-Nuremberg, Erlangen, Germany....

November 30, 2010

Functional MRI signal changes in primary visual cortex corresponding to the central normal visual field of patients with primary open-angle glaucoma

Experimental Paper of the Month

Functional MRI signal changes in primary visual cortex corresponding to the central normal visual field of patients with primary open-angle glaucoma

Author(s): Qing G, Zhang S, Wang B, Wang N Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology...

October 31, 2010

Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve

Experimental Paper of the Month

Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve

Author(s): Dahlmann-Noor A, Vijay S, Jayaram H, Limb A, Khaw PT. The 3 most common causes of visual impairment and legal blindness in developed...

September 30, 2010

Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility

Experimental Paper of the Month

Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility

Author(s): Writing Committee fot the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society, Meguro A, Inoko H, Ota M, Mizuki N,...

August 31, 2010

Mitochondrial damage in the trabecular meshwork of patients with glaucoma

Experimental Paper of the Month

Mitochondrial damage in the trabecular meshwork of patients with glaucoma

Author(s): Izzotti A, Saccà SC, Longobardi M, Cartiglia C. Department of Health Sciences, University of Genoa, Genoa, Italy. izzotti@unige.it...

July 31, 2010