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  • TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

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    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

    Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...

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  • Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

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    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

    Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...

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  • Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

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    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

    The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Optical coherence tomography for glaucoma diagnosis

Pearl

Optical coherence tomography for glaucoma diagnosis

Pearls Manager: Andrew Tatham Optical coherence tomography (OCT) on its own does not provide a clinical diagnosis of glaucoma, just a statistical...

December 30, 2020

Trabecular meshwork bypass surgery should be avoided if high episcleral venous pressure is suspected

Tip of the month

Trabecular meshwork bypass surgery should be avoided if high episcleral venous pressure is suspected

The intraocular pressure lowering effect of procedures that attempt to enhance flow of aqueous into Schlemm’s canal by bypassing or cutting the...

November 30, 2020

Neuroprotection SIG

SIG Corner

Neuroprotection SIG

SIG Corner Editor: João Barbosa Breda Chair: Francesca Cordeiro Co-chair: Miriam Kolko The goal of this SIG is to increase ophthalmologists’...

November 30, 2020

Minimally invasive and micro incisional glaucoma surgery

Pearl

Minimally invasive and micro incisional glaucoma surgery

Pearls Manager: Andrew Tatham Surgical procedures that entail less tissue manipulation with the expectation of a better safety profile and quicker...

November 30, 2020

Haemodialysis can cause an acute rise in intraocular pressure

Tip of the month

Haemodialysis can cause an acute rise in intraocular pressure

Haemodialysis (HD) can reportedly induce a sudden rise in intraocular pressure (IOP) in patients with neovascular (NVG) (1) and pseudo-exfoliative...

October 31, 2020

Longitudinal Macular Ganglion Cell-Inner Plexiform Layer Measurements to Detect Glaucoma Progression in High Myopia

Clinical paper of the month

Longitudinal Macular Ganglion Cell-Inner Plexiform Layer Measurements to Detect Glaucoma Progression in High Myopia

Author(s): Joong Won Shin (1), Min Kyung Song (1), Kyung Rim Sung (2) 1 Department of Ophthalmology, College of Medicine, University of Ulsan, Asan...

October 31, 2020

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases

Experimental Paper of the Month

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases

Author(s): Bryn L Brazile (1), Bin Yang (1,2), Susannah Waxman (1) , Po Lam (1), Andrew P Voorhees (1), Yi Hua (1), Ralitsa T Loewen (1), Nils A...

October 31, 2020

Malignant glaucoma

Pearl

Malignant glaucoma

Pearls Manager: Andrew Tatham Malignant glaucoma or aqueous misdirection is a rare type of secondary angle closure glaucoma most commonly...

October 20, 2020

Angle Closure - Relevant breakthroughs in this field

SIG Corner

Angle Closure - Relevant breakthroughs in this field

2.1 Should laser peripheral iridotomy (LPI) be performed in primary angle-closure suspect (PACS) patients? Last year we covered the EAGLE and ZAP...

October 01, 2020

Glaucoma progression: watch out the fellow, non-progressing eye

Tip of the month

Glaucoma progression: watch out the fellow, non-progressing eye

In clinical practice, the detection of visual field progression in one eye usually leads to management modifications in that eye. Less attention is...

September 30, 2020

Cardiovascular Disease may predict structural and functional progression in early glaucoma

Clinical paper of the month

Cardiovascular Disease may predict structural and functional progression in early glaucoma

Author(s): Henry Marshall (1), Sean Mullany (2), Ayub Qassim (2), Mark Hassall (2), Owen Siggs (2), Bronwyn Ridge (2), Thi Nguyen (2), Mona...

September 30, 2020

Association of Glaucoma Risk Genes with Retinal Nerve Fiber Layer in a Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study

Experimental Paper of the Month

Association of Glaucoma Risk Genes with Retinal Nerve Fiber Layer in a Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study

Author(s): Xiaoran Chai (1,2,3), Kok Yao Low (1,4), Yih Chung Tham (1), Miao Li Chee (1), Sahil Thakur (1), Liang Zhang (1), Nicholas Y Tan (1),...

September 30, 2020

Mutations in SPATA13/ASEF2 Cause Primary Angle Closure Glaucoma

NGP Paper

Mutations in SPATA13/ASEF2 Cause Primary Angle Closure Glaucoma

Author(s): Naushin H Waseem (1), Sancy Low (2,3,4), Amna Z Shah (3), Deepa Avisetti (5), Pia Ostergaard (6), Michael Simpson (7), Katarzyna A...

September 30, 2020

Optimising eye drop instillation

Pearl

Optimising eye drop instillation

Pearls Manager: Andrew Tatham When two eye drops are instilled 30 seconds apart, almost 50% of the first drug will be washed out. It is recommended...

September 30, 2020

Take care not to miss glaucomatous cupping in patients with small discs!

Tip of the month

Take care not to miss glaucomatous cupping in patients with small discs!

The Science behind the Tip The diagnosis of glaucoma can be missed in patients with small optic discs (1). In such patients, relative crowding of...

July 31, 2020

Longitudinal Macular Structure–Function Relationships in Glaucoma

Clinical paper of the month

Longitudinal Macular Structure–Function Relationships in Glaucoma

Author(s): Vahid Mohammadzadeh (1), Alessandro Rabiolo (2), Qiang Fu (3), Esteban Morales (1), Anne L Coleman (1), Simon K Law (1), Joseph Caprioli...

July 31, 2020

Efficacy for Differentiating Nonglaucomatous Versus Glaucomatous Optic Neuropathy Using Deep Learning Systems

Experimental Paper of the Month

Efficacy for Differentiating Nonglaucomatous Versus Glaucomatous Optic Neuropathy Using Deep Learning Systems

Author(s): Hee Kyung Yang (1), Young Jae Kim (2), Jae Yun Sung (1), Dong Hyun Kim (1), Kwang Gi Kim (3), Jeong-Min Hwang (4) 1 Department of...

July 31, 2020

The Collaborative Normal Tension Glaucoma Study (CNTGS)

Pearl

The Collaborative Normal Tension Glaucoma Study (CNTGS)

Pearls Manager: Andrew Tatham The CNTGS compared treatment versus no treatment in patients with normal tension glaucoma who had verified...

July 30, 2020

Ask your glaucoma patients about mobility rather than vision

Tip of the month

Ask your glaucoma patients about mobility rather than vision

The Science behind the Tip Self-reported visual disability in glaucoma which correlates with level of visual field loss includes bumping into...

June 30, 2020

Visual Field Outcomes from the Multicenter, Randomized Controlled Laser in Glaucoma and Ocular Hypertension Trial

Clinical paper of the month

Visual Field Outcomes from the Multicenter, Randomized Controlled Laser in Glaucoma and Ocular Hypertension Trial

Author(s): David M.Wright (1,2), Evgenia Konstantakopoulou (3,4,5), Giovanni Montesano (6), Neil Nathwani (3), Anurag Garg (3), David Garway-Heath...

June 30, 2020

Using Deep Learning to Automate Goldmann Applanation Tonometry Readings

Experimental Paper of the Month

Using Deep Learning to Automate Goldmann Applanation Tonometry Readings

Author(s): Ted Spaide (1), Yue Wu (1), Ryan T Yanagihara (1), Shu Feng (1), Omar Ghabra (1), Jonathan S Yi (1), Philip P Chen (1), Francy Moses...

June 30, 2020

Wound healing is one of the main determinants of long-term intraocular pressure control after filtering surgery

Pearl

Wound healing is one of the main determinants of long-term intraocular pressure control after filtering surgery

Pearls Manager: Andrew Tatham Risk factors for conjunctival scarring include young age, African ancestry, inflammatory eye disease, long-term...

June 18, 2020

Glaucoma patients on topical treatment should be routinely checked for signs of ocular surface disease even if they are asymptomatic

Tip of the month

Glaucoma patients on topical treatment should be routinely checked for signs of ocular surface disease even if they are asymptomatic

The Science behind the Tip The prevalence of ocular surface disease is significantly higher in glaucoma patients (1). While generally accepted that...

May 31, 2020

Franz Fankhauser: the father of the automated perimeter

Clinical paper of the month

Franz Fankhauser: the father of the automated perimeter

Author(s): Gloor BP Zürich, Switzerland. Franz Fankhauser is known as the father of automated perimetry and of the q-switched Nd:YAG laser knife....

May 31, 2020

Circadian Regulation of IOP Rhythm by Dual Pathways of Glucocorticoids and the Sympathetic Nervous System

Experimental Paper of the Month

Circadian Regulation of IOP Rhythm by Dual Pathways of Glucocorticoids and the Sympathetic Nervous System

Author(s): Ikegami K, Shigeyoshi Y, Masubuchi S PURPOSE: Elevated IOP can cause the development of glaucoma. The circadian rhythm of IOP depends on...

May 31, 2020