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  • Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular contact and diagnosing angle closure.1 AS-OCT and...

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    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular...

    Learn more...
  • Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide....

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    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic...

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  • Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of...

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    Retinal Nerve Fiber Layer Optical Texture Analysis

    Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate...

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  • A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals. This study provides novel insight into the genetic...

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    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals....

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  • Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...

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    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading...

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  • Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...

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    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Tip of the month

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Publishing date: November 2022 Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia...

December 19, 2022

Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma

Clinical paper of the month

Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma

Author(s): Owen M Siggs (1,2), Ayub Qassim (1), Xikun Han (3), Henry N Marshall (1), Sean Mullany (1), Weixiong He (3), Emmanuelle Souzeau (1),...

November 30, 2022

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

Experimental Paper of the Month

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

Author(s): Alireza Karimi (1), Reza Razaghi (1), Seyed Mohammadali Rahmati (2), Christopher A Girkin (1), J Crawford Downs (1) 1 Department of...

November 30, 2022

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Tip of the month

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia and blepharospasm. The elevated...

November 30, 2022

Long-Term Alcohol Consumption and Risk of Exfoliation Glaucoma/Glaucoma Suspect among US Health Professionals

Clinical paper of the month

Long-Term Alcohol Consumption and Risk of Exfoliation Glaucoma/Glaucoma Suspect among US Health Professionals

Author(s): Akiko Hanyuda (1), Bernard A Rosner (2), Janey L Wiggs (3), Kazuno Negishi (4), Louis R Pasquale (5), Jae H Kang (6) 1 Department of...

October 31, 2022

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Experimental Paper of the Month

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Author(s): Yang Pan (1), Akiko Suga (1), Itaru Kimura (2), Chojiro Kimura (3), Yuriko Minegishi (1), Mao Nakayama (1), Kazutoshi Yoshitake (1),...

October 31, 2022

Consider evaluation of corneal endothelial cell count in pseudoexfoliation patients undergoing surgery

Tip of the month

Consider evaluation of corneal endothelial cell count in pseudoexfoliation patients undergoing surgery

Corneal endothelial cell loss may lead to corneal decompensation with loss of vision, which may necessitate future endothelial transplantation for...

October 31, 2022

Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change

Clinical paper of the month

Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change

Author(s): Fengbin Lin (1), Shida Chen (1), Yunhe Song (1), Fei Li (1), Wei Wang (1), Zhenni Zhao (2), Xinbo Gao (1), Peiyuan Wang (1), Ling Jin...

September 30, 2022

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

Experimental Paper of the Month

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

Author(s): Liang Li (1), Fang Fang (2), Xue Feng (1), Pei Zhuang (1), Haoliang Huang (1), Pingting Liu (1), Liang Liu (1), Adam Z Xu (3), Lei S Qi...

September 30, 2022

When glaucoma is not glaucoma

Tip of the month

When glaucoma is not glaucoma

An increased excavation of the optic nerve head is usually associated to glaucoma, but other optic neuropathies may also display an increased...

September 30, 2022

External Validation and Clinical Applicability of Two Optical Coherence Tomography-Based Risk Calculators for Detecting Glaucoma

NGP Paper

External Validation and Clinical Applicability of Two Optical Coherence Tomography-Based Risk Calculators for Detecting Glaucoma

Author(s): Néstor Ventura-Abreu (1), Marc Biarnés (2), Sofia Batlle-Ferrando (1), María Teresa Carrión-Donderis (1), Rafael Castro-Domínguez (1),...

September 30, 2022

Next Generation Partnership SIG

SIG Corner

Next Generation Partnership SIG

SIG Corner Editor: Hana Abouzeid Chair: Gauti Johannesson Co-chairs: Esther Hoffmann, Anthony Khawaja, Francesco Oddone The goal of this SIG is to...

July 31, 2022

Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial

Clinical paper of the month

Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial

Author(s): Nevin W El-Nimri (1), Sasan Moghimi (1), Rafaella C Penteado (1), Elham Ghahari (1), Diya Yang (2), Nicole Brye (1), James Proudfoot...

July 31, 2022

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

Experimental Paper of the Month

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

Author(s): Feng Tian (1), Yuyan Cheng (2), Songlin Zhou (1), Qianbin Wang (1), Aboozar Monavarfeshani (3), Kun Gao (2), Weiqian Jiang (1), Riki...

July 30, 2022

Be aware of IOP elevation in children treated with systemic glucocorticoids

Tip of the month

Be aware of IOP elevation in children treated with systemic glucocorticoids

Children have a high risk of developing IOP elevation with topical steroid-treatment, but may also develop it after systemic treatment (1–3). The...

July 30, 2022

Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Clinical paper of the month

Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Author(s): Roger Chou (1), Shelley Selph (1,2), Ian Blazina (1), Christina Bougatsos (1), Rebecca Jungbauer (1), Rongwei Fu (1,3), Sara Grusing...

June 30, 2022

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Experimental Paper of the Month

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Author(s): Cheng Yang (1), Qianni Wu (2), Junqing Liu (3), Jingshan Mo (1), Xiangling Li (1,4), Chengduan Yang (1,5), Ziqi Liu (1), Jingbo Yang...

June 30, 2022

UGH syndrome should be considered in every pseudophakic patient, with active unilateral inflammation and elevated intraocular pressure

Tip of the month

UGH syndrome should be considered in every pseudophakic patient, with active unilateral inflammation and elevated intraocular pressure

Uveitis-Glaucoma-Hyphaema (UGH) Syndrome is a rare syndrome characterized by iris transillumination defects, microhyphaemas and pigmentary...

June 30, 2022

Intravenous hypertonic saline to reduce intraocular pressure: the effect of splitting the bolus

NGP Paper

Intravenous hypertonic saline to reduce intraocular pressure: the effect of splitting the bolus

Author(s): Pia Inborr (1), Mika Harju (1), Tero T Kivelä (1) 1 Department of Ophthalmology, University of Helsinki and Helsinki University...

June 30, 2022

Hypotony-related complications, not numerical hypotony, should alarm the clinician

Tip of the month

Hypotony-related complications, not numerical hypotony, should alarm the clinician

Chronic hypotony, defined as a pressure of ≤5 mmHg for >3 months, may occur after glaucoma surgery (1,2). Despite being traditionally regarded...

May 31, 2022

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial

Clinical paper of the month

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial

Author(s): Carlos Gustavo De Moraes (1), Simon W M John (1,2,3), Pete A Williams (4), Dana M Blumberg (1), George A Cioffi (1), Jeffrey M Liebmann...

May 31, 2022

Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion

Experimental Paper of the Month

Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion

Author(s): Lili Xie (1,2), Ling-Ping Cen (1,2 3), Yiqing Li (1,2,4), Hui-Ya Gilbert (1,2), Oleksandr Strelko (1,2), Cynthia Berlinicke (5,6,7,8),...

May 31, 2022

When choosing a glaucoma operation, be guided by the target intra-ocular pressure (IOP)

Tip of the month

When choosing a glaucoma operation, be guided by the target intra-ocular pressure (IOP)

In recent years, we have seen a vast expansion of incisional surgical techniques for glaucoma with a wide range of long-term efficacy and safety...

April 30, 2022

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Clinical paper of the month

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Author(s): Nathan Ingold (1,2), Adrian I Campos (1,3), Xikun Han (1,3), Jue-Sheng Ong (1), Puya Gharahkhani (1), David A Mackey (4), Miguel E...

April 30, 2022

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Experimental Paper of the Month

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Author(s): Nathan Ingold (1,2), Adrian I Campos (1,3), Xikun Han (1,3), Jue-Sheng Ong (1), Puya Gharahkhani (1), David A Mackey (4), Miguel E...

April 30, 2022