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  • Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

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    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate...

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  • A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

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    A foundation model for generalizable disease detection from retinal images

    A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health...

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  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

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    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation...

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  • Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

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    Beware of acute corneal oedema after SLT in selected patients

    Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT)...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Glaucoma Gel Implant Learning Curve in a Teaching Tertiary Hospital

NGP Paper

Glaucoma Gel Implant Learning Curve in a Teaching Tertiary Hospital

Author(s):* Raquel Esteves Marques (1,2), Nuno Pinto Ferreira (1,2), David Cordeiro Sousa (1,2,3), Joana Pinto (1,2), André Barata (1,2), Paula...

March 30, 2020

Glaucoma associated with retinal detachment

Pearl

Glaucoma associated with retinal detachment

Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...

March 30, 2020

Aniridia and Axenfeld-Rieger Syndrome: Clinical Presentations, Molecular Genetics and Current/Emerging Therapies

Clinical paper of the month

Aniridia and Axenfeld-Rieger Syndrome: Clinical Presentations, Molecular Genetics and Current/Emerging Therapies

Author(s): Paul W Chrystal (1), Michael A Walter (2) 1 Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada. 2 Department of...

February 29, 2020

Electrophysiology in Glaucoma

Experimental Paper of the Month

Electrophysiology in Glaucoma

Author(s): Senger C (1), Moreto R (1), Watanabe SES ()2, Matos AG (1), Paula JS (1) 1 Department of Ophthalmology, Otorhinolaryngology and Head and...

February 29, 2020

Consider Brinzolamide to prevent IOP Spikes after Cataract Surgery in Eyes with Glaucoma

Tip of the month

Consider Brinzolamide to prevent IOP Spikes after Cataract Surgery in Eyes with Glaucoma

The Science behind the Tip IOP spikes, i.e. an IOP elevation after surgery compared to baseline, often occur in eyes with glaucoma.2 IOP spikes may...

February 28, 2020

Visual Field Progression

Pearl

Visual Field Progression

Pearls Manager: Andrew Tatham Visual field progression analyses may be event or trend-based. Trend analyses quantify rate of progression, usually...

February 20, 2020

Next Generation Partnership SIG

SIG Corner

Next Generation Partnership SIG

SIG Corner Editor: João Barbosa Breda Chair: Gauti Jóhannesson Co-chairs: Esther Hoffmann, Francesco Oddone, Anthony Khawaja What is the NGP? The...

February 19, 2020

Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs

Clinical paper of the month

Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs

Author(s): Jammal AA (1), Thompson AC (2), Mariottoni EB (2), Berchuck SI (3), Urata CN (2), Estrela T (2), Wakil SM (2), Costa VP (4), Medeiros FA...

December 31, 2019

Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma

Experimental Paper of the Month

Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma

Author(s): Fischer RA (1), Risner ML (2,3), Roux AL (2), Wareham LK (2), Sappington RM (1,2,3) 1 Department of Pharmacology, Vanderbilt University,...

December 31, 2019

Intravenous Hypertonic Saline to Lower Intraocular Pressure in Ocular Hypertension and Primary Open-angle and Exfoliation Glaucoma

NGP Paper

Intravenous Hypertonic Saline to Lower Intraocular Pressure in Ocular Hypertension and Primary Open-angle and Exfoliation Glaucoma

Author(s): Pia Katriina Inborr (1), Mika Harju, Tero T Kivelä Department of Ophthalmology, Helsinki University Hospital and University of Helsinki,...

December 30, 2019

The Ocular Hypertension Treatment Study (OHTS)

Pearl

The Ocular Hypertension Treatment Study (OHTS)

Pearls Manager: Andrew Tatham The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...

December 20, 2019

How should we define target intraocular pressure?

Pearl

How should we define target intraocular pressure?

Pearls Manager: Andrew Tatham Target IOP is the upper limit of IOP estimated to be compatible with a rate of progression sufficiently slow to...

December 02, 2019

Glaucoma management in the era of artificial intelligence

Clinical paper of the month

Glaucoma management in the era of artificial intelligence

Author(s): Devalla SK (1), Liang Z (1), Pham TH (1,2), Boote C (1,3,4), Strouthidis NG (2,5,6), Thiery AH (7), Girard MJA (8,2) 1 Department of...

November 30, 2019

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Experimental Paper of the Month

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Author(s): Khatib TZ (1,2,3), Martin KR (1,2,4,5,6,7) 1 John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of...

November 30, 2019

Glaucoma following childhood cataract surgery

Pearl

Glaucoma following childhood cataract surgery

Pearls Manager: Andrew Tatham Secondary glaucoma is a frequent serious complication after cataract surgery in early infancy. The incidence may...

November 30, 2019

Consider using a topical NSAID, or steroid, post SLT laser

Tip of the month

Consider using a topical NSAID, or steroid, post SLT laser

The Science behind the Tip There is widespread variation in post laser treatment regimes. In a recent randomized, double-masked, multi-center...

October 31, 2019

Exogenous influences on intraocular pressure

Clinical paper of the month

Exogenous influences on intraocular pressure

Author(s): Kim YW (1), Park KH (2) 1 Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. 2 Ophthalmology, Seoul National...

October 31, 2019

Cholinergic nervous system and glaucoma: From basic science to clinical applications

Experimental Paper of the Month

Cholinergic nervous system and glaucoma: From basic science to clinical applications

Author(s): Faiq MA (1), Wollstein G (1), Schuman JS (1), Chan KC (2) 1 Department of Ophthalmology, New York University (NYU) School of Medicine,...

October 31, 2019

Ocular Blood Flow SIG

SIG Corner

Ocular Blood Flow SIG

SIG Corner Editor: João Barbosa Breda Chair: Leopold Schmetterer Co-chair: Luis Abegão Pinto 1. Ongoing projects The Ocular Blood Flow SIG and its...

October 24, 2019

Gonioscopy is essential for evaluating patients with a suspected or confirmed diagnosis of glaucoma

Pearl

Gonioscopy is essential for evaluating patients with a suspected or confirmed diagnosis of glaucoma

Pearls Manager: Andrew Tatham The corneal wedge method is helpful for identifying Schwalbe’s line, a collagen condensation of the Descemet’s...

October 22, 2019

Consider additional 10-2 visual field testing for diagnosing glaucoma, as limiting to 24-2 or 30-2 tests will frequently miss or underestimate paracentral field defects

Tip of the month

Consider additional 10-2 visual field testing for diagnosing glaucoma, as limiting to 24-2 or 30-2 tests will frequently miss or underestimate paracentral field defects

The Science behind the Tip (1,2) It is well-established that damage to macular retinal ganglion cells (RGCs) occurs early in glaucoma (1). Not...

September 30, 2019

Predictors of Neovascular Glaucoma in Central Retinal Vein Occlusion

Clinical paper of the month

Predictors of Neovascular Glaucoma in Central Retinal Vein Occlusion

Author(s): Rong AJ (1), Swaminathan SS (2), Vanner EA (3), Parrish RK 2nd (3) 1 Department of Ophthalmology, Bascom Palmer Eye Institute,...

September 30, 2019

microRNA dysregulation in neurodegenerative diseases: A systematic review

Experimental Paper of the Month

microRNA dysregulation in neurodegenerative diseases: A systematic review

Author(s): Juźwik CA (1), Sage-Drake S (2), Zhang Y (3), Paradis-Isler N (4), Sylvester A (5), Amar-Zifkin A (6), Douglas C (7), Morquette B (8),...

September 30, 2019