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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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The Pathogenesis of Raised Intraocular Pressure in Uveitis
Author(s): Baneke AJ (1), Lim KS (1), Stanford M (1) 1 a Department of Ophthalmology , St Thomas' Hospital, Guy's and St Thomas' NHS Trust , London...
April 30, 2016
Transplanted neurons integrate into adult retinas and respond to light
Author(s): Venugopalan P (1,2), Wang Y (2), Nguyen T (2), Huang A (2), Muller KJ (1,3), Goldberg JL (1,2,4) 1 Neuroscience Program, University of...
April 30, 2016
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Beware of the patient who presents with acute angle closure and transient myopia, as this may occur as an idiosyncratic side effect of oral sulfonamides
The science behind the tip The normal mechanism of angle closure is pupillary block, which is treated with a laser peripheral iridotomy (PI)....
March 31, 2016
Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes
Author(s): Hammel N (1), Belghith A (1), Bowd C (1), Medeiros FA (1), Sharpsten L (1), Mendoza N (1), Tatham AJ (1), Khachatryan N (1), Liebmann JM...
March 31, 2016
Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model
Author(s): Noristani R (1), Kuehn S (1), Stute G (1), Reinehr S (1), Stellbogen M (1), Dick HB (1), Joachim SC (2) 1 Experimental Eye Research...
March 31, 2016
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If a choroidal effusion develops after surgery in a patient with nanophthalmos then a partial thickness lamellar sclerectomy is an effective therapeutic option
The science behind the tip Raised IOP and secondary glaucoma are common late consequences of nanophthalmos (axial length less than 20mm)....
January 31, 2016
Microstructure of Peripapillary Atrophy and Subsequent Visual Field Progression in Treated Primary Open-Angle Glaucoma
Author(s): Yamada H (1), Akagi T (2), Nakanishi H (1), Ikeda HO (1), Kimura Y (1), Suda K (1), Hasegawa T (1), Yoshikawa M (1), Iida Y (1),...
January 31, 2016
Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport
Author(s): Kleesattel D, Crish SD, Inman DM PURPOSE: Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally...
January 31, 2016
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Patients with neovascular glaucoma secondary to ocular ischaemia syndrome need pan-retinal photocoagulation and urgent referral to a physician
The science behind the tip The cause of neovascular glaucoma in two thirds of patients is either proliferative diabetic retinopathy or an ischaemic...
December 31, 2015
Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma
Author(s): Caprioli J (1), de Leon JM (2), Azarbod P (2), Chen A (2), Morales E (2), Nouri-Mahdavi K (2), Coleman A (2), Yu F (3), Afifi A (4) 1...
December 31, 2015
Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy
Author(s): Van Bergen NJ (1), Crowston JG (1), Craig JE (2), Burdon KP (2), Kearns LS (1), Sharma S (2), Hewitt AW (1), Mackey DA (3), Trounce IA...
December 31, 2015
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Avoid the upper nasal quadrant when inserting an aqueous drainage implant, as it can result in acquired Brown syndrome
The science behind the tip Aqueous drainage tubes are commonly used in the surgical treatment of refractory glaucoma. New onset persistent diplopia...
November 30, 2015
Visual impairment and vision-related quality of life in the Early Manifest Glaucoma Trial after 20 years of follow-up
Author(s): Peters D (1), Heijl A (1), Brenner L (2), Bengtsson B (1) 1 Department of Ophthalmology, Skåne University Hospital, Lund University,...
November 30, 2015
Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma
Author(s): Roubeix C (1,2,3), Godefroy D (4,5,6), Mias C (7), Sapienza A (8,9,10), Riancho L (11,12,13), Degardin J (14,15,16), Fradot V...
November 30, 2015
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Artifacts in the SD-OCT images in a patient with glaucoma or suspected glaucoma may lead to an erroneous conclusion
The science behind the tip Structural measurements of the optic disc and retinal nerve fibre layer (RNFL) have become an indispensable tool in the...
October 31, 2015
Association between Platelet Function and Disc Hemorrhage in Patients with Normal Tension Glaucoma: A prospective cross-sectional study
Author(s): Shim SH (1), Kim JM (2), Woo HY (3), Shin KU (1), Koh JW (4), Park KH (5) 1 Department of Ophthalmology, Kangbuk Samsung Hospital,...
October 31, 2015
Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation
Author(s): Cueva Vargas JL (1), Osswald IK (2), Unsain N (3), Aurousseau MR (2), Barker PA (3), Bowie D (2), Di Polo A (4) 1 Department of...
October 31, 2015
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The ISNT rule is of limited benefit in differentiating early glaucoma from normal
The science behind the tip The ISNT rule states that a healthy optic disc has a characteristic configuration of the neuro-retinal rim; which is...
September 30, 2015
Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up
Author(s): Newman-Casey PA (1), Blachley T (2), Lee PP (3), Heisler M (4), Farris KB (5), Stein JD (3) 1 Department of Ophthalmology and Visual...
September 30, 2015
In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS
Author(s): Takihara Y (1), Inatani M (2), Eto K (3), Inoue T (4), Kreymerman A (5), Miyake S (6), Ueno S (7), Nagaya M (7), Nakanishi A (7), Iwao K...
September 30, 2015
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Patients with advanced glaucoma who are to undergo trabeculectomy should be warned that there is a small risk of permanent visual loss as a consequence of the surgery
The science behind the tip Transient visual disturbance after trabeculectomy is common and it can take several months for the vision to recover....
July 31, 2015
Relationship Between Daytime Variability of Blood Pressure or Ocular Perfusion Pressure and Glaucomatous Visual Field Progression
Author(s): Lee J (1), Choi J (2), Jeong D (1), Kim S (1), Kook MS (3) 1 Department of Ophthalmology, College of Medicine, University of Ulsan, Asan...
July 31, 2015
Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat
Author(s): Bogner B (1), Boye SL (2), Min SH (2), Peterson JJ (2), Ruan Q (2), Zhang Z (1), Reitsamer HA (1), Hauswirth WW (2), Boye SE (2) 1...
July 31, 2015
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In clinical practice, anterior segment OCT cannot replace gonioscopy as a method of examining the filtration angle
The science behind the tip The diagnosis and management of all types of glaucoma is dependent on the accurate evaluation of the angle and its...
June 30, 2015
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In every patient with ocular hypertension, search for signs of pseudoexfoliation syndrome as these patients are at significant risk of converting to glaucoma
The science behind the tip Patients with ocular hypertension and pseudoexfoliaton syndrome are twice as likely to convert to glaucoma as those...
June 30, 2015