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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

    Learn more...
    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

    Learn more...
  • Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular contact and diagnosing angle closure.1 AS-OCT and...

    Learn more...
    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

    The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular...

    Learn more...
  • Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide....

    Learn more...
    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

    Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic...

    Learn more...
  • Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of...

    Learn more...
    Retinal Nerve Fiber Layer Optical Texture Analysis

    Retinal Nerve Fiber Layer Optical Texture Analysis

    PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate...

    Learn more...
  • A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals. This study provides novel insight into the genetic...

    Learn more...
    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

    PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals....

    Learn more...
  • Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...

    Learn more...
    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading...

    Learn more...
  • Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...

    Learn more...
    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

    The Science behind the Tip The identification of an individual´s genetic risk of a disease is...

    Learn more...
  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

    Learn more...
    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

    Learn more...
  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

    Learn more...
  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

    Learn more...
    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

    Learn more...
  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

    Learn more...
  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

    Learn more...
The relationship between multiple deprivation and severity of glaucoma at diagnosis

NGP Paper

The relationship between multiple deprivation and severity of glaucoma at diagnosis

BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

March 01, 2024

Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

Tip of the month

Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular contact and diagnosing angle closure.1 AS-OCT and...

February 12, 2024

Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

Experimental Paper of the Month

Effective Treatment of Optic Neuropathies by Intraocular Delivery of MSC-sEVs through Augmenting the G-CSF-Macrophage Pathway

Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide....

February 12, 2024

Retinal Nerve Fiber Layer Optical Texture Analysis

Clinical paper of the month

Retinal Nerve Fiber Layer Optical Texture Analysis

PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of...

February 12, 2024

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

Clinical paper of the month

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals. This study provides novel insight into the genetic...

January 15, 2024

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

Experimental Paper of the Month

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...

January 15, 2024

Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

Tip of the month

Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...

January 15, 2024

Selective Laser Trabeculoplasty can be considered lifesaving treatment for the cornea when severe ocular disease co-exists with glaucoma

Tip of the month

Selective Laser Trabeculoplasty can be considered lifesaving treatment for the cornea when severe ocular disease co-exists with glaucoma

The Science behind the Tip Elevated intraocular pressure (IOP) and glaucoma are not uncommon in cases of cicatricial conjunctivitis (CC) such as...

December 17, 2023

Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering

Experimental Paper of the Month

Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering

Significance The “in silico–in vitro–in vivo” funnel holds significant potential for identifying targets to control cellular processes in research...

December 17, 2023

Validating Trend-Based End Points for Neuroprotection Trials in Glaucoma

Clinical paper of the month

Validating Trend-Based End Points for Neuroprotection Trials in Glaucoma

PURPOSE: The purpose of this study was to evaluate the power of trend-based visual field (VF) progression end points against long-term development...

December 17, 2023

Risk Factors for Failure in Glaucoma Patients undergoing Microshunt Implantantion

NGP Paper

Risk Factors for Failure in Glaucoma Patients undergoing Microshunt Implantantion

PURPOSE: Evaluate risk factors for failure of Microshunt in glaucoma patients. DESIGN: Multicenter retrospective cohort study. METHODS:250 eyes...

December 17, 2023

How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head

Experimental Paper of the Month

How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head

​ 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2Ophthalmic Engineering & Innovation Laboratory, Singapore Eye...

November 15, 2023

European Glaucoma Society research priorities for glaucoma care

Clinical paper of the month

European Glaucoma Society research priorities for glaucoma care

Background/Aims: The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that...

November 15, 2023

Exfoliation (pseudoexfoliation) syndrome (XFS, with or without glaucoma) is associated with clinically significant non-vascular systemic diseases.

Tip of the month

Exfoliation (pseudoexfoliation) syndrome (XFS, with or without glaucoma) is associated with clinically significant non-vascular systemic diseases.

The Science behind the Tip Systemic vascular dysfunction in XFS patients and statistically significant associations of systemic diseases with XFS...

November 15, 2023

BIG DATA SIG

SIG Corner

BIG DATA SIG

SIG Corner Editor: Hana Abou Zeid Chair: Ananth Viswanathan Co-chair: Marta Pazos Mission To understand the genetic causes of glaucoma and the...

October 15, 2023

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Experimental Paper of the Month

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Author(s): Xikun Han 1,2,37 , Puya Gharahkhani 1,2,3,37, Andrew R. Hamel 4,5, Jue Sheng Ong 1, Miguel E. Rentería 2,3,6, Puja Mehta 4,5, Xianjun...

October 15, 2023

MERCURY‑3: a randomized comparison of netarsudil/latanoprost and bimatoprost/timolol in open‑angle glaucoma and ocular hypertension

Clinical paper of the month

MERCURY‑3: a randomized comparison of netarsudil/latanoprost and bimatoprost/timolol in open‑angle glaucoma and ocular hypertension

Author(s): Ingeborg Stalmans1,2 · Kin Sheng Lim3 · Francesco Oddone4 · Marek Fichtl5,6 · Jose I. Belda7,8 · Anton Hommer9 · Guna Laganovska10 ·...

October 15, 2023

Consider sources of bias when using OCT angiography

Tip of the month

Consider sources of bias when using OCT angiography

The Science behind the Tip OCT angiography (OCTA) has gained great interest in glaucoma diagnosis (1, 2) and follow up(3). However, several...

October 15, 2023

Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer

Experimental Paper of the Month

Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer

Author(s): Ronen E Mukamel (1), Robert E Handsaker (2), Maxwell A Sherman (3), Alison R Barton (4), Margaux L A Hujoel (5), Steven A McCarroll (6),...

September 15, 2023

Long-term Impact of Immediate Versus Delayed Treatment of Early Glaucoma: Results From the Early Manifest Glaucoma Trial

NGP Paper

Long-term Impact of Immediate Versus Delayed Treatment of Early Glaucoma: Results From the Early Manifest Glaucoma Trial

PURPOSE: To compare long-term visual outcomes in the 2 arms of the Early Manifest Glaucoma Trial (EMGT) and determine if delayed treatment was...

September 15, 2023

OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing

Tip of the month

OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing

The Science behind the Tip Thanks to its high reproducibility,1-3 OCT has become widely used for monitoring structural optic nerve changes in...

September 15, 2023

Intravitreal bevacizumab improves trabeculectomy survival at 12 months: the bevacizumab in trabeculectomy study-a randomised clinical trial

Clinical paper of the month

Intravitreal bevacizumab improves trabeculectomy survival at 12 months: the bevacizumab in trabeculectomy study-a randomised clinical trial

Author(s): John A Landers, Sean Mullany, Jamie E Craig 1 Ophthalmology, Flinders University of South Australia, Adelaide, South Australia,...

September 15, 2023

Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema

Tip of the month

Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema

The Science behind the Tip Patients undergoing anti-VEGF (vascular endothelial growth factor) therapy for age-related macular degeneration or...

August 31, 2023

Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

Tip of the month

Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

July 30, 2023

Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

Clinical paper of the month

Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

July 30, 2023