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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial

Clinical paper of the month

Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial

Author(s): Gazzard G (1), Konstantakopoulou E (2), Garway-Heath D (2), Garg A (2), Vickerstaff V (3), Hunter R (4), Ambler G (5), Bunce C (6),...

April 30, 2019

Border Tissue Morphology is Spatially Associated with Focal Lamina Cribrosa Defect and Deep-Layer Microvasculature Dropout in Open-Angle Glaucoma

Experimental Paper of the Month

Border Tissue Morphology is Spatially Associated with Focal Lamina Cribrosa Defect and Deep-Layer Microvasculature Dropout in Open-Angle Glaucoma

Author(s): Han JC (1), Choi JH (1), Park DY (1), Lee EJ (1), Kee C (2) 1 Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan...

April 30, 2019

Management of glaucoma during pregnancy

Pearl

Management of glaucoma during pregnancy

Pearls Manager: Andrew Tatham Women with glaucoma of child bearing age should be informed about the possible need to modify treatment during...

April 30, 2019

Imaging SIG

SIG Corner

Imaging SIG

SIG Corner Editor: João Barbosa Breda Chair: Hans LemijCo-chair: David Garway-Heath 1. Goals and Activities of the SIG The Imaging SIG’s main...

April 01, 2019

Ocular coherence tomography (OCT) should be used cautiously in the context of uveitic glaucoma

Tip of the month

Ocular coherence tomography (OCT) should be used cautiously in the context of uveitic glaucoma

The Science behind the Tip Patients with uveitis have a heightened risk of developing secondary glaucoma. Ocular Coherence Tomography (OCT) imaging...

March 31, 2019

Visual Crowding in Glaucoma

Clinical paper of the month

Visual Crowding in Glaucoma

Author(s): Ogata NG (1), Boer ER (2), Daga FB (1), Jammal AA (1), Stringham JM (1), Medeiros FA (1) 1 Duke Eye Center, Department of Ophthalmology,...

March 31, 2019

Artificial intelligence and deep learning in ophthalmology

Experimental Paper of the Month

Artificial intelligence and deep learning in ophthalmology

Author(s): Ting DSW (1), Pasquale LR (2), Peng L (3), Campbell JP (4), Lee AY (5), Raman R (6), Tan GSW (7), Schmetterer L (7,8,9,10), Keane PA...

March 31, 2019

Pigmentary glaucoma

Pearl

Pigmentary glaucoma

Pearls Manager: Andrew Tatham Pigmentary glaucoma represents 1 to 1.5% of all glaucoma cases. It is more common in Caucasian myopic men and is...

March 30, 2019

Depression may follow a diagnosis of chronic glaucoma, but depressive symptoms are less likely to be present one year later

Tip of the month

Depression may follow a diagnosis of chronic glaucoma, but depressive symptoms are less likely to be present one year later

The Science behind the Tip It is common for a newly-diagnosed patient with glaucoma to experience symptoms of depression (1,2). Patients who are...

March 01, 2019

The Effects of Optic Nerve Head Tilt on Visual Field Defects in Myopic Normal Tension Glaucoma: The Inter-eye Comparison Study

Clinical paper of the month

The Effects of Optic Nerve Head Tilt on Visual Field Defects in Myopic Normal Tension Glaucoma: The Inter-eye Comparison Study

Author(s): Choi JH (1), Han JC, Kee C 1 Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,...

February 28, 2019

Identification of Candidate miRNA Biomarkers for Glaucoma

Experimental Paper of the Month

Identification of Candidate miRNA Biomarkers for Glaucoma

Author(s): Hindle AG1, Thoonen R2, Jasien JV (3), Grange RMH (1), Amin K (4), Wise J (4), Ozaki M (5), Ritch R (3), Malhotra R (2), Buys ES (1) 1...

February 28, 2019

Care Delivery SIG

SIG Corner

Care Delivery SIG

SIG Corner Editor: João Barbosa Breda Chair: Anton B. Hommer Co-chair: Gabor Holló Update on ongoing projects The goal of this SIG is to get a...

February 28, 2019

How to perform Goldmann applanation tonometry in patients with significant regular corneal astigmatism

Pearl

How to perform Goldmann applanation tonometry in patients with significant regular corneal astigmatism

Pearls Manager: Andrew Tatham When performing Goldmann applanation tonometry in patients with significant regular corneal astigmatism (>3...

February 20, 2019

Early bleb revision usually results in successful resolution of hypotony maculopathy after trabeculectomy with mitomycin C

Tip of the month

Early bleb revision usually results in successful resolution of hypotony maculopathy after trabeculectomy with mitomycin C

The Science behind the Tip Hypotony maculopathy is characterized by painless loss of vision usually more than three months after glaucoma...

January 31, 2019

Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review

Clinical paper of the month

Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review

Author(s): Patel P (1), Harris A (1), Toris C (2), Tobe L (1), Lang M (1), Belamkar A (1), Ng A (1), Verticchio Vercellin AC (3,4), Mathew S (1),...

January 31, 2019

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Experimental Paper of the Month

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Author(s): Mathieu E (1,2,3), Gupta N (1,2,3,4,5), Paczka-Giorgi LA (1,2), Zhou X (1,2), Ahari A (1,2), Lani R (1), Hanna J (1,2,3), Yücel YH...

January 31, 2019

Next Generation Partnership SIG

SIG Corner

Next Generation Partnership SIG

IG Corner Editor: João Barbosa Breda Chair: Gauti Jóhannesson Co-chairs: Esther Hoffmann, Francesco Oddone, Anthony Khawaja 1. Update on ongoing...

January 24, 2019

Children using topical corticosteroids for the treatment of allergic conjunctivitis must have their intraocular pressure regularly checked

Tip of the month

Children using topical corticosteroids for the treatment of allergic conjunctivitis must have their intraocular pressure regularly checked

The Science behind the Tip 30-40% of the population respond to topical steroids by increasing their IOP (1). A steroid response is commonly found...

December 31, 2018

Artificial intelligence and deep learning in ophthalmology

Clinical paper of the month

Artificial intelligence and deep learning in ophthalmology

Author(s): Ting DSW (1), Pasquale LR (2), Peng L (3), Campbell JP (4), Lee AY (5), Raman R (6), Tan GSW (7), Schmetterer L (7,8,9,10), Keane PA...

December 31, 2018

Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review

Experimental Paper of the Month

Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review

Author(s): Sabel BA (1), Flammer J (2), Merabet LB (3) 1 Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University of...

December 31, 2018

Exfoliative glaucoma is the most common type of secondary open angle glaucoma

Pearl

Exfoliative glaucoma is the most common type of secondary open angle glaucoma

Pearls Manager: Andrew Tatham It develops in approximately 15 to 26% of eyes with exfoliation syndrome within 5 years and frequently causes severe...

December 30, 2018

The results of trabeculectomy with mitomycin C are significantly improved in children with glaucoma secondary to juvenile idiopathic arthritis if they are on immune-modulatory treatment

Tip of the month

The results of trabeculectomy with mitomycin C are significantly improved in children with glaucoma secondary to juvenile idiopathic arthritis if they are on immune-modulatory treatment

The Science behind the Tip Juvenile idiopathic arthritis (JIA) is the most common systemic disease associated with childhood anterior uveitis....

November 30, 2018

Familial Risks of Glaucoma in the Population of Sweden

Clinical paper of the month

Familial Risks of Glaucoma in the Population of Sweden

Author(s): Li X (1), Sundquist J (1,2,3), Zöller B (1), Sundquist K (1,2,3) 1 Center for Primary Health Care Research, Lund University, Sweden. 2...

November 30, 2018

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Experimental Paper of the Month

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Author(s): Singh LN (1), Crowston JG (2), Lopez Sanchez MIG (2), Van Bergen NJ (2), Kearns LS (2), Hewitt AW (2,3), Yazar S (4,5), Mackey DA (4),...

November 30, 2018

Do you know how to stage an angle closure?

Pearl

Do you know how to stage an angle closure?

Pearls Manager: Andrew Tatham Primary Angle-Closure Suspect (PACS) - Two or more quadrants of iridotrabecular contact (lTC), normal IOP, no PAS, no...

November 23, 2018