Posner-Schlossman Syndrome

Author(s): Megaw R (1), Agarwal PK (2)

1 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom; Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, EH3 9HA, United Kingdom. Electronic address: roly.megaw@ed.ac.uk.
2 Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, EH3 9HA, United Kingdom.

Posner-Schlossman syndrome (PSS), or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of non-granulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males . Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause. Successful disease management is often achieved by topical treatment, although systemic therapy and even surgical intervention may be required. We discuss our current understanding of PSS, from its pathophysiology through to recommended treatment options.

Copyright © 2016. Published by Elsevier Inc.

Surv Ophthalmol. 2016 Dec 21. pii: S0039-6257(16)30108-4. doi: 10.1016/j.survophthal.2016.12.005

PMID: 28012873

http://www.ncbi.nlm.nih.gov/pubmed/28012873

Clinical Paper of the Month manager: Andreas Boehm