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TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage
Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...
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Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma
Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...
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Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma
The Science behind the Tip NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Evidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening
Author(s): Chris Bradley (1), Kaihua Hou (2), Patrick Herbert (2), Mathias Unberath (2), Michael V Boland (3), Pradeep Ramulu (4), Jithin Yohannan...
March 01, 2023
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Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway
Author(s): Yunsheng Qiao (1), Zhongmou Sun (2), Chen Tan (1), Junyi Lai (1), Xinghuai Sun (1,3,4), Junyi Chen (1,3,4) 1 Department of Ophthalmology...
February 28, 2023
Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): Baseline Results and Costs of a Cluster-Randomized Trial
Author(s): Lisa A Hark (1), Jason D Horowitz (2), Prakash Gorroochurn (3), Lisa Park (2), Qing Wang (2), Daniel F Diamond (2), Noga Harizman (2),...
February 28, 2023
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Transconjunctival suturing techniques to treat over-filtration following trabeculectomy
Hypotony is a recognised complication following filtration surgery such as trabeculectomy (1). Where this is due to over-filtration, intervention...
February 28, 2023
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Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance
Author(s): Emmi Kapiainen (1,2,3), Harri Elamaa (1,2,3), Ilkka Miinalainen (2,3), Valerio Izzi (1,2,4,5), Lauri Eklund (1,2,3) 1 Oulu Center for...
January 31, 2023
Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial: Six-Year Results of Primary Selective Laser Trabeculoplasty versus Eye Drops for the Treatment of Glaucoma and Ocular Hypertension
Author(s): Gus Gazzard (1), Evgenia Konstantakopoulou (2), David Garway-Heath (3), Mariam Adeleke (4), Victoria Vickerstaff (5), Gareth Ambler (6),...
January 31, 2023
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Be aware of obstructive sleep apnoea as a risk factor for the development or progression of glaucoma
Obstructive sleep apnoea (OSA) affects almost 1 billion people aged 30-69 years worldwide, of which 425 million have a moderate to severe OSA (1)....
January 31, 2023
Consider glaucoma drainage implant in patients with iridocorneal endothelial syndrome
Glaucoma occurs in up to 70% of patients with iridocorneal endothelial syndrome (ICE) (1). Given the high failure rate of medical treatment,...
December 30, 2022
Estimating the Length of the Preclinical Detectable Phase for Open-Angle Glaucoma
Author(s): Johan Aspberg (1,2), Anders Heijl (1,2), Boel Bengtsson (1) 1 Department of Clinical Sciences in Malmö, Ophthalmology, Lund University,...
December 29, 2022
Effect of trabeculectomy on the rate of progression of visual field damage
Author(s): Susanna Friederike Koenig (1,2), Giovanni Montesano (3,4), Clarissa Ern Hui Fang (5), David Paul Crabb (3), Hari Jayaram (5,4), Jonathan...
December 29, 2022
Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma
Author(s): Haojie Fu (1,2), Owen M Siggs (3,4), Lachlan Sw Knight (3), Sandra E Staffieri (5,6,7), Jonathan B Ruddle (7), Amy E Birsner (1), Edward...
December 29, 2022
Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients
Publishing date: November 2022 Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia...
December 19, 2022
Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma
Author(s): Owen M Siggs (1,2), Ayub Qassim (1), Xikun Han (3), Henry N Marshall (1), Sean Mullany (1), Weixiong He (3), Emmanuelle Souzeau (1),...
November 30, 2022
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Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues
Author(s): Alireza Karimi (1), Reza Razaghi (1), Seyed Mohammadali Rahmati (2), Christopher A Girkin (1), J Crawford Downs (1) 1 Department of...
November 30, 2022
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Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients
Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia and blepharospasm. The elevated...
November 30, 2022
Long-Term Alcohol Consumption and Risk of Exfoliation Glaucoma/Glaucoma Suspect among US Health Professionals
Author(s): Akiko Hanyuda (1), Bernard A Rosner (2), Janey L Wiggs (3), Kazuno Negishi (4), Louis R Pasquale (5), Jae H Kang (6) 1 Department of...
October 31, 2022
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METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma
Author(s): Yang Pan (1), Akiko Suga (1), Itaru Kimura (2), Chojiro Kimura (3), Yuriko Minegishi (1), Mao Nakayama (1), Kazutoshi Yoshitake (1),...
October 31, 2022
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Consider evaluation of corneal endothelial cell count in pseudoexfoliation patients undergoing surgery
Corneal endothelial cell loss may lead to corneal decompensation with loss of vision, which may necessitate future endothelial transplantation for...
October 31, 2022
Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change
Author(s): Fengbin Lin (1), Shida Chen (1), Yunhe Song (1), Fei Li (1), Wei Wang (1), Zhenni Zhao (2), Xinbo Gao (1), Peiyuan Wang (1), Ling Jin...
September 30, 2022
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Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes
Author(s): Liang Li (1), Fang Fang (2), Xue Feng (1), Pei Zhuang (1), Haoliang Huang (1), Pingting Liu (1), Liang Liu (1), Adam Z Xu (3), Lei S Qi...
September 30, 2022
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When glaucoma is not glaucoma
An increased excavation of the optic nerve head is usually associated to glaucoma, but other optic neuropathies may also display an increased...
September 30, 2022
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External Validation and Clinical Applicability of Two Optical Coherence Tomography-Based Risk Calculators for Detecting Glaucoma
Author(s): Néstor Ventura-Abreu (1), Marc Biarnés (2), Sofia Batlle-Ferrando (1), María Teresa Carrión-Donderis (1), Rafael Castro-Domínguez (1),...
September 30, 2022
Next Generation Partnership SIG
SIG Corner Editor: Hana Abouzeid Chair: Gauti Johannesson Co-chairs: Esther Hoffmann, Anthony Khawaja, Francesco Oddone The goal of this SIG is to...
July 31, 2022
Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial
Author(s): Nevin W El-Nimri (1), Sasan Moghimi (1), Rafaella C Penteado (1), Elham Ghahari (1), Diya Yang (2), Nicole Brye (1), James Proudfoot...
July 31, 2022
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Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Author(s): Feng Tian (1), Yuyan Cheng (2), Songlin Zhou (1), Qianbin Wang (1), Aboozar Monavarfeshani (3), Kun Gao (2), Weiqian Jiang (1), Riki...
July 30, 2022