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TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage
Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...
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Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma
Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...
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Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma
The Science behind the Tip NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Be aware of IOP elevation in children treated with systemic glucocorticoids
Children have a high risk of developing IOP elevation with topical steroid-treatment, but may also develop it after systemic treatment (1–3). The...
July 30, 2022
Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Author(s): Roger Chou (1), Shelley Selph (1,2), Ian Blazina (1), Christina Bougatsos (1), Rebecca Jungbauer (1), Rongwei Fu (1,3), Sara Grusing...
June 30, 2022
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Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure
Author(s): Cheng Yang (1), Qianni Wu (2), Junqing Liu (3), Jingshan Mo (1), Xiangling Li (1,4), Chengduan Yang (1,5), Ziqi Liu (1), Jingbo Yang...
June 30, 2022
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UGH syndrome should be considered in every pseudophakic patient, with active unilateral inflammation and elevated intraocular pressure
Uveitis-Glaucoma-Hyphaema (UGH) Syndrome is a rare syndrome characterized by iris transillumination defects, microhyphaemas and pigmentary...
June 30, 2022
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Intravenous hypertonic saline to reduce intraocular pressure: the effect of splitting the bolus
Author(s): Pia Inborr (1), Mika Harju (1), Tero T Kivelä (1) 1 Department of Ophthalmology, University of Helsinki and Helsinki University...
June 30, 2022
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Hypotony-related complications, not numerical hypotony, should alarm the clinician
Chronic hypotony, defined as a pressure of ≤5 mmHg for >3 months, may occur after glaucoma surgery (1,2). Despite being traditionally regarded...
May 31, 2022
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial
Author(s): Carlos Gustavo De Moraes (1), Simon W M John (1,2,3), Pete A Williams (4), Dana M Blumberg (1), George A Cioffi (1), Jeffrey M Liebmann...
May 31, 2022
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Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion
Author(s): Lili Xie (1,2), Ling-Ping Cen (1,2 3), Yiqing Li (1,2,4), Hui-Ya Gilbert (1,2), Oleksandr Strelko (1,2), Cynthia Berlinicke (5,6,7,8),...
May 31, 2022
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When choosing a glaucoma operation, be guided by the target intra-ocular pressure (IOP)
In recent years, we have seen a vast expansion of incisional surgical techniques for glaucoma with a wide range of long-term efficacy and safety...
April 30, 2022
Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?
Author(s): Nathan Ingold (1,2), Adrian I Campos (1,3), Xikun Han (1,3), Jue-Sheng Ong (1), Puya Gharahkhani (1), David A Mackey (4), Miguel E...
April 30, 2022
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Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?
Author(s): Nathan Ingold (1,2), Adrian I Campos (1,3), Xikun Han (1,3), Jue-Sheng Ong (1), Puya Gharahkhani (1), David A Mackey (4), Miguel E...
April 30, 2022
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Be aware of glaucoma therapy-related ocular surface disease when planning filtration surgery!
Glaucoma eye drops, especially when containing preservatives, are responsible for clinical or subclinical ocular surface alterations (1). Amongst...
March 31, 2022
Policy-Driven, Multimodal Deep Learning for Predicting Visual Fields from the Optic Disc and Optical Coherence Tomography Imaging
Author(s): Yuka Kihara (1), Giovanni Montesano (2), Andrew Chen (1), Nishani Amerasinghe (3), Chrysostomos Dimitriou (4), Aby Jacob (3), Almira...
March 31, 2022
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Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma
Author(s): Luis Alarcon-Martinez (1,2), Yukihiro Shiga (3,2), Deborah Villafranca-Baughman )3,2), Nicolas Belforte (3,2), Heberto Quintero (3,2),...
March 31, 2022
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Intraocular Pressure and Its Relation to Ocular Geometry: Results From the Gutenberg Health Study
Author(s): Esther M Hoffmann (1), Fidan Aghayeva (1), Felix M Wagner (1), Achim Fiess (1), Markus Nagler (2), Thomas Münzel (3,4), Philipp S Wild...
March 30, 2022
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When prescribing Latanoprost, don’t forget about potential cardiovascular side effects
Prostaglandin analogues are advised as first line treatment for chronic open angle glaucoma by the European Glaucoma Society Guidelines for their...
February 28, 2022
The Weiss ring, a major confounding factor for measurements of peripapillary retinal nerve fiber layer thickness
Author(s): Min-Woo Lee (1), Min-Su Kim (2), Hwa-Young Yu (1), Kee-Sup Park (1), Young-Hoon Lee (1), Jung-Yeul Kim (3) 1 Department of...
February 28, 2022
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GWAS identifies two common loci associated with pigment dispersion syndrome/pigmentary glaucoma and implicate myopia in its development
Author(s): Mark J Simcoe (1), Ameet Shah (2), Baojian Fan (3), Hélène Choquet (4), Nicole Weisschuh (5), Naushin H Waseem (6), Chen Jiang (4),...
February 28, 2022
Neuroprotection SIG
SIG Corner Editor: Hana Abouzeid Chair: Maria Francesca Cordeiro Co-chair: Miriam Kolko SIG neuroprotection keeps an eye on new initiatives within...
February 21, 2022
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Unilateral ocular hypertension: have a look at the corneal endothelium
Unilateral ocular hypertension or glaucoma is often associated with secondary causes that should be explored to ascertain the visual prognosis and...
January 31, 2022
Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer
Author(s): Christopher Kai Shun Leung (1,2,3,4), Alexander Ka Ngai Lam (5), Robert Neal Weinreb (6), David F Garway-Heath (7), Marco Yu (8), Philip...
January 31, 2022
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Phase 1b Randomized Controlled Study of Short Course Topical Recombinant Human Nerve Growth Factor (rhNGF) for Neuroenhancement in Glaucoma: Safety, Tolerability, and Efficacy Measure Outcomes
Author(s): Gala Beykin (1), Laurel Stell (1), Muhammad Sohail Halim (1), Mariana Nuñez (1), Lilia Popova (1), Bac T Nguyen (1), Sylvia L Groth (1),...
January 31, 2022
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Mind the depth – forward displacement of the lens-iris diaphragm and myopic shift after ophthalmic surgery is suggestive of aqueous misdirection
Aqueous misdirection is a serious condition with potentially higher prevalence than expected. Predominantly observed after ocular surgery,...
December 31, 2021
Attitudes towards polygenic risk testing in individuals with glaucoma
Author(s): Georgina L Hollitt (1), Owen M Siggs (2), Bronwyn Ridge (2), Miriam C Keane (2), David A Mackey (3), Stuart MacGregor (4), Alex W Hewitt...
December 31, 2021
Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies
Author(s): Benjamin R Thomson (1,2), Pan Liu (1,2), Tuncer Onay (1), Jing Du (1,2), Stuart W Tompson (3), Sol Misener (1,2), Raj R Purohit (1,2),...
December 31, 2021