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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Detecting Visual Field Progression

Clinical paper of the month

Detecting Visual Field Progression

Author(s): Aref AA (1), Budenz DL (2) 1 Illinois Eye & Ear Infirmary, University of Illinois at Chicago College of Medicine, Chicago, Illinois....

January 31, 2018

ASK1 in neurodegeneration

Experimental Paper of the Month

ASK1 in neurodegeneration

Author(s): Guo X (1), Namekata K (2), Kimura A (2), Harada C (2), Harada T (2) 1 Visual Research Project, Tokyo Metropolitan Institute of Medical...

January 31, 2018

OCT measurement of the retinal nerve fibre layer is useful for detecting progression in early glaucoma

Tip of the month

OCT measurement of the retinal nerve fibre layer is useful for detecting progression in early glaucoma

The Science behind the Tip Both visual field testing and optical coherence tomography (OCT) measurements can be used to detect glaucomatous...

December 31, 2017

Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects

Clinical paper of the month

Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects

Author(s): Sawada Y (1), Araie M (2), Ishikawa M (3), Yoshitomi T (3) 1 Department of Ophthalmology, Akita University Graduate School of Medicine,...

December 31, 2017

Bleb encapsulation after trabeculectomy can be successfully treated by using aqueous suppressant treatment for a short period

Tip of the month

Bleb encapsulation after trabeculectomy can be successfully treated by using aqueous suppressant treatment for a short period

The Science behind the Tip Bleb encapsulation may occur 2 to 6 weeks after trabeculectomy, when an elevated, tense, dome-shaped bleb develops with...

November 30, 2017

Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma

Clinical paper of the month

Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma

Author(s): Akagi T (1), Zangwill LM (2), Saunders LJ (2), Yarmohammadi A (2), Manalastas PIC (2), Suh MH (3), Girkin CA (4), Liebmann JM (5),...

November 30, 2017

Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA

Experimental Paper of the Month

Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA

Author(s): Takahama S (1), Adetunji MO (1), Zhao T (2), Chen S2, Li W (2), Tomarev SI (1) 1 Section on Retinal Ganglion Cell Biology, Laboratory of...

November 30, 2017

A patient who presents with raised intraocular pressure or glaucoma and distended episcleral veins in one eye needs to be investigated for a spontaneous carotid – cavernous fistula

Tip of the month

A patient who presents with raised intraocular pressure or glaucoma and distended episcleral veins in one eye needs to be investigated for a spontaneous carotid – cavernous fistula

The Science behind the Tip A carotid – cavernous sinus fistula is an abnormal vascular communication between the carotid artery system and the...

October 31, 2017

Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG)

Experimental Paper of the Month

Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG)

Author(s): Schmelter C (1), Perumal N (1), Funke S (1), Bell K (1), Pfeiffer N (1), Grus FH (1) 1 Department of Experimental and Translational...

October 31, 2017

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis

Clinical paper of the month

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis

Author(s): Aschard H (1), Kang JH (2), Iglesias AI (3), Hysi P (4), Cooke Bailey JN (5,6), Khawaja AP (7), Allingham RR (8), Ashley-Koch A (9), Lee...

October 31, 2017

Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes

Experimental Paper of the Month

Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes

Author(s): Van Houcke J (1), Bollaerts I (1), Geeraerts E (1), Davis B (2), Beckers A (1), Van Hove I (1), Lemmens K (1), De Groef L (3), Moons L...

October 31, 2017

Glaucoma associated with congenital aniridia is difficult to treat, but tube-shunt drainage devices offer the best results

Tip of the month

Glaucoma associated with congenital aniridia is difficult to treat, but tube-shunt drainage devices offer the best results

The Science behind the Tip Congenital aniridia is a rare bilateral developmental disorder which is inherited in an autosomal dominant fashion in...

September 30, 2017

Rates of glaucomatous visual field change after trabeculectomy

Clinical paper of the month

Rates of glaucomatous visual field change after trabeculectomy

Author(s): Baril C (1), Vianna JR (1), Shuba LM (1), Rafuse PE (1), Chauhan BC (1), Nicolela MT (1) 1 Department of Ophthalmology and Visual...

September 30, 2017

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Experimental Paper of the Month

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...

September 30, 2017

In a young patient with acute congestive angle closure or recurrent angle closure in the presence of a patent laser iridotomy, the underlying cause is usually plateau iris configuration

Tip of the month

In a young patient with acute congestive angle closure or recurrent angle closure in the presence of a patent laser iridotomy, the underlying cause is usually plateau iris configuration

The Science behind the Tip Plateau iris configuration is characterised by a closed anterior chamber angle in association with a flat iris plane and...

July 31, 2017

Risk Factors for Rapid Glaucoma Disease Progression

Clinical paper of the month

Risk Factors for Rapid Glaucoma Disease Progression

Author(s): Chan TCW (1), Bala C (2), Siu A (3), Wan F (3), White A (4) 1 University of Sydney, Sydney, Australia. 2 Macquarie University, Sydney,...

July 31, 2017

Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss

Experimental Paper of the Month

Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss

Author(s): 1 Neuroscience Graduate Program, Vanderbilt UniversityNashville, TN, United States. 2 Department of Ophthalmology and Visual Sciences,...

July 31, 2017

The chronic use of prostaglandin analogues may lead to a modest underestimation of IOP when measured by Goldmann applanation tonometry

Tip of the month

The chronic use of prostaglandin analogues may lead to a modest underestimation of IOP when measured by Goldmann applanation tonometry

The Science behind the Tip Corneal hysteresis is a biomechanical property of the cornea relating to its elasticity. The measurement of corneal...

June 30, 2017

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Clinical paper of the month

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...

June 30, 2017

Regulation of intraocular pressure by microRNA cluster miR-143/145

Experimental Paper of the Month

Regulation of intraocular pressure by microRNA cluster miR-143/145

Author(s): Li X (1,2), Zhao F (3,4), Xin M (5), Li G (6), Luna C (6), Li G (1), Zhou Q (4), He Y (2), Yu B (4), Olson E (7), Gonzalez P (6), Wang S...

June 30, 2017

In a patient with glaucoma who has unexplained hair loss, stop topical beta-blocker treatment

Tip of the month

In a patient with glaucoma who has unexplained hair loss, stop topical beta-blocker treatment

The Science behind the Tip Beta adrenergic receptor blocking eye drops are often used to reduce the intraocular pressure. Because of absorption...

May 31, 2017

Neuroprotection for glaucoma: Requirements for clinical translation

Clinical paper of the month

Neuroprotection for glaucoma: Requirements for clinical translation

Author(s): Levin LA (1), Crowe ME (2), Quigley HA (3); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants 1...

May 31, 2017

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Experimental Paper of the Month

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Author(s): Zhu W (1), Jain A (2), Gramlich OW (3), Tucker BA (3), Sheffield VC (4), Kuehn MH (1) 1 Department of Ophthalmology and Visual Sciences,...

May 31, 2017

Patients with normal tension glaucoma who develop a branch retinal vein occlusion should be monitored with greater care

Tip of the month

Patients with normal tension glaucoma who develop a branch retinal vein occlusion should be monitored with greater care

The Science behind the Tip If a branch retinal vein occlusion (BRVO) occurs in a patient with normal tension glaucoma, it tends to occur in the eye...

April 30, 2017

Visual function may improve after trabeculectomy in some adults with moderately advanced glaucoma

Tip of the month

Visual function may improve after trabeculectomy in some adults with moderately advanced glaucoma

The Science behind the Tip We were taught that visual field loss from glaucoma is irreversible and that our interventions could at best, preserve...

March 31, 2017