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Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life
The Science behind the Tip In contrast to underdiagnosis, which has been described in...
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Peripapillary Retinoschisis in Glaucoma: A Systematic Review
PURPOSE: The frequent use of optical coherence tomography increased the detection of...
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Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Purpose: To determine whether primary trabeculectomy or medical treatment produces better...
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Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension
Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Retinal Nerve Fiber Layer Optical Texture Analysis
PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of...
February 12, 2024
A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.
PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals. This study provides novel insight into the genetic...
January 15, 2024
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...
January 15, 2024
Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression
The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...
January 15, 2024
Selective Laser Trabeculoplasty can be considered lifesaving treatment for the cornea when severe ocular disease co-exists with glaucoma
The Science behind the Tip Elevated intraocular pressure (IOP) and glaucoma are not uncommon in cases of cicatricial conjunctivitis (CC) such as...
December 17, 2023
Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering
Significance The “in silico–in vitro–in vivo” funnel holds significant potential for identifying targets to control cellular processes in research...
December 17, 2023
Validating Trend-Based End Points for Neuroprotection Trials in Glaucoma
PURPOSE: The purpose of this study was to evaluate the power of trend-based visual field (VF) progression end points against long-term development...
December 17, 2023
Risk Factors for Failure in Glaucoma Patients undergoing Microshunt Implantantion
PURPOSE: Evaluate risk factors for failure of Microshunt in glaucoma patients. DESIGN: Multicenter retrospective cohort study. METHODS:250 eyes...
December 17, 2023
How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2Ophthalmic Engineering & Innovation Laboratory, Singapore Eye...
November 15, 2023
European Glaucoma Society research priorities for glaucoma care
Background/Aims: The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that...
November 15, 2023
Exfoliation (pseudoexfoliation) syndrome (XFS, with or without glaucoma) is associated with clinically significant non-vascular systemic diseases.
The Science behind the Tip Systemic vascular dysfunction in XFS patients and statistically significant associations of systemic diseases with XFS...
November 15, 2023
BIG DATA SIG
SIG Corner Editor: Hana Abou Zeid Chair: Ananth Viswanathan Co-chair: Marta Pazos Mission To understand the genetic causes of glaucoma and the...
October 15, 2023
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
Author(s): Xikun Han 1,2,37 , Puya Gharahkhani 1,2,3,37, Andrew R. Hamel 4,5, Jue Sheng Ong 1, Miguel E. Rentería 2,3,6, Puja Mehta 4,5, Xianjun...
October 15, 2023
MERCURY‑3: a randomized comparison of netarsudil/latanoprost and bimatoprost/timolol in open‑angle glaucoma and ocular hypertension
Author(s): Ingeborg Stalmans1,2 · Kin Sheng Lim3 · Francesco Oddone4 · Marek Fichtl5,6 · Jose I. Belda7,8 · Anton Hommer9 · Guna Laganovska10 ·...
October 15, 2023
Consider sources of bias when using OCT angiography
The Science behind the Tip OCT angiography (OCTA) has gained great interest in glaucoma diagnosis (1, 2) and follow up(3). However, several...
October 15, 2023
Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer
Author(s): Ronen E Mukamel (1), Robert E Handsaker (2), Maxwell A Sherman (3), Alison R Barton (4), Margaux L A Hujoel (5), Steven A McCarroll (6),...
September 15, 2023
Long-term Impact of Immediate Versus Delayed Treatment of Early Glaucoma: Results From the Early Manifest Glaucoma Trial
PURPOSE: To compare long-term visual outcomes in the 2 arms of the Early Manifest Glaucoma Trial (EMGT) and determine if delayed treatment was...
September 15, 2023
OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing
The Science behind the Tip Thanks to its high reproducibility,1-3 OCT has become widely used for monitoring structural optic nerve changes in...
September 15, 2023
Intravitreal bevacizumab improves trabeculectomy survival at 12 months: the bevacizumab in trabeculectomy study-a randomised clinical trial
Author(s): John A Landers, Sean Mullany, Jamie E Craig 1 Ophthalmology, Flinders University of South Australia, Adelaide, South Australia,...
September 15, 2023
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Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema
The Science behind the Tip Patients undergoing anti-VEGF (vascular endothelial growth factor) therapy for age-related macular degeneration or...
August 31, 2023
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...
July 30, 2023
Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...
July 30, 2023
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...
July 30, 2023
Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...
July 30, 2023
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Ligand-induced activation and G protein coupling of prostaglandin F2α receptor
Author(s): Canrong Wu (1), Youwei Xu (2), Qian He (2), Dianrong Li (3), Jia Duan (2), Changyao Li (4,5), Chongzhao You (2), Han Chen (6), Weiliang...
June 30, 2023