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  • Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular contact and diagnosing angle closure.1 AS-OCT and...

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    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular...

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  • Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide....

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    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic...

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  • Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of...

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    Retinal Nerve Fiber Layer Optical Texture Analysis

    Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate...

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  • A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals. This study provides novel insight into the genetic...

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    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals....

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  • Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...

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    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading...

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  • Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...

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    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury

Experimental Paper of the Month

Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury

Author(s): Ling-Ping Cen (1), Tsz Kin Ng (1,2,3), Jia-Jian Liang (1), Ciyan Xu (1), Xi Zhuang (1), Yu-Fen Liu (1,2), Shao-Lang Chen (1), Yanxuan Xu...

September 30, 2021

The glaucoma intensive treatment study: interim results from an ongoing longitudinal randomized clinical trial

NGP Paper

The glaucoma intensive treatment study: interim results from an ongoing longitudinal randomized clinical trial

Author(s): Boel Bengtsson (1), Christina Lindén (2), Anders Heijl (1), Sabina Andersson-Geimer (1), Johan Aspberg (1), Gauti Jóhannesson (2,3) 1...

September 30, 2021

Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

Pearl

Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

September 01, 2021

In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked

Tip of the month

In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked

Angle recession (AR) is a common complication after a blunt ocular trauma, and it is related to a higher risk of developing late-onset glaucoma...

July 31, 2021

Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma

Clinical paper of the month

Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma

Author(s): Erin A Boese (1), Wallace L M Alward (2), John H Fingert (2) Department Ophthalmology and Visual Sciences, Carver College of Medicine,...

July 31, 2021

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Experimental Paper of the Month

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Author(s): Guorong Li (1), Astrid F Nottebaum (2), Mitchell Brigell (3), Iris D Navarro (1), Ute Ipe (2), Sarthak Mishra (2), Maria Gomez-Caraballo...

July 31, 2021

Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial

Pearl

Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial

Pearls Manager: Hari Jayaram Patients newly diagnosed with Primary Angle Closure Glaucoma without advanced damage or Primary Angle Closure with IOP...

July 30, 2021

Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good

Tip of the month

Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good

Charles Bonnet syndrome (CBS) describes the presence of complex visual hallucinations with retained insight in the unreal nature of the phenomenon...

June 30, 2021

Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study

Clinical paper of the month

Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study

Author(s): N Douglas Baker (1), Howard S Barnebey (2), Marlene R Moster (3), Michael C Stiles (4), Steven D Vold (5), Anup K Khatana (6), Brian E...

June 30, 2021

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Experimental Paper of the Month

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Author(s): Pinkal D Patel (1), Yen-Lin Chen (2), Ramesh B Kasetti (1), Prabhavathi Maddineni (1), William Mayhew (1), J Cameron Millar (1), Dorette...

June 30, 2021

Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data

NGP Paper

Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data

Author(s): Giovanni Montesano (1), Harry A Quigley (2), David P Crabb (3) 1 City, University of London Optometry and Visual Sciences (G.M.,...

June 30, 2021

Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial

Pearl

Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial

Pearls Manager: Hari Jayaram Newly diagnosed patients with Ocular Hypertension or Open Angle Glaucoma were randomised to one of two treatment...

June 30, 2021

Consider focal pressure in case of poor filtration shortly after trabeculectomy

Tip of the month

Consider focal pressure in case of poor filtration shortly after trabeculectomy

Achieving a good filtration in the early postoperative period after trabeculectomy is associated with the procedure's long-term success (1)....

May 31, 2021

Ten-Year Clinical Outcomes of Acute Primary Angle Closure Randomized to Receive Early Phacoemulsification Versus Laser Peripheral Iridotomy

Clinical paper of the month

Ten-Year Clinical Outcomes of Acute Primary Angle Closure Randomized to Receive Early Phacoemulsification Versus Laser Peripheral Iridotomy

Author(s): Poemen P Chan (1,2), Fang Y Tang (1), Dexter Y Leung (1,3), Thomas C Lam (1,2), Nafees Baig (1,4,3), Clement C Tham (1,2,5) 1 Department...

May 31, 2021

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Experimental Paper of the Month

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Author(s): Puya Gharahkhani (1), Eric Jorgenson (2), Pirro Hysi (3), Anthony P Khawaja (4,5), Sarah Pendergrass (6) et al. 1 QIMR Berghofer Medical...

May 31, 2021

Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial

Pearl

Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial

Pearls Manager: Hari Jayaram The ZAP study was a single-centre randomised clinical trial performed in China to compare Laser Peripheral Iridotomy...

May 30, 2021

Ganglion cell-inner plexiform layer examination can help diagnose glaucoma in high myopia

Tip of the month

Ganglion cell-inner plexiform layer examination can help diagnose glaucoma in high myopia

Myopia can be associated with significant structural changes in the eye, including peripapillary atrophy, myopic macular degeneration and the...

April 30, 2021

Quality of Life in Primary Open-Angle Glaucoma and Cataract: An Analysis of VFQ-25 and OSDI from the iStent inject® Pivotal Trial

Clinical paper of the month

Quality of Life in Primary Open-Angle Glaucoma and Cataract: An Analysis of VFQ-25 and OSDI from the iStent inject® Pivotal Trial

Author(s): Thomas W Samuelson (1), Inder Paul Singh (2), Blake K Williamson (3), Heather Falvey (4), Won Chan Lee (5), Dawn Odom (6), David...

April 30, 2021

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Experimental Paper of the Month

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Author(s): Genetics of Exfoliation Syndrome Partnership For a full list of authors and affiliations please visit...

April 30, 2021

Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study

Pearl

Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study

Pearls Manager: Hari Jayaram The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...

April 30, 2021

My personal way to estimate whether a patient is at risk for wipeout following glaucoma surgery, is to perform a confrontation visual field with a red-topped bottle

Tip of the month

My personal way to estimate whether a patient is at risk for wipeout following glaucoma surgery, is to perform a confrontation visual field with a red-topped bottle

This should be done monocularly with the bottle moved from the area of scotoma towards fixation. One must ensure that the patient is constantly...

March 31, 2021

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Experimental Paper of the Month

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Author(s): Veselina Petrova (1), Craig S Pearson (2), Jared Ching (3,4,5), James R Tribble (6), Andrea G Solano (2), Yunfei Yang (5), Fiona M Love...

March 31, 2021

Correlations Between Subjective Evaluation of Quality of Life, Visual Field Loss, and Performance in Simulated Activities of Daily Living in Glaucoma Patients

NGP Paper

Correlations Between Subjective Evaluation of Quality of Life, Visual Field Loss, and Performance in Simulated Activities of Daily Living in Glaucoma Patients

Author(s): Line Azoulay-Sebban (1), Zhanlin Zhao (2,3), Ariel Zenouda (1), Marco Lombardi (1,4), Emmanuel Gutman (1), Emmanuelle Brasnu (4),...

March 30, 2021

Patient Co-operation is Essential to Achieve IOP-Lowering and Successful Outcomes

Pearl

Patient Co-operation is Essential to Achieve IOP-Lowering and Successful Outcomes

Pearls Manager: Hari Jayaram Adherence and continued usage of (“persistence”) prescribed glaucoma management is necessary to achieve sustained IOP...

March 30, 2021

Glaucoma associated with retinal detachment

Pearl

Glaucoma associated with retinal detachment

Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...

March 20, 2021