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TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage
Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...
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Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma
Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...
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Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma
The Science behind the Tip NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Virtual Reality-Based and Conventional Visual Field Examination Comparison in Healthy and Glaucoma Patients
Author(s): Jan Stapelfeldt (1), Serife Seda Kucur (1), Nina Huber (1), René Höhn (2), Raphael Sznitman (1) 1 ARTORG Center for Biomedical...
December 30, 2021
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Exfoliation (pseudoexfoliation) syndrome (with or without glaucoma) is associated with clinically significant non-vascular systemic diseases
The association of systemic vascular dysfunction and vascular diseases with exfoliation syndrome have been extensively studied in the last decades....
December 01, 2021
Association Between Visual Field Damage and Gait Dysfunction in Patients With Glaucoma
Author(s): Jian-Yu E (1,2), Aleksandra Mihailovic (1), Catalina Garzon (1), Jennifer A Schrack (2,3), Tianjing Li (4), Sheila K West (1), Laura N...
November 30, 2021
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
Author(s): K Saidas Nair (# 1), Chitrangda Srivastava (# 2), Robert V Brown (# 2), Swanand Koli (3), Hélène Choquet (4), Hong Soon Kang (2),...
November 30, 2021
Unplanned Return to the Operating Room After Trabeculectomy
Author(s): Nur Cardakli (1), David S Friedman (2), Michael V Boland (3) 1 Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins...
November 30, 2021
Exfoliation SIG
The goal of this SIG is to increase ophthalmologists’ knowledge on XFS and XFG, and to support the optimal clinical care in XFG in Europe. 1....
November 01, 2021
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Consider trabeculectomy as initial treatment for newly diagnosed advanced primary open angle glaucoma (POAG)
IOP control is of uttermost importance in advanced glaucoma to prevent blindness. The EGS guidelines recommend IOP in the low teens, e.g. 10-12mmHg...
October 31, 2021
In vivo imaging of the Schlemm's Canal and the response to Selective laser trabeculoplasty
Author(s): Toshit Varshney (1), Kishan Azmira (1), Shikha Gupta (1), Karthikeyan Mahalingam (1), Abhishek Singh (1), Dewang Angmo (1), Viney Gupta...
October 31, 2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Author(s): 1 Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 2 Department of Neuroscience, Yale...
October 31, 2021
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Take a look at the deviation maps when assessing structural change in glaucoma
The structural analysis of the thickness of peripapillary retinal nerve fiber layer (pRNFL) and the inner layers of the posterior pole with optical...
September 30, 2021
Long-Term Outcomes of Selective Laser Trabeculoplasty for Open-Angle Glaucoma in the Caribbean
Author(s): Tony Realini (1), Hazel Shillingford-Ricketts (2), Darra Burt (3), Goundappa K Balasubramani (4) 1 West Virginia University Eye...
September 30, 2021
Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury
Author(s): Ling-Ping Cen (1), Tsz Kin Ng (1,2,3), Jia-Jian Liang (1), Ciyan Xu (1), Xi Zhuang (1), Yu-Fen Liu (1,2), Shao-Lang Chen (1), Yanxuan Xu...
September 30, 2021
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The glaucoma intensive treatment study: interim results from an ongoing longitudinal randomized clinical trial
Author(s): Boel Bengtsson (1), Christina Lindén (2), Anders Heijl (1), Sabina Andersson-Geimer (1), Johan Aspberg (1), Gauti Jóhannesson (2,3) 1...
September 30, 2021
Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...
September 01, 2021
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In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked
Angle recession (AR) is a common complication after a blunt ocular trauma, and it is related to a higher risk of developing late-onset glaucoma...
July 31, 2021
Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma
Author(s): Erin A Boese (1), Wallace L M Alward (2), John H Fingert (2) Department Ophthalmology and Visual Sciences, Carver College of Medicine,...
July 31, 2021
A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure
Author(s): Guorong Li (1), Astrid F Nottebaum (2), Mitchell Brigell (3), Iris D Navarro (1), Ute Ipe (2), Sarthak Mishra (2), Maria Gomez-Caraballo...
July 31, 2021
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Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial
Pearls Manager: Hari Jayaram Patients newly diagnosed with Primary Angle Closure Glaucoma without advanced damage or Primary Angle Closure with IOP...
July 30, 2021
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Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good
Charles Bonnet syndrome (CBS) describes the presence of complex visual hallucinations with retained insight in the unreal nature of the phenomenon...
June 30, 2021
Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study
Author(s): N Douglas Baker (1), Howard S Barnebey (2), Marlene R Moster (3), Michael C Stiles (4), Steven D Vold (5), Anup K Khatana (6), Brian E...
June 30, 2021
Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma
Author(s): Pinkal D Patel (1), Yen-Lin Chen (2), Ramesh B Kasetti (1), Prabhavathi Maddineni (1), William Mayhew (1), J Cameron Millar (1), Dorette...
June 30, 2021
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Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data
Author(s): Giovanni Montesano (1), Harry A Quigley (2), David P Crabb (3) 1 City, University of London Optometry and Visual Sciences (G.M.,...
June 30, 2021
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Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial
Pearls Manager: Hari Jayaram Newly diagnosed patients with Ocular Hypertension or Open Angle Glaucoma were randomised to one of two treatment...
June 30, 2021
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Consider focal pressure in case of poor filtration shortly after trabeculectomy
Achieving a good filtration in the early postoperative period after trabeculectomy is associated with the procedure's long-term success (1)....
May 31, 2021
Ten-Year Clinical Outcomes of Acute Primary Angle Closure Randomized to Receive Early Phacoemulsification Versus Laser Peripheral Iridotomy
Author(s): Poemen P Chan (1,2), Fang Y Tang (1), Dexter Y Leung (1,3), Thomas C Lam (1,2), Nafees Baig (1,4,3), Clement C Tham (1,2,5) 1 Department...
May 31, 2021