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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular contact and diagnosing angle closure.1 AS-OCT and...

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    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular...

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  • Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide....

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    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic...

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  • Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of...

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    Retinal Nerve Fiber Layer Optical Texture Analysis

    Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate...

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  • A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals. This study provides novel insight into the genetic...

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    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals....

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  • Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...

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    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading...

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  • Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...

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    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Experimental Paper of the Month

Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

July 30, 2023

Angle Closure SIG

SIG Corner

Angle Closure SIG

SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

July 30, 2023

Ligand-induced activation and G protein coupling of prostaglandin F2α receptor

Experimental Paper of the Month

Ligand-induced activation and G protein coupling of prostaglandin F2α receptor

Author(s): Canrong Wu (1), Youwei Xu (2), Qian He (2), Dianrong Li (3), Jia Duan (2), Changyao Li (4,5), Chongzhao You (2), Han Chen (6), Weiliang...

June 30, 2023

Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss

Clinical paper of the month

Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss

Author(s): Aidan B Jackson (1), Keith R Martin (2), Michael A Coote (1), Felipe A Medeiros (3), Christopher A Girkin (4), Massimo A Fazio (4),...

June 30, 2023

Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

NGP Paper

Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

June 30, 2023

When interpreting RNFL OCT scans, attention should be paid to the presence of peripapillary retinoschisis

Tip of the month

When interpreting RNFL OCT scans, attention should be paid to the presence of peripapillary retinoschisis

Peripapillary retinoschisis (PPRS) occurs significantly more frequently in glaucoma patients (1%-6%) compared to healthy subjects (0.5%) (1). The...

June 30, 2023

Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia

Experimental Paper of the Month

Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia

Author(s): Mahmoud T KhalafAllah (1,2), Preston A Fuchs (3), Fred Nugen (3), Mustapha El Hamdaoui (3), Alexander Levy (4), David T Redden (5),...

May 31, 2023

Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression

Clinical paper of the month

Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression

Author(s): Felipe A Medeiros (1), Alessandro A Jammal (2) 1 Vision, Imaging and Performance Laboratory, Duke Eye Center, Duke University, Durham,...

May 31, 2023

OCT can be a helpful additional tool to differentiate glaucoma from other optic neuropathi

Tip of the month

OCT can be a helpful additional tool to differentiate glaucoma from other optic neuropathi

Differentiating between glaucomatous and non-glaucomatous optic neuropathies can be quite challenging. In addition to a thorough clinical history...

May 31, 2023

MIND diet lowers risk of open-angle glaucoma: the Rotterdam Study

Clinical paper of the month

MIND diet lowers risk of open-angle glaucoma: the Rotterdam Study

Author(s): Joëlle E Vergroesen (1,2), Tosca O E de Crom (2), Cornelia M van Duijn (3), Trudy Voortman (2,4), Caroline C W Klaver (1,2,5,6), Wishal...

April 30, 2023

Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

Tip of the month

Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

April 21, 2023

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma

Experimental Paper of the Month

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma

Author(s): Jae H Kang (1), Oana Zeleznik (1), Lisa Frueh (1), Jessica Lasky-Su (1), A Heather Eliassen (1,2), Clary Clish (3), Bernard A Rosner...

April 01, 2023

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

Experimental Paper of the Month

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

Author(s): W Daniel Stamer (1), Kristin M Perkumas (1), Min H Kang (2), Mohammed Dibas (3), Michael R Robinson (3), Douglas J Rhee (2) 1 Department...

March 31, 2023

Use corneal hysteresis to identify high-risk glaucoma patients

Tip of the month

Use corneal hysteresis to identify high-risk glaucoma patients

Identifying those patients at greater risk of disease progression is a key step in glaucoma management algorithms. Several variables have been...

March 31, 2023

The relationship between multiple deprivation and severity of glaucoma at diagnosis

NGP Paper

The relationship between multiple deprivation and severity of glaucoma at diagnosis

Author(s): Thai Ling Wong (1), Juan Lyn Ang (2), Sundeep Deol (2), Fiona Buckmaster (1), Alice D. McTrusty (1) and Andrew J. Tatham (1,2) 1 Centre...

March 30, 2023

Evidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening

Clinical paper of the month

Evidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening

Author(s): Chris Bradley (1), Kaihua Hou (2), Patrick Herbert (2), Mathias Unberath (2), Michael V Boland (3), Pradeep Ramulu (4), Jithin Yohannan...

March 01, 2023

Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway

Experimental Paper of the Month

Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway

Author(s): Yunsheng Qiao (1), Zhongmou Sun (2), Chen Tan (1), Junyi Lai (1), Xinghuai Sun (1,3,4), Junyi Chen (1,3,4) 1 Department of Ophthalmology...

February 28, 2023

Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): Baseline Results and Costs of a Cluster-Randomized Trial

Clinical paper of the month

Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): Baseline Results and Costs of a Cluster-Randomized Trial

Author(s): Lisa A Hark (1), Jason D Horowitz (2), Prakash Gorroochurn (3), Lisa Park (2), Qing Wang (2), Daniel F Diamond (2), Noga Harizman (2),...

February 28, 2023

Transconjunctival suturing techniques to treat over-filtration following trabeculectomy

Tip of the month

Transconjunctival suturing techniques to treat over-filtration following trabeculectomy

Hypotony is a recognised complication following filtration surgery such as trabeculectomy (1). Where this is due to over-filtration, intervention...

February 28, 2023

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance

Experimental Paper of the Month

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance

Author(s): Emmi Kapiainen (1,2,3), Harri Elamaa (1,2,3), Ilkka Miinalainen (2,3), Valerio Izzi (1,2,4,5), Lauri Eklund (1,2,3) 1 Oulu Center for...

January 31, 2023

Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial: Six-Year Results of Primary Selective Laser Trabeculoplasty versus Eye Drops for the Treatment of Glaucoma and Ocular Hypertension

Clinical paper of the month

Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial: Six-Year Results of Primary Selective Laser Trabeculoplasty versus Eye Drops for the Treatment of Glaucoma and Ocular Hypertension

Author(s): Gus Gazzard (1), Evgenia Konstantakopoulou (2), David Garway-Heath (3), Mariam Adeleke (4), Victoria Vickerstaff (5), Gareth Ambler (6),...

January 31, 2023

Be aware of obstructive sleep apnoea as a risk factor for the development or progression of glaucoma

Tip of the month

Be aware of obstructive sleep apnoea as a risk factor for the development or progression of glaucoma

Obstructive sleep apnoea (OSA) affects almost 1 billion people aged 30-69 years worldwide, of which 425 million have a moderate to severe OSA (1)....

January 31, 2023

Consider glaucoma drainage implant in patients with iridocorneal endothelial syndrome

Tip of the month

Consider glaucoma drainage implant in patients with iridocorneal endothelial syndrome

Glaucoma occurs in up to 70% of patients with iridocorneal endothelial syndrome (ICE) (1). Given the high failure rate of medical treatment,...

December 30, 2022

Estimating the Length of the Preclinical Detectable Phase for Open-Angle Glaucoma

Clinical paper of the month

Estimating the Length of the Preclinical Detectable Phase for Open-Angle Glaucoma

Author(s): Johan Aspberg (1,2), Anders Heijl (1,2), Boel Bengtsson (1) 1 Department of Clinical Sciences in Malmö, Ophthalmology, Lund University,...

December 29, 2022

Effect of trabeculectomy on the rate of progression of visual field damage

NGP Paper

Effect of trabeculectomy on the rate of progression of visual field damage

Author(s): Susanna Friederike Koenig (1,2), Giovanni Montesano (3,4), Clarissa Ern Hui Fang (5), David Paul Crabb (3), Hari Jayaram (5,4), Jonathan...

December 29, 2022