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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Microperimetry may be a more sensitive method of detecting a small glaucomatous defect close to fixation, than standard automated perimetry and OCT analysis of the retinal nerve fibre layer (RNFL)

Tip of the month

Microperimetry may be a more sensitive method of detecting a small glaucomatous defect close to fixation, than standard automated perimetry and OCT analysis of the retinal nerve fibre layer (RNFL)

The Science behind the Tip Microperimetry is a form of fundus-tracking perimetry that can detect reduced retinal sensitivity close to fixation more...

October 31, 2018

The Magnitude of IOP Elevation Associated with Eye Rubbing

Clinical paper of the month

The Magnitude of IOP Elevation Associated with Eye Rubbing

Author(s): Turner DC (1), Girkin CA (2), Downs JC (3) 1 Department of Vision Sciences, School of Optometry, University of Alabama at Birmingham,...

October 31, 2018

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

Experimental Paper of the Month

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

Author(s): Bosco A(1), Anderson SR(2), Breen KT(2), Romero CO(2), Steele MR(2), Chiodo VA(3), Boye SL(3), Hauswirth WW(3), Tomlinson S(4), Vetter...

October 31, 2018

When to perform a prophylactic iridotomy?

Pearl

When to perform a prophylactic iridotomy?

Pearls Manager: Andrew Tatham An international group of experts reached a consensus that 2 quadrants or more of ITC is an indication for...

October 22, 2018

A glaucoma drainage device may be more effective than trabeculectomy in lowering IOP after keratoplasty, but is more likely to result in graft failure

Tip of the month

A glaucoma drainage device may be more effective than trabeculectomy in lowering IOP after keratoplasty, but is more likely to result in graft failure

The Science behind the Tip A well-controlled intraocular pressure (IOP) after penetrating keratoplasty (PK) is essential for graft survival and to...

September 30, 2018

Structural reversal of disc cupping after trabeculectomy alters Bruch's membrane opening-based parameters to assess neuroretinal rim

Clinical paper of the month

Structural reversal of disc cupping after trabeculectomy alters Bruch's membrane opening-based parameters to assess neuroretinal rim

Author(s): Gietzelt C (1), Lemke J (1), Schaub F (1), Hermann MM (1), Dietlein TS (1), Cursiefen C (1), Enders P (2), Heindl LM (1) 1 Department of...

September 30, 2018

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

Experimental Paper of the Month

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

Author(s): MacGregor S (1), Ong JS (2), An J (2), Han X (2), Zhou T (3), Siggs OM (3), Law MH (2), Souzeau E (3), Sharma S (3), Lynn DJ (4,5,6),...

September 30, 2018

Tolerable rates of visual field progression in a population-based sample of patients with glaucoma

Clinical paper of the month

Tolerable rates of visual field progression in a population-based sample of patients with glaucoma

Author(s): Salonikiou A (1), Founti P (1,2), Kilintzis V (1), Antoniadis A (1), Anastasopoulos E (1), Pappas T (1), Raptou A (1), Topouzis F (1) 1...

July 31, 2018

Nogo-A inactivation improves visual plasticity and recovery after retinal injury

Experimental Paper of the Month

Nogo-A inactivation improves visual plasticity and recovery after retinal injury

Author(s): Mdzomba JB (1), Jordi N (2), Rodriguez L (1), Joly S (1), Bretzner F (3), Pernet V (4) 1 CUO-Recherche, Centre de recherche du CHU de...

July 31, 2018

When determining a therapeutic approach to a patient with glaucoma, the life expectancy of the patient needs to be considered

Tip of the month

When determining a therapeutic approach to a patient with glaucoma, the life expectancy of the patient needs to be considered

The Science behind the Tip Patients who present with early glaucoma who have a short life expectancy are unlikely to go blind from glaucoma in...

June 30, 2018

Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients

Clinical paper of the month

Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients

Author(s): Hou H (1), Shoji T (2), Zangwill LM (1), Moghimi S (3), Saunders LJ (1), Hasenstab K (1), Ghahari E (1), Manalastas PIC (1), Akagi T...

June 30, 2018

Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects

Experimental Paper of the Month

Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects

Author(s): Chitranshi N (1), Dheer Y (1), Abbasi M (1), You Y (2), Graham SL (1), Gupta V (1) 1 Faculty of Medicine and Health Sciences, Macquarie...

June 30, 2018

The insertion of a punctal plug improves ocular comfort and results in a modest reduction of IOP in patients with glaucoma who are using topical medication

Tip of the month

The insertion of a punctal plug improves ocular comfort and results in a modest reduction of IOP in patients with glaucoma who are using topical medication

The Science behind the Tip Patients with ocular hypertension and chronic glaucoma have a higher prevalence of ocular surface disease (OSD) than...

May 31, 2018

What have we learned about exfoliation syndrome since its discovery by John Lindberg 100 years ago?

Clinical paper of the month

What have we learned about exfoliation syndrome since its discovery by John Lindberg 100 years ago?

Author(s): Nazarali S (1), Damji F (2), Damji KF (3) 1 Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. 2 School of Kinesiology,...

May 31, 2018

The coma in glaucoma: Retinal ganglion cell dysfunction and recovery

Experimental Paper of the Month

The coma in glaucoma: Retinal ganglion cell dysfunction and recovery

Author(s): Fry LE (1), Fahy E (2), Chrysostomou V (3), Hui F (2), Tang J (2), van Wijngaarden P (2), Petrou S (4), Crowston JG (5) 1 Centre for Eye...

May 31, 2018

In a patient with pigment dispersion syndrome, the most significant ocular risk factor for conversion to glaucoma is an IOP above 21mmHg on presentation

Tip of the month

In a patient with pigment dispersion syndrome, the most significant ocular risk factor for conversion to glaucoma is an IOP above 21mmHg on presentation

The Science behind the Tip Pigment dispersion syndrome tends to occur in young myopic white men. There are genetic factors that underly the risk...

April 30, 2018

Twenty-year outcomes in patients with newly diagnosed glaucoma: mortality and visual function

Clinical paper of the month

Twenty-year outcomes in patients with newly diagnosed glaucoma: mortality and visual function

Author(s): King C (1), Sherwin JC (1), Ratnarajan G (2), Salmon JF (1) 1 Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust,...

April 30, 2018

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma

Experimental Paper of the Month

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma

Author(s): Huard DJE (1), Crowley VM (2), Du Y (3), Cordova RA (4), Sun Z (4), Tomlin MO (1), Dickey CA (4), Koren J 3rd (4), Blair L (4), Fu H...

April 30, 2018

Validated prediction models are helpful to determine the risk of an individual with ocular hypertension developing chronic glaucoma

Tip of the month

Validated prediction models are helpful to determine the risk of an individual with ocular hypertension developing chronic glaucoma

The Science behind the Tip Raised intraocular pressure (IOP) is an important risk factor for the development of glaucoma and can be modified with...

March 31, 2018

Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health

Clinical paper of the month

Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health

Author(s): Zhu MM (1), Lai JSM (1), Choy BNK (1), Shum JWH (1), Lo ACY (1), Ng ALK (1), Chan JCH (1), So KF (1,2,3,4) 1 Department of...

March 31, 2018

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Experimental Paper of the Month

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Author(s): Gharahkhani P (1), Burdon KP (2), Cooke Bailey JN (3), Hewitt AW (2), Law MH (4), Pasquale LR (5), (6), Kang JH (6), Haines JL (3),...

March 31, 2018

Measuring the intraocular pressure (IOP) not only in sitting, but also in supine position, may help to identify the 24-hour IOP characteristics of your glaucoma patient

Tip of the month

Measuring the intraocular pressure (IOP) not only in sitting, but also in supine position, may help to identify the 24-hour IOP characteristics of your glaucoma patient

The Science behind the Tip It is well known that each patient has an individual circadian IOP pattern. Studies have shown that up to two thirds of...

February 28, 2018

The Iridocorneal Endothelial Syndrome

Clinical paper of the month

The Iridocorneal Endothelial Syndrome

Author(s): Silva L (1), Najafi A (2), Suwan Y (3), Teekhasaenee C (4), Ritch R (2) 1 Einhorn Clinical Research Center, The New York Eye and Ear...

February 28, 2018

Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma

Experimental Paper of the Month

Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma

Author(s): Chou TH (1), Musada GR (2), Romano GL (3), Bolton E (4), Porciatti V (5) 1 Bascom Palmer Eye Institute, University of Miami Miller...

February 28, 2018

Treatment of ischaemic central retinal vein occlusion with prophylactic anti-VEGF injections reduces the risk of neovascular glaucoma, but careful long-term monitoring for ocular new vessels remains essential

Tip of the month

Treatment of ischaemic central retinal vein occlusion with prophylactic anti-VEGF injections reduces the risk of neovascular glaucoma, but careful long-term monitoring for ocular new vessels remains essential

The Science behind the Tip Approximately 20% of central retinal vein occlusions (CRVO) are ischaemic and of those, 45% develop neovascular...

January 31, 2018